Mechanisms of Disease EnvironmentalNutritional Diseases of Infancy and Childhood June 17, 2003 - PowerPoint PPT Presentation

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Mechanisms of Disease EnvironmentalNutritional Diseases of Infancy and Childhood June 17, 2003

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Mechanisms of Disease. Environmental/Nutritional/ Diseases of ... UV irradiation. Physical Environment. Wounding = E x 1/T x 1/A x k. abrasion. laceration ... – PowerPoint PPT presentation

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Title: Mechanisms of Disease EnvironmentalNutritional Diseases of Infancy and Childhood June 17, 2003


1
Mechanisms of Disease Environmental/Nutritional/
Diseases of Infancy and Childhood June 17, 2003
  • Stephen L. Putthoff, D.O., FCAP
  • Chairman, Department of Pathology and Anatomy

2
Table 10-3, pg. 409 Table 10-4, pg. 409
3
Don't smoke and tell your patients not to.
Don't smoke, and tell your patients not to
4
How much do you drink?
  • Do you have an alcohol problem? It might be
    useful if you reflected upon it
  • Do you have any friends who you think have, or
    may have a predilection for alcohol abuse but
    they seem oblivious?

5
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6
Table and images, p. 411
7
p413
8
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10
Common OTC agents
  • Acetaminophen
  • Aspirin

11
Pollution
  • Outdoor
  • Indoor

12
Industrial exposures
  • Volatile organics
  • Halogenated hydrocarbons
  • Plastics, rubber and polymers
  • Metals
  • Table 20-12, pg. 421

Table 10-11, p 419
13
Effects of lead
  • Clinical manifestations?

14
Pesticides
  • DDT
  • Diazanon
  • Malathion
  • Nicotine
  • Arsenic
  • Paraquat
  • Warfarin
  • Strychnine

15
Natural Toxins Radiation Injury UV
irradiation Physical Environment Wounding E x
1/T x 1/A x k abrasion laceration contusion g
unshot wounds characteristics, range,
etc. entries exits
16
Physical Injury contd
Thermal injuries burns hyperthermia hypothermia
Electrical injuries Atmospheric pressure
injury
17
Food and Nutrition
  • Nutritional deficiencies
  • Protein-energy malnutrition

Kwashiorkor
Marasmus
Table 10-20, pg. 438
18
Protein Energy Malnutrition
19
Vitamin deficiencies
  • Fat soluble
  • Water soluble

Table 10-21, pg. 440
Deficiency states vs. toxicity
20
Vit. A vs. Vit. C vs Vit. D
  • A Fig. 10-23, pg. 442
  • Eye xerophthalmia, etc.
  • D Fig. 10-24, pg. 443
  • rickets, osteomalacia
  • C Fig. 10-30, pg. 451
  • scurvy

Others beriberi, chelitis, pellagra, macrocytic
anemia,acrodermatitis enteropathica,
21
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22
Diet
  • High protein/low carbohydrate
  • Low protein
  • High carbohydrate
  • Basic principle eat less, exercise more

23
Chemoprevention of cancer
  • ??????

24
Diseases of Infancy and Childhood
  • PKU
  • Galactosemia
  • Cystic fibrosis
  • SIDS
  • Neuroblastoma
  • Wilms tumor
  • Congenital malformations
  • Perinatal infections
  • RDS-newborn
  • Erythroblastosis
  • fetalis

25
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