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Alzheimers Disease Future Perspectives

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Age 65 with Probable Alzheimer's Disease. Age Group. Percent ... Alzheimer's Disease and Estrogen. No Estrogen. AD risk with postmenopausal. estrogen use ... – PowerPoint PPT presentation

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Title: Alzheimers Disease Future Perspectives


1
Alzheimers DiseaseFuture Perspectives
  • Richard J. Hodes, M.D.
  • Director
  • National Institute on Aging
  • NIA/NIH/DHHS

2
Estimated Percentage of People over Age 65 with
Probable Alzheimers Disease
Percent
Age Group
Source Evans D , et al. JAMA , Vol. 262, No.
18, 1989.
3
Older Population by Age 1910 to 2030
(In millions)
69.4
65-84
85
53.2
39.4
35.0
31.1
25.5
20.1
16.6
12.3
9.0
6.6
4.9
4.0
1910
1920
1930
1940
1950
1960
1970
1980
1990
2000
2010
2020
2030
Projected
4
Alzheimers Disease and Estrogen
AD risk with postmenopausal estrogen use
Less estrogen
1.0
0.8
0.6
More estrogen
46
Relative Risk
0.4
0.2
0
Estrogen
No Estrogen
5
Estrogen Replacement as Treatment for AD
  • Hysterectomized women with AD received estrogen
    or placebo for 15 months
  • Estrogen did not improve cognitive function or
    delay the progression of disease
  • Estrogen may still be effective earlier in the
    disease process

Mulnard, R., JAMA Vol. 283 No. 8, 2000.
6
(No Transcript)
7
AD Prevention Trials Estimation of Risks
  • WHI study - adverse effects of estrogen/progestin
    additional cases per 10,000 women per year
  • 8 breast cancer
  • 7 coronary heart disease
  • 8 stroke
  • 8 blood clots in the lungs or legs
  • Risk of AD in women with MCI
  • 1,200 new cases per 10,000 women per year
  • Risk of AD in women 65 with a first degree
    relative with AD
  • 500 new cases per 10,000 women per year

8
Funded AD Prevention and Selected Treatment
Trials
April 2002
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