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Title:

Combating COPD

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(Caveats: U.S. only, prevention of progression, COPD only) COPD Drug ... Conclusion: strength of association between COPD progression and various interventions ... – PowerPoint PPT presentation

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Title: Combating COPD


1
Combating COPD
  • Benefit And Cost Comparison Of Various
    Interventions

2
Chronic Obstructive Pulmonary Disease
  • Symptoms
  • airway obstruction
  • shortness of breath
  • cough
  • Risk Factors
  • cigarette smoking
  • environmental pollution

3
Interventions Compared
  • 1) More effective drug treatments
  • 2) More effective smoking cessation programs
  • 3) Pollution reduction
  • (Caveats U.S. only, prevention of progression,
    COPD only)

4
COPD Drug Treatments
  • Today beta agonists, steroids, anticholinergics
  • Future improved anticholinergics and steroids
  • Functional benefit 280-300ml improvement in FEV1
  • Effectiveness 100
  • Total cost in U.S. 4.3 billion annually
    (including hospitalizations)

5
Smoking Cessation Programs
  • Today nicotine replacement/psychotherapy
  • Future nicotine receptor partial agonists,
    cannabinoid receptor antagonists
  • Functional benefit stops further lung damage
  • Effectiveness 8-10 success
  • Total cost in U.S. 1 billion annually

6
Pollution Reduction
  • Today significantly improved air quality
  • Future focus on ozone and PM
  • Functional benefit stops further lung damage
  • Effectiveness ?
  • Total cost in U.S. 8.8-12.8 billion annually

7
Conclusion
  • Best use of resources in the U.S.
  • More effective smoking cessation programs
  • More effective drug treatments
  • Pollution reduction

8
Recommendation
  • COHORT STUDY
  • Exposure smoking history, AQI
  • Outcome lung function, GOLD metrics
  • Conclusion strength of association between COPD
    progression and various interventions
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