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Diana Hodgins European Technology for Business Ltd

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Title: Diana Hodgins European Technology for Business Ltd


1
Diana Hodgins European Technology for Business Ltd
  • Development of Intelligent Implants

Unither Nanomedical and Telemedical
Conference 26th February 2009
Tel 44 (0)1438 822822 Web www.etb.co.uk
Email dmh_at_etb.co.uk
2
Overview
  • ETB is microsystem design company,specialising in
    motion sensor systems and has recently launched
    the Pegasus stride analysis system.

ETB acted as project co-ordinator for Healthy
Aims which was successfully concluded in 2008.
3
Healthy Aims Project structure
  • 23M Euro
  • 25 partners across Europe
  • 4 ½ years
  • 10 EU countries
  • Clinical, academic, manufacturers
  • Skills covered micro, nano, bio and wireless

4
(No Transcript)
5
Project aims
  • To advance state of the art for medical implants
    diagnostic equipment
  • Develop new medical products from concept to
    clinical trial
  • Integrate new processes materials into new
    medical products.
  • Niche market applications where latest
    technologies are applicable have impact

6
Some specific project goals
  • PRODUCTS
  • Upper limb control for stroke patients
  • Clinically viable body motion sensor
  • Glaucoma sensor
  • Intra-ocular retina implant
  • Brain pressure sensor
  • TECHNOLOGIES
  • Wireless communications from in the body
  • Electrodes for specialised implants
  • Biocompatible materials for use with implants
  • Power sources for implants

7
Complete pilot clinical trials with glaucoma
sensor
  • Five healthy volunteers have been fitted with the
    contact lens
  • Induced pressure change was detected on all five
    patients

8
Retinal implant
Electrode array attached to the retina
9
Retinal implant system
  • Three volunteers now fitted with the retinal
    implant

10
Intra-cranial pressure sensor system
  • Results indicate good short term comparison with
    gold standard

11
Cochlear implant
New electrodes are being developed which fit into
the modiolus to reduce damage to residual hearing
12
Medical Implant Communication Service (MICS)
Reasonable signal propagation characteristics in
the human body Approved in United States, Europe,
Canada, Australia and Japan.
13
Zarlink MICS - System
14
MICS Applications
Deep brain stimulation
  • Stimulatory Devices
  • Pacemaker
  • Implantable Cardioverter/Defibrillator (ICD)
  • Neurostimulators and pain suppression devices
  • FES (Functional Electrical Stimulation)
  • Measurement/Control/Other Devices
  • Drug infusion and dispensing
  • Artificial heart and heart assist devices
  • Implanted sensors
  • Control of other artificial organs and implanted
    devices

Neuro stimulation
Defibrillator
Cardiac pacemaker
Sensor
Drug delivery/ Insulin pump
Bladder control devices
15
Complete Implant Module
Matching network
Encapsulated ZL70101
Crystal
Assembled with patch antenna
16
MICS Base Station
17
Camera pill example
18
Two channel FES upper limb stimulator
Implant electrodes
Final test in surgery for wrist extension and
hand opening
Body worn external controller
19
Two channel FES upper limb stimulator
  • Three patients now fitted with the STIMuGRIP?
    implant
  • All show an improved quality of life

20
Motion monitoring products from ETB
  • Pegasus G senses acceleration in x, y and z axes,
    plus temperature
  • Pegasus I senses acceleration and rotation in x,
    y and z axes, plus temperature
  • Compact and light, 54g
  • Simply connect to a USB port PC for charging and
    downloading data

21
Pegasus Stride Analysis system
Pegasus 3-axes MEMS based accelerometer placed in
ankle strap
GPS placed in armband
22
Stride system
Measures stride frequency, stride length and
speed
23
Knee joint angle monitoring
Sensor located into pocket
24
Knee angle measurements
Work being undertaken with The London Knee Clinic
25
Temporal limb phasing
downstairs
upstairs
level
level
Phase ( of total stride)
Patient after undergoing right knee surgery at
The London Knee Clinic
26
Medical conditions that affect a persons gait
Diabetes Stride frequency affects the contact
time and pressure-time impulse in type 2 diabetes
patients, which is related to plantar ulceration.
  Osteoarthritis Gait function is affected by
osteoarthritis in the knee and can be improved by
training. Fall Detection in Elderly Elderly
peoples stride rate tends to increase with age
and their stride length decrease, which results
in a higher risk of falling. 
27
Medical conditions that affect a person gait
(cont)
Knee injury The knee angle of the injured knee
will be less than for the uninjured
one. Parkinsons Disease The stride length and
stride frequency relationship exhibits
abnormalities in people with Parkinsons disease.
Hydrocephalus Gait abnormalities are an early
clinical symptom in normal pressure hydrocephalus
(NPH) and gait change is often used in the
decision of whether to perform shunt surgery.  
28
Differences in gait on and off a treadmill
Lower stride frequency on a treadmill
Longer stride length on a treadmill
29
Energy expenditure from the stride system
Energy expended (calories burnt) is proportional
to stride frequency, Hence calories burnt can be
calculated from stride frequency
30
Healthy Aims Exploitation next 3 years
1
2
3
31
The results
  • ETB is now marketing gait monitoring products for
    human applications
  • FTM is producing FES systems
  • Zarlink is selling the MICS system
  • Others are at the final stages of development

32
Acknowledgements
  • The financial support of the EU FP6 programme was
    greatly appreciated by the Healthy Aims
    consortium.
  • The financial support of the UK TSB Assistive
    living programme is greatly appreciated for the
    follow up Gait analysis work by ETB.

33
Thank you
  • For further details contact
  • Diana Hodgins
  • dmh_at_etb.co.uk
  • Tel 00 44 (0)1438 822822
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