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Hibernation,%20Aging%20and%20Longevity

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Hibernating Bears are Hot! Body temperature: 30 - 34 C. Reference: ... Hibernating bears do not experience osteoporosis. What About Humans? ... – PowerPoint PPT presentation

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Title: Hibernation,%20Aging%20and%20Longevity


1
Hibernation, Aging and Longevity
  • Natalia S. Gavrilova
  • Leonid A. Gavrilov
  • Center on Aging, NORC/University of Chicago,
  • 1155 East 60th Street, Chicago, IL 60637

2
Study of Turkish hamsters, Science, 1981
3
Hibernation and longevity
  • a) Longevity of all hamsters in the study.
  • b) Longevity of the poor, moderate and good
    hibernators in the study

4
Hibernation correlates with longevity
r0.522 plt0.001
5
Distribution of deaths in (a) control and (b)
experimental hamsters
  • Number of deaths against age at death at
    intervals of 60 days for
  • a) control hamsters (mean 812 days, median
    843 days)
  • b) experimental hamsters (mean 914 days, median
    884 days)

6
Hibernation and Longevity in Bats
7
Hibernation and Longevity in Bat Species
  • (a) Average longevity for bat species that do and
    do not hibernate.
  • Numbers indicate sample size in each category.
  • (b) Average change in longevity between
    phylogenically independent comparisons in which
    hibernation was acquired.

8
Predictors of longevity in bats based on ANCOVA
for species and bivariate analysis of contrasts
9
Hibernation is not continuous!
  • There are cycles of hibernation and short
    awakening
  • (every week in ground squirrels)

10
(No Transcript)
11
You don't need to hibernate in order to delay
aging
  • Hibernation signals (darkness) may be
    sufficient!

12
Study of Siberian Hamster
13
Day length and reproductive success in females of
Siberian hamsters
  • A) Reproductive success of long-day (LD),
    short-day (SD) and short-day pinealectomized
    (SD-PX) females expressed as the percentage of
    females mated at 9 mo of age that delivered live
    litters.
  • B) Mean SEM live litter size at birth and
    weaning.

14
Short-day exposure and delaying reproductive
senescence in females of Siberian hamster
  • Mean SEM number of primordial follicles per
    ovary in SD and LD females at 13 and 26 wk of
    age. Asterisk () denotes significant effect of
    photoperiodic treatment at both ages

15
Growth curves for hamsters subjected to LD and SD
exposure
  • Mean SEM body mass (grams) of LD, SD, and SD-PX
    females from weaning at Postnatal Day 18 to 40 wk
    of age.

16
Conclusion
  • ???????? ?????? ???????? ????????!

17
Study of Black Bears
18
Black bear active and hibernating
19
Hibernating Bears are Hot!
  • Body temperature 30 - 34 C Reference Carey
    HV, Andrews MT, Martin SL.  Mammalian
    hibernation cellular and molecular responses to
    depressed metabolism and low temperature. Physiol
    Rev. 2003 Oct83(4)1153-81. Review. PMID
    14506303

20
Hibernating bears do not experience osteoporosis
21
What About Humans?
22
For More Information and Updates Visit Our
Website
  • http//longevity-science.org

You are Welcome to Post Your Comments at our
Blog
http//longevity-science.blogspot.com/
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