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ANABOLIC STEROIDS

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Title: ANABOLIC STEROIDS


1
ANABOLIC STEROIDS
  • Lew Spirtos
  • YSU Chemistry 3790, November 30th, 2005

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seSyringePS185mjpg.jpg
2
HISTORY Natural Era
  • 1930s- dogs
  • 1940s- POWs
  • 1950s- athletes
  • 1964- turning point

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x_w.jpg
3
HISTORY Synthetic Era
  • 1960s
  • world class athletes
  • 1970
  • 15 college athletes ( )
  • 1980s
  • black market
  • 1990
  • controlled dangerous substances
  • FDA DEA
  • Current
  • Estimated 1 million steroid users ( )
  • 90 users male ( )
  • sports

http//www.anabolicsmall.com/roida3a.htm
http//www.pppdesign.net/otw/drugawareness/steroid
s.htm
http//www.pppdesign.net/otw/drugawareness/steroid
s.htm
4
What is an anabolic steroid?
  • Natural Bioactive Molecules
  • promote cell division/ growth
  • Testosterone
  • Estrogen
  • Cholesterol
  • http//en.wikipedia.org/wiki/Testosterone

http//en.wikipedia.org/wiki/Cholesterol
5
What is a synthetic anabolic?
  • Structural Definition
  • Not found in nature.
  • How they are prepared.
  • Semi-synthetic
  • Natural Source Materials
  • Synthetic Chemistry Derivation
  • Advantages
  • Cost
  • Highly variable structure

6
USES
  • Stimulation of
  • Sexual development
  • Growth
  • Puberty
  • Bone marrow
  • Appetite
  • Muscle Mass
  • Stamina

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ace203.jpg
7
Taking Anabolic steroids
  • Oral
  • Injection
  • Sanitation
  • Intramuscular injection
  • Avoidance
  • Nerves
  • Blood vessels
  • Sites
  • Deltoid in upper arm
  • Outer thigh
  • Buttocks

http//www.steroid.com/inject.php
8
SYNTHESIS
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ghorseherbs.jpg
  • http//www.project-aware.org/images/Image23.gif

9
Synthesis
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nalincid_files/image002.jpg
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endo_intracrine2.gif
10
BALCO LAB
  • Production/manufacture
  • Victor Conte
  • MLB Team Balco

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e623473x.jpg
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vnum10hlenlrieUTF-8start20saN
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11
Legal and Moral Issues
  • Is it cheating?
  • Is it legal?
  • Is it worth it?

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ery/montgomery.jpg
12
Detection Times
  • Nandrolone decanoate- 18 mos.
  • Depo-testosterone- 3 mos.
  • Parabolan- 5 weeks
  • Andriol- 1 week
  • Clenbuterol- 4 days

http//cache.boston.com/images/bostondirtdogs//Hea
dline_Archives/steroid.jpg
http//www.anabolex.com/?c130a1052
13
Detection Methods
  • Separate from blood plasma.
  • Preseparation
  • Gas Chromatography (GC) Liquid Chromatography
    (HPLC)
  • Idendify them
  • Mass Spectroscopy
  • Race between forensic scientists users
    regulators

14
Test Standards and Accuracy
  • Procedures
  • EMIT- workplace
  • RIA- government
  • Courier- Olympic athletes
  • False positives
  • Ibuprofen
  • Cold remedies
  • Antibiotics
  • True positives
  • Poppy seeds
  • Testosterone supplements

http//www.medschool.lsuhsc.edu/microbiology/DMIP/
EmitR.gif
15
Not So Fast
  • Tests used to detect counter measures (urine
    tampering)
  • Urine color
  • Urine temperature
  • Creatinine
  • pH
  • Specific gravity

http//www.cbc.ca/news/background/steroids/gfx/tit
lephoto.jpg
16
Side Effects
  • Skin conditions (presumptive test)
  • Liver
  • Male reproductive
  • Cardiovascular
  • Psychological

http//www.testosteronesteroids.com/images/steroid
s.jpg
17
ROID RAGE
  • Altered hormone levels
  • Inability to control behavior
  • Severe mood swings
  • Irritability
  • Violent aggression
  • Depression

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anowski_fp.jpg
http//www.calpoly.edu/rkiley/roidrage.jpg
18
ANDRIOL
  • Dosage- 8-16 40 mg caps daily
  • Street price- 1 for 40 mg
  • Liver bypass lymphatic absorption
  • Orally available testosterone
  • Half-life 3-5 hrs
  • Compatibility

http//www.bodybuilding.com/fun/catandriol.htm
http//www.bodybuilding.com/fun/catandriol.htm
http//www.steroidtips.com/andriol.jpg
19
DANATROL
  • Dose- 200-400 mg daily
  • 2-3 per 200 mg cap
  • Lack of popularity
  • Slightly androgenic
  • Expensive
  • Anti-aromatase prevents testosterone side
    effects
  • Bloating
  • Increased body fat
  • Gyno

http//www.bodybuilding.com/fun/catdanatrol.htm
http//www.bodybuilding.com/fun/catdanatrol.htm
20
Methyltestosterone
  • Dosage 25-50 mg/ day
  • Price 2 50 mg tablets for 1
  • First oral steroid
  • Works well bad side effects and high cost
  • Potent androgen
  • Prone to roid rage
  • High tendency to aromatize
  • Severe bloat and water retention

http//www.bodybuilding.com/fun/catmethyl.htm
http//www.bodybuilding.com/fun/catmethyl.htm
21
Orabolin
  • Dosage 20-50 mg/ day
  • Price 1-2 for 20 mg
  • Good androgen binding
  • Lack of 19th C
  • Reesterify easily
  • Good progesterone binding
  • Worsens estrogenic side effects

http//www.bodybuilding.com/fun/catorabolin.htm
http//www.bodybuilding.com/fun/catorabolin.htm
22
SUSTANON 250
  • Dosage 250-1000 mg/ week
  • Price 10-30/ ml
  • 4 esters increase exposure to adipose tissue
  • Stacks well with any compound
  • Extreme anabolic tendencies
  • Good and bad
  • Injectables

http//www.bodybuilding.com/fun/catsust.htm
http//www.bbc.co.uk/radio1/onelife/health/drugs/i
mages/steroids_hit.jpg
23
References
  • www.steroid.com
  • www.bodybuilding.com
  • www.steroidworld.com
  • www.wikipedia.com
  • www.wrestlingusa.com
  • www.anabolicsmall.com
  • www.steroids.com
  • www.pharmaeurope.com
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