Examples of Research Happening in the Department of Surgery

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Examples of Research Happening in the Department
of Surgery
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CADENCE Research Group Our Mission

• Founded and directed by Dr. Andre Lamy in 2000
• Our mission is as its name stated Cardiac
  Diseases Economic Analysis and Clinical
  Evaluation
• We have participated in many clinical trials,
  conducted and published economic analysis
  such as HOPE, CURE, MEDENOX, Canadian
  Off-pump CABG Registry.
• CORNARY trial (CABG Off or On Pump
  Revascularization Study), funded by the
  CHIR, is the the largest, multi-nation,
  randomized clinical trial in surgical patient
  populations.

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CADENCE Research Group Our People
From left to right Dr. Andre Lamy (Director)
Parvaz Khatib (Study coordinator), Helen Shing
(Research nurse), Sherry Wang (Health Economist),
Rosanne Kent (former manager), Patti Schneider
(Secretary), Lisa Trombetta (Database), Toni
Rizzo (Research nurse), Kamil Malikov (Project
Manager). Not in picture Cathy Ther (DataFax),
Kristina Novosel (Research Nurse).
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MacHANdMcMaster University Hand, Arm, Nerve

• What is MacHANd?
• MacHANd is a new initiative promoting excellence
  in education, clinical service, and research for
  hand and upper limb injuries, diseases, and
  disorders.
• Core Members
• Dr. J. Bain (Plastic Surgery) Dr. J. MacDermid
  (Rehabilitation Science)
• Dr. F. Farrokhyar (Surgery) Dr. J. Moro
  (Orthopaedic Surgery)
• Dr. N. Hynes (Plastic Surgery) Dr. K. Rajaratnam
  (Orthopaedic Surgery)
• Dr. C. Levis (Plastic Surgery) Dr. A. Thoma
  (Plastic Surgery)
• Current Projects
• The Impact of Waiting for Carpal Tunnel Surgery
• Health-Related Quality of Life (HRQoL) in
  Patients
• with Dupuytren's Disease A Prospective Cohort
  Study
• (NCT00468949)

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MacHANdMcMaster University Hand, Arm, Nerve

• Research Themes
• hand
• wrist
• elbow
• shoulder
• nerve
• occupational disorders
• articles/resources for EBP
• systematic reviews
• economic analyses
• utilities
• randomized controlled trials
• outcome measures

• For More Information
• Margaret Lomotan,
• Research Assistant
• E-mail lomotam_at_mcmaster.ca
• Phone [phone] Ext. 27328
• Website http//www.machand.ca

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Dr. Sheila Singhs Laboratory
Wednesday July 16, 2008

• Research Overview

• Dr. Singh is a pediatric neurosurgeon and
  scientist
• This is a basic science laboratory with a strong
  clinical focus
• The overall research goal is to further elucidate
  the cancer stem cell hypothesis in brain tumours
  and to characterize the Brain Tumour Initiating
  Cell (BTIC)
• Our work includes
  tissue culture work,
  molecular lab work
  and in vivo
  animal work

• Lab overview

• Operating since August 2007
• Located at the Stem Cell Cancer Research
  Institute at McMaster Main Campus
• Personnel includes one post doctoral fellow, one
  undergraduate student a research technician

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Cancer Stem Cell Hypothesis the BTIC

• Neural stem cells (found in brain) are tightly
  regulated differentiate into normal cells of
  brain tissue
• Cancer neural stem cells, by virtue of mutations,
  are dysregulated, self renew differentiate
  aberrantly, generating the abnormal cells that
  make up the brain cancer
• The BTIC was identified by its cell surface
  protein expression of CD133
• In 2004, Singh et. al identified an abnormal stem
  cell (termed the BTIC) that drove the formation
  of brain tumours (Nature, 2004432(7015)396-401)
• BTICs represent a small fraction of the whole
  tumour, but these cells alone may be entirely
  responsible for the continued growth of the
  tumour
• Clinical implications therapies that focus on
  killing the bulk of the tumour may miss the rare
  stem cell fraction, allowing the tumour to
  continue to grow potentially metastasize to
  form secondary tumours

Nature. 2004432(7015)281-2
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• Not recruiting residents for 2008-09 Core program
• Please contact us for more info
• Monika Lenkiewicz lenkiew_at_mcmaster.ca Sheila
  Singh ssingh_at_mcmaster.ca

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Dr. Peter J. Lovrics

• Clinical Associate Professor, McMaster University
• General Surgeon, specializing in breast oncology

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Dr. Lovrics - Research Projects

• A randomized, multisite, controlled trial of
  radioguided seed localization versus standard
  needle localization in early stage breast
  carcinomas funded by CBCF
• Practice patterns and perceptions of breast
  conserving surgery in early stage breast cancer
  Survey of Canadian General Surgeons and Radiation
  Oncologists funded by CBCRA
• A prospective cohort study to evaluate the impact
  of preoperative breast magnetic resonance imaging
  (MRI) on surgical decision-making in young
  patients with breast cancer funded by JCC
  Foundation

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Dr. Lovrics Research Projects

• Long term quality of life assessment of patients
  with early stage breast cancer using the Health
  Utilities Index
• Systematic review of radioguided breast surgery
  for nonpalpable lesions
• Technical and surgical factors affecting surgical
  margin status in breast conserving surgery (BCS)
• funded by JCC Foundation

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Dr. Marko Simunovic Associate Professor,
Department of Surgery Surgical Oncologist,
Juravinski Cancer Centre Research Coordinator
Angela Coates Email coatesa_at_mcmaster.ca
Research office 905-527-4322 x42472

• Clinical research area is colorectal cancer
  surgery
• Primary research focus - health services research
  
• Specific research interests
• Quality improvement - addressing quality gaps in
  surgery, CQI, surgeon-directed quality
  initiatives
• Knowledge translation

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Dr. Simunovic - Current projects

• Quality Initiative in Rectal Cancer (QIRC) Trial
• Protocol Simunovic et al. BMC Surg. 2008 Feb
  1584.
• Cluster randomized trial to test if a KT strategy
  can improve patient outcomes - permanent
  colostomy local recurrence
• 16 Ontario hospitals, 105 surgeons, 1015 patients
  
• Experimental arm surgeons received KT strategy
  - workshop, audit feedback, operative
  demonstrations, post-op questionnaires
• Patient data - diagnostic tests, surgery
  (procedure type, audit of OR note), pathology,
  pre post radiation/chemo
• Secondary analyses
• Pathology reporting radial margin distance
• Participation of experimental arm surgeons in the
  KT components
• Operative demonstrations surgeon satisfaction
  and perceived changes in surgical practice
• Project ideas Assess a quality marker, use of
  diagnostic tests, chemo/rads

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Dr. Simunovic - Current projects
Evaluating a knowledge translation strategy for
pancreatic surgery in Ontario (in progress)

• To determine if care was transferred to
  high-volume providers and if rates of operative
  mortality improved after release of
  recommendations (1999)
• Chart review data on 800 patients to assess
  surgeon, hospital and treatment measures
• Project idea Use chart review data to assess
  a process of care measure

• Other projects
• Assessing the uptake and effectiveness of
  laparoscopic surgery for colorectal cancer in
  Ontario - begins Fall 2008
• Improving the quality of colorectal and breast
  cancer surgery in LHIN 4 (Audit
  Feedback,Tailoring) colorectal is in progress
  breast to begin Fall 2008

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CLARITY Orthopaedic Research Group

• Dr. Mohit Bhandari MD, MSc, FRCSCCanadian
  Research Chair in Musculoskeletal Trauma
• Department of Surgery
• Department of Clinical Epidemiology and
  BiostatisticsMcMaster University

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Current Trials

• FLOW Fluid Lavage of Open Wounds A
  Multi-Center, Blinded, Factorial Trial Comparing
  Alternative Irrigating Solutions and Pressures in
  Patients with Open Fractures
• TRUST Trial to Evaluate Ultrasound in the
  Treatment of Tibial Fractures

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Current Trials

• FAITH Fixation using Alternative Implants for
  Treatment of Hip Fractures A Multi-Centre
  Randomized Trial Comparing Sliding Hip Screw and
  Cancellous Screws on Revision Surgery Rates and
  Quality of Life in the Treatment of Femoral Neck
  Fractures.
• HEALTH Hip Fracture Evaluation with Alternatives
  of Total Hip Arthroplasty versus
  Hemi-Arthroplasty A Multi-Centre Randomized
  Trial Comparing Total Hip Arthroplasty and
  Hemi-Arthroplasty on Revision Surgery and Quality
  of life in Patients with Displaced Femoral Neck
  Fractures

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• If you have any questions, some of the
• research assistants in the department
• are here today or
• feel free to contact them at any time.