The Penn CTSA and Institute for Translational Medicine and Therapeutics: Themes, obstacles, and oppo

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The Penn CTSA andInstitute for Translational
Medicine and TherapeuticsThemes, obstacles,
and opportunities
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Research at Penn ca 2000
BASIC TRANSLATIONAL CLINICAL
POPULATION OUTCOMES
Basic ScienceDepartments
CCEB
Basic ScienceCenters/Institutes
LDI
Disease-based Centers and Institutes
Clinical Departments
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Translational Research
Basic Research
Clinical Research
Proof of Concept and Mechanisms in Animals
Proof of Concept and Mechanisms in Humans
Larger randomized trials, observational and
outcomes studies
Translational Research
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Creation of the Institute for Translational
Medicine and Therapeutics (ITMAT) (Jan 2005)

BASIC TRANSLATIONAL CLINICAL
POPULATION OUTCOMES
ITMAT
Basic ScienceDepartments
CCEB
Basic ScienceCenters/Institutes
LDI
Disease-based Centers and Institutes
Clinical Departments
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ITMAT OBJECTIVES

• To integrate infrastructural and educational
  resources relevant to translational research
• To increase the number of investigators skilled
  in translational research
• To reduce the barriers to performing
  translational research
• To promote the creation and development of a new
  discipline translational medicine and
  therapeutics

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TRANSCENDANT THEMES OF THE PENN CTSA1.
Translational Therapeutics2. Bridging the
pediatric/adult divide3. Education and
investment in human capital
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TRANSCENDANT THEMES OF THE PENN CTSA1.
Translational Therapeutics
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Translational Therapeutics

• Overarching goal Promote and facilitate
  translation of preclinical studies into proof of
  concept and mechanistic studies in humans

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Translational Therapeutics

• Largest obstacle Bringing the multiple relevant
  operational components of translational research
  under one virtual roof in order to enable one
  stop shopping for the investigator and more
  substantially facilitate clinical and
  translational research

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Translational Therapeutics

• Formation of the Clinical and Translational
  Research Center (CTRC)

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Clinical and Translational Research
Center Co-Directors Carole Marcus and Dan Rader

• Clinical research inpatient and outpatient
  space
• Integrated CTRC Council
• Research nursing
• Clinical Core Services (CCS)
• Translational and Clinical Trial Organization
  (TACTO)
• Study Design and Biostatistics (SDAB)
• Kinetics, Modeling and Simulation (KMAS)
• Evoked Phenotype Initiative (EPI)
• Investigational Drug Service (IDS)
• Office of Human Subject Advocacy Protection
  (OHSAP)
• Junior Investigator Pilot Grant (JIPG) Program
• Translational Core Laboratories (TCL)

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TRANSLATIONAL CORE LABORATORIES
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Translational Therapeutics

• Clinical and Translational Research Center
• Integration of human genetics, clinical
  pharmacology, evoked phenotyping, and
  pharmacoepidemiology in the center for
  Personalized Medicine in Translation (PERMIT)

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Translational Therapeutics

• Clinical and Translational Research Center
• Personalized Medicine in Translation
• Integration of high-throughput screening,
  medicinal chemists, and strategic pharma
  collaboration in the center for Chemical Biology
  in Translation (CBIT)

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Translational Therapeutics

• Clinical and Translational Research Center
• Personalized Medicine in Translation
• Chemical Biology in Translation
• A systematic approach to application of
  bioinformatics to translational research in the
  center for Bioinformatics in Translation (BIIT)

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Translational Therapeutics

• Clinical and Translational Research Center
• Personalized Medicine in Translation
• Chemical Biology in Translation
• Bioinformatics in Translation
• Integration and promotion of novel imaging
  modalities in Translational Biomedical Imaging
  Center (TBIC)

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ITMAT/CTSA Centers
Translational BiomedicalImaging Center (TBIT)
Clinical and Translational Research
Center (CTRC)
Personalized Medicine in Translation (PERMIT)
Biomedical Informatics In Translation (BIIT)
Chemical Biology In Translation (CBIT)
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TRANSCENDANT THEMES OF THE PENN CTSA1.
Translational Therapeutics2. Bridging the
pediatric/adult divide
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Bridging the pediatric/adult divide

• Overarching goals Remove artificial barriers
  and promote collaborative clinical and
  translational research across the continuum of
  prenatal medicine through geriatrics create a
  new field of maturational genomics.

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Bridging the pediatric/adult divide

• Largest obstacle Bringing together a pediatric
  hospital and an adult health system that are
  corporately distinct with the goal of promoting
  clinical and translational research

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Bridging the pediatric/adult divide

• Integration of pre-existing pediatric and adult
  GCRCs in the Clinical and Translational Research
  Center (CTRC)
• Integration of the CTRC Council
• Integration of clinical and clinical research
  programs eg. autism, congenital heart disease,
  etc
• Integrated Clinical Cores and Translational Core
  Lab that serve pediatric and adult investigators
• Nascent initiative in maturational genomics
• Integration of informatics efforts
• Integration of training efforts

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TRANSCENDANT THEMES OF THE PENN CTSA1.
Translational Therapeutics2. Bridging the
pediatric/adult divide3. Education and
investment in human capital
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Education and investment in human capital

• Overarching goals Create new models for
  training clinical and translational researchers
  create and brand a new discipline of
  translational medicine and therapeutics.

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Education and investment in human capital

• Largest obstacle Amassing the substantial
  resources required for developing and expanding
  new training programs, supporting junior
  investigators, and creating and branding a new
  discipline

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Education and investment in human capital

• Get them young new programs for undergraduate
  students
• Favor them set aside medical school entrance
  slots
• Educate them flexibly MTR as a joint degree,
  free standing modules, flexible introductory
  experiences
• Support them adequately both salary and project
  support at critical career stages
• Provide a roadmap highlight and provide exposure
  to role models, ensure adequate mentoring and
  career guidance

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Education and investment in human capital

• Outreach to 6 local undergraduate colleges
• Expansion of existing MTR program
• Creation of MD-MTR with set aside slots in
  medical school admissions
• Creation of RN-MTR
• Creation of PhD-MTR
• New programs for educating basic scientists in
  translational research
• New programs for educating clinicians in clinical
  and translational research
• Joint strategies with FDA and industry

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Creating (and branding) a new discipline
Education and investment in human capital
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Creating (and branding) a new disciplineTransla
tional Medicine and Therapeutics?
Education and investment in human capital