Imaging Informatics at NCI

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• Imaging Informatics at NCI
• NCIA and caBIG Imaging Workspace

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Imaging InformaticsVision and Goals

• Support distribution of imaging data and
  associated metadata for
• Image review
• Annotations and mark-ups
• Quality assurance
• Overreads
• Data analysis
• Quality assurance
• Software development
• Device, drug, and software regulation and
  development

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Imaging Informatics Product LineVision and Goals

• Support repurposing of data generated by and
  archived for clinical trials
• Imaging informatics software open and freely
  distributed to other sites
• Interactive display of image data by authorized
  users for various subsets of an image database

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• Link imaging infrastructure to other NCI
  enterprise wide research data management systems
• Include pertinent vocabularies available through
  the Enterprise Vocabulary Services and include
  Common Data Elements

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Imaging Informatics Product LineVision and Goals

• Support data-driven oncology medical
  decision-making in research and clinical care
  throughout the world
• Create in Vivo Medical Imaging Workspace which
  will foster and accelerate work in
  interoperability, and in creating, optimizing,
  and validating imaging data and imaging software
  tools

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NCIA

• Creation of National Cancer Imaging Archive, NCIA
• Software for archive open and freely
  distributable and available for downloads
  beginning in April 2006
• Capacity of archive is currently approximately 10
  Terabytes with tape backup
• Support for LIDC, RIDER, IDRC (Imaging Database
  Resource Initiative)

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JBoss
Retrieval
Data Transfer Object (DTO)
Java Server Faces (JSF)
HTTP FTP
Field Centers at Remote Clinical Sites
Cancer Centers
Processors Query, Result set, User Registration,
Lookup Manager, CSM, Export
Submission
Data Access Layer
Data Manager
Data Manager
MDB Image zipping
Tomcat
Academia
MIRC
NCI Object API caCORE SDK
CSM API
MIRC Storage Service
DICOMHTTP HTTPS
Hibernate (I3 ORM)
Hibernate (CSM)
Hibernate (I3 ORM)
Firewall
MIRC DICOM Service
Industry
MIRC Database Service
NCIA DB (Annotations Image, Clinical, Markup,
etc.)
File System (DICOM, XML, DOC)
Researchers
Curation
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Proposed FY2015 Infrastructure Vision
FDA Gateway
Metadata Extensions and Interfaces
CTMS I/F (Clinical)
caBIG caTISSUE (Biospecimen)
NCIA I2 Image Archive Solution
Researchers (Industry, Academia, Cancer Centers)
NCICB caArray (Gene Expression)
Other (Proteomics, Histopathology, Animal, etc.)
caBIG Grid
PACS
NCIA Image Archive Solution
NCIA Image Archive Solution
Clinical Researchers
Clinical Research Cancer Centers
Clinical Care Facilities
Physicians
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NCI Imaging Informatics Image Repository Web
PageLibraries Available for Secure Download
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I2 Imaging Informatics Virtual Colonoscopy
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caBIG In Vivo Imaging Workspace

• Mission identify and improve the ways in which
  the wealth of information provided by such
  imaging, performed at academic and other research
  centers across the country, can be shared,
  optimized, and most effectively integrated into
  the ongoing effort to relieve suffering and death
  from cancer
• The In Vivo Imaging Workspace was launched during
  the first week of October 2005

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• Initial efforts will involve enlisting the widest
  possible representation from cancer centers,
  industry, organizations, and standards-setting
  groups
• Among the earliest of the cooperative workspace
  tasks has been the identification of overall aims
  and the most urgent challenges in cancer imaging
  and sharing of data
• The workspace will define the needs for and
  participate in creating, optimizing, and
  validating tools and methods to extract meaning
  from in vivo imaging data

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• In this process, participants will also be
  actively engaged in defining, refining, and
  evolving interoperable in vivo imaging
  informatics data standards
• The in vivo imaging technologies and modalities
  addressed will include systems for research and
  clinical imaging of live patients and animals
  (including single-cell organisms) used as model
  systems for human disease

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caBIG In Vivo Workspace

• 15 subject matter experts named in late summer
  2005
• First teleconference in Fall and then first face
  to face in mid December 2005
• 4 groups and leaders
• Software
• Vocabulary and lexicon
• Standards
• Grid/Architecture becoming Testbed

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caBIG In Vivo Workspace

• Highlights of 4 group recommendations available
  on LISTSERV and include
• Research workstation and software
• Vocabulary and Lexicon
• Standards such as IHE, small animal, clinical
  trials, teaching, grid enabled
• Testbed RHIO and CAD after meeting in Columbus
  Ohio with Joel Saltz et al

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Plans for 2006 and Beyond

• Visualization
• Additional libraries of images will be added
• Additional imaging services can be provided such
  as trial support and then remote viewing for many
  purposes
• Pathology and other non-radiology imaging?
• Would require major expansion and enhancements!

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Questions?