MUHC Research Institute Town Hall Meeting

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MUHC Research Institute Town Hall Meeting

• Goals for 2007 and beyond

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Town Hall Meeting

• Agenda
• Introduction - Challenges and Opportunities
• Vision and Hospital Strategic Research Plan
• Update on CFI Application to the Research
  Hospital Fund (RHF)
• Evolution of the Research Axes
• Update on the Glen Project
• Brief RI Financial Update
• Various Initiatives
• Open forum for comments and questions

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Biomedical Research Challenges and opportunities
in translational research
In search of the elusive trigger of integration
of brain power, data and application to healthcare
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Biomedical research challenges

• To define the challenges first we have to define
  the
• Determinants
• Participants
• Obstacles

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Biomedical research challenges

• Determinants of health
• Medical
• Social
• Behavioral
• Environmental
• Economic
• Education
• Employment
• Government
• Public Housing
• Culture
• Who is the most important healthcare provider in
  a retirement community?

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Biomedical research challenges

• Participants in todays healthcare
• Government (the creator)
• Clinics/Hospitals (the grand parent)
• Research Universities (the parent)
• Academic Medical Centers (the teenager)
• Pharmaceutical industry (the rich uncle)
• Biotech industry (in search of an identity in
  the family)

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Translational medicine obstacles

• Follow from hypothesis to application
• Omics, Ogics, Ostics the BABEL of science
• Animal models of disease and humans, the
  ultimate model organism
• Regulatory issues
• Bioethics
• Medical informatics
• Healthcare Delivery
• Outcomes and monitoring
• The role of the pharmaceutical industry (a
  researcher, a broker, or a salesman?)

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Translational medicine obstacles

• Participants in translational medicine
• 1. Administration
• 2. Clinicians
• 3. Scientists
• 4. Clinician/scientists
• 5. Public
• 6. Industry
• Who do they have to satisfy?
• 1. Government, politicians, public, oversight
  committees, economies, market, trends
• 2. Patients (one at the time), public,
  curiosity, trends
• 3. Patients (many per disease), public,
  curiosity, trends
• 4. Species under extinction
• 5. Its own healthcare within a political and
  economic framework
• 6. Investors, market, public

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The Change

• The biggest change to consider
• In 20th century lifestyle impacted health
• In the 21st century it is health that will
  impact lifestyle
• The ethical and socioeconomic impact of this
  change on the individual and the society has not
  been considered yet.

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Factors for success

• Biomedical organizations that cut across
  Universities, Medical Centers and
  Clinics/Hospitals
• Policies and funding to support capacity building
• Uniform and user-friendly processes
• Stable and flexible institutional environment
• Local leadership
• Merit based evaluation
• Effective local, national and international
  networking
• Metrics and benchmarks
• Effective internal and external communications
• Public support (fundraising, etc)
• Sustain a culture and capacity for discovery and
  innovation within the financial framework of the
  institution

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Overview of MUHC RI

• The McGill University Health Centre (MUHC) is the
  result of a merger in 1999 of five teaching
  hospitals affiliated with the Faculty of Medicine
  at McGill University.
• 360 Principal Investigators (PI), is currently
  organized into
• 11 (to merge to 8) programs/axes in alignment
  with the clinical programs at the Glen and
  Mountain Campuses.

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Vision

• Create a transformative, world-class, research
  institute (RI) bridging the gap between
  biomedical research and clinical medicine.

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Vision

• Create a transformative, world-class, research
  institute (RI) bridging the gap between
  biomedical research and clinical medicine.
• Create an environment that catalyzes original
  research, speeds innovation, accelerates the
  translation of basic discoveries to public uses
  while providing the basis for novel public health
  policies

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Vision

• Create a transformative, world-class, research
  institute (RI) bridging the gap between
  biomedical research and clinical medicine.
• Create an environment that catalyzes original
  research, speeds innovation, accelerates the
  translation of basic discoveries to public uses
  while providing the basis for novel public health
  policies
• Capitalize on the opportunity to bring together
  pediatric and adult research programs and focus
  on improving the health of individual patients
  throughout their life cycle

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Vision

• Create a transformative, world-class, research
  institute (RI) bridging the gap between
  biomedical research and clinical medicine
• Create an environment that catalyzes original
  research, speeds innovation, accelerates the
  translation of basic discoveries to public uses
  while providing the basis for novel public health
  policies
• Capitalize on the opportunity to bring together
  pediatric and adult research programs and focus
  on improving the health of individual patients
  throughout their life cycle
• Set the stage for the transition to patient
  centric medicine the successful care and
  treatment of the individual patient across the
  lifespan

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Hospital Strategic Research Plan

• Begun because of the following
• Migration from 5 sites to two Glen Mountain
• The CFI Research Hospital Fund (RHF) required a
  Strategic Research Plan (SRP) Summary
• The RI has to focus on fewer, stronger areas
  which can be supported over the long term.
• Complimentarité with the CHUM research plan
  (mandated by Quebec).
• Must take into account existing strengths in
  other Quebec-based institutions and to work in
  larger teams.

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SRP Key Elements

• Builds on the RHF/ CFI proposal and adds the
  Mountain Campus research themes (as we evolve
  towards the two campus model)
• Emphasis on Clinical Investigations
• Review of the functions, responsibilities and
  support of the Axis and Axis Leaders
• Research Management Structure
• Creation of new academic positions
• Research Support, training and knowledge transfer
• Commercialization Strategy

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SRP Process

• CFI proposal formed the basis
• Meetings with the Axis (starting in late Fall
  2007 continuing through to June 2008)
• Plenary Sessions on the overall strategic goals
  December 07 and March 08
• Budgeting exercise to provide adequate
  resources for our dreams
• Roll out of the SRP Fall 2008

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Evolution of the Research Axes

• Current situation
• 11 axis distributed at 5 hospital sites
• RI Redevelopment Plan
• Fewer Axes three axes to be merged
• 8 Axes at two locations Glen and Mountain

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Redevelopment Research Axes
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Patients
PATIENT
Patients
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McGill University Health CentreResearch Institute

• Translational Research and Intervention Across
  the Lifespan
• Submission to
• CFI
• for
• Large-Scale Institutional Endeavours (LSIE) Fund

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MUHC
(Aug 28 2007) CFI 15649 page 23
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Patients
Conception
PATIENT
Aging
Patients
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MUHC Glen Campus Research Infrastructure
Pre-Concept Layout Preliminary
(Sep 11 2007) CFI 15649 page 25
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Highlights of the RI - Glen Project

• Centre for Innovative Medicine The hub of
  Investigator driven clinical research.
• Pod 1 Adult Subject Clinical evaluation rooms
• Pod 2 Infectious Disease Unit
• Pod 3 Pediatric subjects
• Specialized Human Phenotyping Suites. Clinical
  trials / informatics unit, Rapid biochemistry
  labs and Tissue Processing Suite
• Imaging Unit (CT)
• Experimental Surgical Suite (in Adult Pavilion)
• Centre for Translational Biology
• Research Neighborhoods for groupings of 15 PI
• PI Offices Meeting and Conference Rooms
• Core and Platform Facilities
• Animal Holding and Transgenic Facility

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Institutional Commitments

• RI and McGill are committing to 27 academic
  positions towards the new infrastructure
• The CIM will receive 40 of the recruits
• Clinician and evaluative researchers as this is
  our highest priority area in the next five years.
  
• Additional Operational Allocations of
• 2.0 M/year for equipment and laboratory support
• 1.5 M/year re-allocation of funds over five
  years for managerial support of the CIM and CTB
  platforms and vivarium.
• Capital Allocations
• The MUHC is committing 45.5 million to complete
  the CFI funding for the building infrastructure
• and to securing 4.5 million in-kind
  contributions from partners

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Update on the Glen Project

• The RI has submitted an updated Functional and
  Technical Program (FTP)
• The FTP provided information on the building
  size, labs, offices, and all support services.
• There is regular communication between the MUHC
  and the Quebec Government
• Our discussions are progressing well and focusing
  on optimizing all aspects of the project.
• The MUHC is progressing with planning of the
  redevelopment project, via the P-P-P program for
  Glen Campus (construction start planned for mid
  2009).
• Modernization improvements to the existing
  Mountain campus will proceed in parallel.

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Update for the Mountain Campus

• Over time, the research infrastructure Mountain
  Campus will be brought up to the same standards
  as the Glen Site.
• Over time, most of the new research facilities
  will be located in the Livingston Pavilion.
• This will promote greater interaction between
  researchers and more efficient use of the space.

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FRSQ Plan de développement

• Every 4 years
• The updated plan is required by Dec 1, 2007
• Work is underway and we will be contacting the
  Axes Leaders and PI for validation of the data.
• Important Point This is essentially a
  competition for baseline support for the RI from
  the FRSQ (further details next slide).

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RI Financial Update

• Each year, the RI-MUHC receives approximately
  100 million in research funding
• RI Operational Budget 12.5 million
• Financial Sources of Support
• FRSQ 40
• Clinical trials overhead
• Indirect
• Foundation support
• Breakdown of expenses ()
• RI administration
• Core infrastructure costs
• Animal Holding Facilities
• Other
• Academic Costs
• Recruitment Start-up packages
• Tenure track salary commitments

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Other Initiatives

• Administrative Review (completed)
• Overhead Evaluation (in progress)
• Space Evaluation

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• Acknowledgments

Hundreds of faculty and staff and
J. Genest, L. Lands, S. Wing, L. Pilote R.
Tamblyn, D. Buckeridge B. Ward, M. Behr J.
Trasler, S. Laporte J. Martin, Q. Hamid P. Brodt,
J. Rak, N. Jabado, M. Burnier J. Bergeron, B.
Robaire D. Eidelman, R. Rozen N. Fournier, M.
Shapiro L. Dery-Capes, Y. Elbaz R. Levin, D.
Therien
A. Porter N. Rinfret
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Open forum for comments and questions