AACRASCO

1

• AACR/ASCO
• Methods in Clinical Research
• July 22-28, 2006
• NCI Support For Training and Career Development
  in
• Cancer Research
• NCI Cancer Training Branch
• Lester S. Gorelic, Ph.D.
• Program Director, Clinical/Prevention Sciences
• gorelicl_at_mail.nih.gov

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6 Learning Objectives

• Where are the grants
• Who to contact for information
• What is available
• How to navigate through a complex array of
  funding opportunities
• What each source of support provides
• How to use the support to achieve your research
  career goals

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National Cancer Institute Cancer Training Branch
(CTB)
Acting Branch Chief Carl Oberholtzer
oberholtzerc_at_mail.nih.gov Program
Directors David Eckstein
eckstein_at_mail.nih.gov Lester Gorelic
gorelicl_at_mail.nih.gov Nancy Lohrey
lohreyn_at_mail.nih.gov Dorkina Myrick
myrickd_at_mail.nih.gov
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Branch Chief Sanya A. Springfield
springfs_at_mail.nih.gov Program Directors H.
Nelson Aguila aguilah_at_mail.nih.gov Belinda
Locke lockeb_at_mail.nih.gov Peter Ogunbiyi
ogunbiyp_at_mail.nih.gov
Contact information
301-496-7344 phone http//minorityopportunities.nc
i.nih.gov
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General Characteristics of Grant Portfolio

• Large (gt1000 active grants)
• Complex (gt15 funding mechanisms)
• Continuum of support
• Institutional (CTB) and individual awards (CTB
  and CMBB)
• Administrative supplements (CMBB)
• Partnerships (CMBB)

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General Characteristics of CTB Grant Portfolio

• Research Career tracks (CTB)
• Basic science
• Patient-oriented (POR)
• Cancer prevention, control, behavioral population
  sciences (CPCBPS)

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CTB Portfolio Contacts

• Patient-oriented research (POR)
• Gorelic, Myrick
• PCBPS
• Gorelic, Myrick
• Basic science research
• Gorelic, Lohrey, Myrick

(PCBPSPrevention, control, behavioral
population sciences)
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Relevant Funding Mechanisms

• Patient-oriented research
• T32, K12, K23, K22, K24, K99/R00
• Prevention, Control, Behavioral, Population
  Sciences
• T32, R25T, F32, K07, K22, K05, K99/R00
• Basic science research
• T32, F32, K08, K22, K99/R00

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Funding Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track
T32

K08
Basic
RPG
K22
F32
T32
K12
POR
K22
F32
K23
PCBPS
T32, R25T
R25T
K22
K07, F32
K07
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Funding Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track

K08
Basic
K12
POR
K23
R25T
PCBPS
K07
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Relevant Components of CTB Grant Portfolio

• Institutional Grants
• T32, K12, R25T
• Predocs and postdocs
• Candidates do not need publications to apply for
  a slot
• Candidates do not need statement of institutional
  commitment to research career.

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Institutional Programs

• Broad-based training to focused research training
  or career development experience
• Prepare a young investigator for submission of an
  application for an individual award
• Young Early in research career with limited
  prior research experience
• Individual applies for a slot in the program

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Provisions of Institutional Programs

• Years of support
• Predoc T32 ( 5yrs) R25T (5 yrs)
• PostdocT32 ( 3yrs) K12, R25T (5 yrs)
• Appointees must be US citizen or permanent
  resident
• Required minimum percent effort (T32, K12)
• Stipends (T32)/ salaries (K12, R25T)
• Research support (R25T (pre- and post-), K12)

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Special Aspects of NCI K12 Programs

• Develop a cadre of clinician/PhD basic science
  researchers who can work in a team research
  environment to design and implement
  hypothesis-based therapeutic cancer clinical
  trials
• Clinicians only or clinicians PhD basic science
  researchers (21 ratio)
• Participation of multiple oncology disciplines
• Core didactic/research requirements providing a
  translational research experience
• Salary for PI

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Special Aspects of NCI R25T Programs

• Interdisciplinary team-oriented research
• Curriculum-based
• Multiple mentors/appointee
• Core didactic/research requirements
• Support for curriculum development,
  implementation, evaluation
• Salary support for PI
• No required minimum effort commitment

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Relevant Components of NCI Grant Portfolio

• Individual awards
• Mentored
• F32, K07, K08, K23
• Independent
• K22, K05, K24
• Cross
• K99/R00

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Relevant Components of NCI Grant Portfolio

• Individual mentored awards
• F32 (postdoc) Publications, but no institutional
  commitment
• K99/R00 Late postdoc/fellowship
• Regular Ks (junior faculty) Publications and
  institutional commitment

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Provisions of Individual Mentored Awards

• Three (F32) or five year (K07, K08, K23)
  nonrenewable
• US citizen or permanent resident
• Doctoral degree (F32, K07, K08, K23)
• May be concurrent R03/R21 PI
• Under special circumstances, may also be
  concurrent R01 PI

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Provisions of Individual Mentored Awards, contd

• Required minimum percent effort commitment
  (full-time, F32 75 effort, K07, K08, K23)
• Salaries (K07, K08, K23) or legislated stipends
  (F32)
• Research support (K07, K08, K23)

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Provisions of The NCI Transition Career Award
(K22)

• Three year non-renewable portagrant providing
  protected time to do research
• US citizen or permanent resident
• Doctoral degree (Non-Federal PhD basic
  scientists not eligible)
• 2 yrs Postdoc experience or Jr faculty
• Required percent effort commitment
• Apply for RPG within first 2 years
• Salary and research support

1st independent position for LE 2 years
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NIH Pathway to Independence (K99/R00) Award

• Two Phase Mentored/unmentored (independent)
• Mentored ( 2yrs)
• Intramural or extramural
• Up to 75K salary, 30K research support1, fringes
  and 8FA1
• Unmentored ( 3 yrs)
• Up to 249K/yr including salary, research
  support, fringes, full FA
• NCI restricts to human cancer

1 Not applicable to intramural appointments
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track

Basic
T32
K12
POR
K22
F32
K23
PCBPS
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track
Basic

T32
POR
F32
PCBPS
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track

Basic
POR
PCBPS
T32, R25T
R25T
K22
K07, F32
K07
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track

Basic
K12
POR
K22
K23
PCBPS
T32, R25T
K22
F32
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track

Basic
POR
PCBPS
T32, R25T
F32
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track
T32

RPG
K08
K22
Basic
F32
POR
PCBPS
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track
T32

RPG
Basic
F32
POR
PCBPS
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track
T32

Basic
F32
K12
POR
K22
K23
PCBPS
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track
T32

Basic
F32
POR
PCBPS
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track
T32

Basic
F32
POR
PCBPS
R25T
K22
K07
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Continuum of Opportunities
Independent
Mentored
Post Jr.Faculty
Junior Estabd
Track
T32

Basic
F32
POR
PCBPS
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Cancer Training Branch Website
cancer.gov/researchandfunding/ training
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Portfolio Responsibilities

• Supplement program
• H. Nelson Aguila
• Career(K) -awards
• Belinda Locke
• Partnerships
• Peter Ogunbiyi

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Opportunities for Enhancing Diversity in Cancer
Research
Predoc
Postdoc
Mentored Faculty
New Independent
Supplements To
RPGs
T32

R25T
Individual Awards
F31
F31
Mentored Ks
K01, K08, K23
K22
K22