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Biological Membranes

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Biological Membranes. Fig 10-14. Lipids define space, provide barrier, act as label ... Lipid rafts. Tethering. Complex formation. Why is this level ... – PowerPoint PPT presentation

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Title: Biological Membranes


1
Biological Membranes
Lipids define space, provide barrier, act as label
Fig 10-14
2
What else is in biological membranes?
3
Membrane Proteins
Transmembrane/Integral or Peripheral
What functions would require each category of
membrane protein?
4
Cells are stable
And yet they do this?
How?
CBI 10.1
5
Fluid Mosaic Model (revised)
1. Length and saturation of fatty acid chains in
phospholipids
6
More model
2. Amount of Cholesterol (and cholesterol paradox)
3. Temperature
7
More model 2
If everything can move is everything randomly
distributed?
Lipid rafts Tethering Complex formation
Why is this level of organization important for
correct cellular function?
8
Questions?
9
Membranes define organelles.How?
10
Cell City
11
Coordinating the parts and the whole
Overcoming the barrier ? ways to cross
a membrane gated transport
transmembrane transport vesicular transport
  • ways to signal without crossing
  • receptors and conformational change

12
Case Study 1
What else?
13
Graves opthalmopathy
14
Pretibial dermopathy
15
Goiter
16
History
17
Cause?
Unknown
Players?
18
Why use this case study?
Compare what should happen with What actually
occurs
Focus on Extracellular signaling Intracellular
signaling Protein structure and function
19
This week in Cell Bio
Lab Getting a feeling for the organism Mating
vs budding yeast what can you tell? microscopy/
plating experimental design Class
Extracellular signaling and cellular receptors
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