Title: Biological Membranes
1Biological Membranes
Lipids define space, provide barrier, act as label
Fig 10-14
2What else is in biological membranes?
3Membrane Proteins
Transmembrane/Integral or Peripheral
What functions would require each category of
membrane protein?
4Cells are stable
And yet they do this?
How?
CBI 10.1
5Fluid Mosaic Model (revised)
1. Length and saturation of fatty acid chains in
phospholipids
6More model
2. Amount of Cholesterol (and cholesterol paradox)
3. Temperature
7More model 2
If everything can move is everything randomly
distributed?
Lipid rafts Tethering Complex formation
Why is this level of organization important for
correct cellular function?
8Questions?
9Membranes define organelles.How?
10Cell City
11Coordinating the parts and the whole
Overcoming the barrier ? ways to cross
a membrane gated transport
transmembrane transport vesicular transport
- ways to signal without crossing
- receptors and conformational change
12Case Study 1
What else?
13Graves opthalmopathy
14Pretibial dermopathy
15Goiter
16History
17Cause?
Unknown
Players?
18Why use this case study?
Compare what should happen with What actually
occurs
Focus on Extracellular signaling Intracellular
signaling Protein structure and function
19This week in Cell Bio
Lab Getting a feeling for the organism Mating
vs budding yeast what can you tell? microscopy/
plating experimental design Class
Extracellular signaling and cellular receptors