Johns Hopkins Biostatistics for Clinical and Translational Research Biostat CenTeR

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Johns Hopkins Biostatistics for Clinical and
Translational Research (Biostat CenTeR)
Service, Innovation, Education
BERD Meeting Bethesda, MD Nov 20-21, 2008

• Daniel E. Ford, M.D., M.P.H. Director, Institute
  for Clinical and Translational Research
• Vice Dean for Clinical Investigation
• Scott L. Zeger, PhD Director, Johns Hopkins
  Biostat CenTeR
• Vice Provost for Research
• Michael E. Griswold, PhD Co-Director, Johns
  Hopkins Biostatistics CenTeR
• Director, Johns Hopkins Biostatistics
  Center

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Johns Hopkins Institute for Clinical and
Translational Research
Daniel E. Ford, M.D., M.P.H., ICTR Director
Clinical Resources
Research participant Recruitment office
Advanced Degree-Granting Programs
Biostatistics
Johns Hopkins ICTR
Participant Community Involvement
Study Design
Biomedical Informatics
Regulatory Support
A collaborative group system with overarching
goals and responsibilities
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Hopkins Biostatistics Key Components

• The Johns Hopkins Department of Biostatistics
• 25 faculty, 40 PhD students
• The Johns Hopkins Biostatistics Center
• 4 PhD, 3 masters-level statisticians
• Two GCRC Centers for Data Management and
  Statistics
• 3 PhD statisticians, 3 data managers
• Oncology Biostatistics
• 6 PhD, 6 masters-level statisticians
• Center for Clinical Trials
• 32 faculty, support staff
• Biostatistics Working Groups
• 10-20 faculty and students each
• K12 Clinical Research Methods Training
• 5 faculty, 2 staff
• Welch Center for Prevention, Epidemiology and
  Clinical Research
• 25 faculty, 100 staff, and 50 trainees.

4.5 FTEs
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Organization Biostat CenTeRJH Biostatistics for
Clinical and Translational Research
The Biostat CenTeR is spread
throughout JHMI and is
comprised of multiple service clusters and an
administrative cluster. Faculty innovators
are connected to and work with one or more
service clusters. Working groups of faculty are
represented by faculty symbol colors.
Faculty innovators
Service cluster
Administrative cluster
SZ
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Biostatistics CenTeR Specific Aims

• SERVICE Institute a biostatistics service
  organization that supports Johns Hopkins
  biomedical scientists in clinical and
  translational research.
• INNOVATION Participate in Multidisciplinary
  Working Groups to advance targeted clinical and
  translational research methods
• EDUCATION Promote continual learning of research
  methodology

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SERVICE

• Collaboration
• Study Design
• Data Informatics
• Analytics
• Translation
• Teaching
• Biostats Clinics
• CRU (GCRC) functions
• Protocol Development
• Protocol Review

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INNOVATION Multidisciplinary Working Groups for
translational research methods
Genome Wide Association Studies
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EDUCATION Web Products for Dissemination

• Open Courseware
• eCollab A Reproducible Research web-based system
  for documentation and dissemination
• Each significant collaboration will be captured
  by the creation of a web-page that documents
• The scientific question
• Links to background scientific references
• The statistical questions
• Text describing the recommended solution
• Any data analysis results and interpretations
• Hyper-links from text to the data set
• Software used to implement sample size planning
  or data analyses

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Education Open Course Ware
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Education Capturing Collaborations
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Education Capturing Collaborations
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Whats worked

• Proactive Service Free Biostats Clinics
  where clinicians gather
• (the java hut)

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Whats worked

• CenTeR wiki
• Translational Biostatistics Forums
• Continuing Statistical Education

• Advancing Service

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Whats worked

• CenTeR wiki
• Translational Biostatistics Forums
• Continuing Statistical Education

• Advancing Service

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Whats worked

• CenTeR wiki
• Translational Biostatistics Forums
• Continuing Statistical Education

• Advancing Service

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What Keeps Me Up At Night
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What Keeps Me Up At Night

• Supply 4.5 FTEs
• Demand

?

• Tracking
• Effort
• Outcomes
• Administration
• Centralized vs. Decentralized
• Research Translation Career Paths

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Johns Hopkins Biostatistics for Clinical and
Translational Research (Biostat CenTeR)
Service, Innovation, Education
BERD Meeting Bethesda, MD Nov 20-21, 2008

• Daniel E. Ford, M.D., M.P.H. Director, Institute
  for Clinical and Translational Research
• Vice Dean for Clinical Investigation
• Scott L. Zeger, PhD Director, Johns Hopkins
  Biostat CenTeR
• Vice Provost for Research
• Michael E. Griswold, PhD Co-Director, Johns
  Hopkins Biostatistics CenTeR
• Director, Johns Hopkins Biostatistics
  Center

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Reproducible Research Project Based Learning
Education
Scientific Question
A Research Pipeline
Study Design
Presentation Code
Protocols
Analytic Code
Text
Collection Informatics
Figures
Analytic Results
Article
Analytic Data
Tables
Measured Data
NumericResults
Why do we usually only see this?
Processing Code