Invivo Use of Optical Coherence Tomography in the Head and Neck: Preliminary Evaluation of the Niris

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In-vivo Use of Optical Coherence Tomography in
the Head and Neck Preliminary Evaluation of the
Niris System in a Clinical Setting

• Allen Foulad, Pedram Ghasri, Majestic Tam, M.D.,
  Chao Li, Jorge Perez, Zhongping Chen, Ph.D.,
  William B. Armstrong, M.D., Brian J. Wong, M.D.,
  Ph.D.
• University of California, Irvine

SPIE Biomedical Optics Exhibition 2008- San Jose
Convention Center, San Jose, CA January 19, 2008
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Optical Coherence Tomography

• Non-invasive, high-resolution imaging modality
• Provides cross-sectional images of various tissue
  substructures
• Tissue penetration of 1-2 mm
• Rapidly increasing role in the diagnosis and
  management of various diseases
• Examples of common uses retinal, urologic, and
  mucosal diseases

1310 nm light source 1.6 mm penetration depth
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Optical Coherence Tomography

• Low-coherence interferometry
• Superluminescent diode (spatially coherent)
• Light source split to the sample and a reference
  mirror
• Reflected coherent light is combined at the
  interferomter and the interference patterns are
  computed to create a 2-D image.

Sample
Detector
SLD R
Reference
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Niris Imaging Module

• Commercial time-domain OCT system
• Portable, compact design
• User-friendly software
• Turn-key operation

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Objectives

• To evaluate the use of the Niris system in a
  clinical setting by imaging various regions of
  the head, neck, and upper airway.

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Materials/Methods

• Approximately 100 Subjects at UCI Medical Center
  Beckman Laser Institute Clinic
• mucosal side of the lip
• gingiva
• buccal mucosa
• floor of the mouth
• lateral, dorsal, and ventral tongue
• ear
• Intraoperative imaging
• larynx
• paranasal sinuses
• ear

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Niris System
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Niris System
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• Results

• Oral Cavity Substructures
• Epithelium
• Basement Membrane
• Lamina Propria
• Papillae
• Blood Vessels
• Ducts/Glands

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Buccal Mucosa
SSE
LP
BM
1310 nm light source 1.6 mm penetration depth
SSE
BM
LP
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Floor of Mouth
SSE
BM
LP
GD
SSE
BM
LP
GD
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Lower Lip Mucosa
SSE
LP
BM
SSE
BM
LP
GD
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Ventral Tongue
SSE
LP
BM
SSE
BM
LP
GD
GD
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Dorsal Tongue
SSE
BM
FP
LP
SSE
BM
LP
FP
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Lateral Tongue
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Gingiva
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Soft Palate
SSE
LP
BM
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Oral Cavity Compilation
buccal mucosa
lip mucosa
ventral tongue
floor of mouth
dorsal tongue
lateral tongue
gingiva
soft palate
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Larynx
True Vocal Cord
False Vocal Cord
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Nasal Septum
PCE
LP
BM
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Conclusions

• Hallmarks of Niris System
• Compact
• Plug Play
• Effective use in the clinic and OR for
  identification of superficial tissue structures
• Epithelium
• Basement membrane
• Lamina propria
• Glands, ducts, blood vessels
• Potential Uses in Medicine
• Real-time image guidance for surgical procedures
• Monitoring disease states