NS 521 Lipoprotein Metabolism

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NS 521- Lipoprotein Metabolism

• Composition of Different Classes of Lipoproteins
• Apoproteins
• Exogenous Pathway
• Chylomicron Processing
• LPL
• Endogenous Pathway
• VLDL Synthesis and Processing
• Conversion of VLDL to LDL
• LDL Uptake
• Reverse Cholesterol Transport Role of HDL
• LCAT
• CETP
• Lp(a)

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Composition and Relative Size of Lipoproteins
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Electron Microscopic Images of Negative Stained
Lipoproteins
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Isolation of Lipoproteins by Ultra-centrifugation
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VLDL Synthesis in Hepatocytes
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LDL Trapping and Retention in the Artery Wall
Initiates Development of Atherosclerotic Lesions
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Lp(a) is Likely Highly Atherogenic Due to
Structural Resemblance to Plasminogen
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