Central Dogma, Expanded! - PowerPoint PPT Presentation

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Central Dogma, Expanded!

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Central Dogma, Expanded! Sept. 16, 2004. Chapters 13, 14 ... Cartoon of Central Dogma. Eukaryotes. Chromosome uncoiling. DNA promoter identified and activated ... – PowerPoint PPT presentation

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Title: Central Dogma, Expanded!


1
Central Dogma, Expanded!
  • Sept. 16, 2004

Chapters 13, 14 15 for details
2
Central Dogma plus
System Effects
3
Cartoon of Central Dogma
4
Eukaryotes
  • Chromosome uncoiling
  • DNA promoter identified and activated
  • RNA polymerase introduced
  • RNA synthesis (primary transcript, hnRNA)
  • 5 Cap added
  • poly-A tail added
  • Splicing of introns, linking exons
  • Transport to cytoplasm
  • Initial ribosome binding mAUG
  • Completion of ribosome and second codon
  • Synthesis of polypeptide
  • Post translational modification/transport to
    functional form and place

5
Nuclear RNA Processing - origin
6
Nuclear RNA Transcription - end
7
RNA Transcript Processing
8
Intron Removal
Note different snRNAs connect different places
in splicing including across exons so exons
may be excised along with introns (exon choice)
MultiplesnRNPs
9
Translation to ER
10
Types of RNA in Eukaryote
11
Flies and Mice
Each Region has differentpatterns of gene
regulation!
12
Developmental Patterns in Plants
23-44
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