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NIH 101: What You Need to Know! Daniel Sklare, PhD


NIDCD Mission in Research on Human Communication; Brief Orientation to NIH ... (NCRAR); Portland VA Research Foundation; Program Director: Marjorie Leek, PhD ... – PowerPoint PPT presentation

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Title: NIH 101: What You Need to Know! Daniel Sklare, PhD

NIH 101 What You Need to Know! Daniel Sklare,
PhD Lana Shekim, PhD, NIDCD Peggy McCardle,
PhD, NICHD ASHA LfS 08 Conference
  • Introduction to NIH 101 (Sklare)
  • Recent Research Training/Career Development
    Initiatives K99/R00 LRP NIDCD Outreach to the
    Health Professions (Sklare)
  • NIDCD Mission in Research on Human Communication
    Brief Orientation to NIH Research Project Grant
    Programs (R03, R21, R01) the People Behind Them
    (Program, Review, Grants Management) (Shekim)
  • NICHD Mission in Research on Human Communication
    NIH Two-Tiered Review Operations Who are your
    reviewers and what transpires at study section?
    The Funding Decision How Does it Happen?
  • QAs

Introduction to NIH 101
Environment of the Research Scientist Competing
for NIH Funding
The Facts of Life for Academic Researchers
  • Increasingly keen competition for grant support
  • Resources constant or diminishing NIH FY08
    Budget (29.2 billion 1 over FY07 funding) will
    have net effect of decreasing our research
    purchasing power from FY07
  • Extramural research funding is an increasingly
    important litmus test for academic recruitment,
    promotion tenure
  • Grantwriting skills thorough understanding of
    the review funding process essential for an
    academic research career
  • Like Navy pilots, best prepared applicants will
    compete successfully, even in the toughest times

A Darwinian Approach to Casting an Academic
Research Career
  • Survival of the fittest for research
  • Situate the individual in a supportive
    environment with just enough pressures for

Your Keys to Success
  • Your research idea/proposal
  • Your ability to stay focused on short-term
    long-term research career goals
  • If at the training stage, your training
    mentorship plan
  • Your commitment to/passion with research
  • Your grant writing skills

Winning the Big Prize- Your First NIH Grant What
the instructions wont tell you, but the sages
  • Grants are won or lost on the first page-
  • Make your message significant memorable keep
    it focused, yet simple
  • Leave visual space throughout the application
  • On the first page, present a significant problem
    that you attack with a directional, main
    hypothesis, sub-hypotheses testing the main,
    supported by your novel observations
  • Introduce a conceptual model, followed with your
    more formal model, each grounded in evidence
    identify the component you now address

Winning the Big Prize- Your First NIH Grant What
the instructions wont tell you, but the sages
will (cont.)
  • Constitute a research team high on commitment,
    targeted expertise, (ideally) track record with
  • Alternative explanations for expected/possible
    findings are intriguing opportunities
  • Your program officer is your friend, but respect
    the tight-rope s/he walks
  • While locking-in focus on your research program,
    regularly rethink your scientific journey

What is the National Institutes of Health (NIH)?
  • The steward of biomedical and behavioral research
    for the Nation
  • Composed of 27 Institutes and Centers (24
    awarding components)
  • NIH Mission Promote support fundamental and
    clinical/applied research on the nature and
    behavior of living systems the application of
    that knowledge to extend healthy life reduce
    the burdens of illness disability.

Where is this research conducted?
  • Extramural Research
  • Conducted by nonFederal scientists in 2000
    academic nonacademic research institutions in
    the USA abroad
  • 90 of NIH funds are extramural
  • Intramural Research
  • Conducted mainly in NIH laboratories

NIH Extramural Staff
Grants Management
Find the Funding Agency/Component (i.e., NIH
Institute) Whose Scientific Mission Funding
Priorities Fit Your Proposal
  • Consult relevant program officer before crafting
    an application (missions funding priorities
    evolve over time)
  • Frame research plan to help funding agency
    achieve its mission
  • Know the right grant program or mechanism how
    your funding source uses it (e.g.,
    Institute-specific provisions)
  • Stay informed on Federal Funding Opportunities
    Announcements (FOAs) (PA, RFA, RFP) Notices

Recent Research Training/Career Development
NIH Research Training Career Development
Awards Goals Expectations
  • Identify support those candidates from a
    diverse pool with highest potential to advance
    Nations health
  • Support research training, not clinical training
    (except for med students in integrated MD/PhD
  • Facilitate the transition of such individuals
    from research training stage to independent
    investigator stage
  • Underlying expectation from this support, if
    fruitful, is a fundable full-scale research
    grant, typically, a New Investigator R01

NIH Research Training and Career Development
  • Ruth L. Kirschstein National Research Service
    Awards (NRSAs)
  • Individual Fellowships (F30, F31, F32, F33)
  • Traineeships on Institutional Training Grants
    (T32, T35)
  • Career Development (K-)Awards
  • Mentored Junior Clinician-Investigator Awards
    (K08, K23)
  • Early-Stage Career Transition Awards (K99/R00)
  • Junior-Midcareer Mentored Research Scientist
    Development Award (K01)

NIH Pathway to Independence Award (K99/R00)
  • Nurture highly promising investigators to secure
    tenured research position R01 grant earlier in
    their careers mentored postdoctoral phase (K99)
    independent investigator phase (R00) (aggregate
    of up to 5 yrs of support) both phases require
    75 effort
  • Typically for seasoned postdocs with up to 5
    years experience
  • K99 Phase (1-2 yrs) Provides a level of salary
    support comparable with other junior-level
    K-awards (NIDCD up to 105k/yr) plus an
    allowance for research costs (NIDCD 25k/yr)
  • R00 Phase (up to 3 yrs) Provides up to 249k
  • US citizens non-citizens, including postdoc
    fellows in Federal agencies (e.g., Intramural NIH
    research fellows) eligible to apply

NIH Pathways to Independence Award
(K99/R00) -cont-
  • Transition to the R00 phase contingent on
    securing an appropriate extramural tenure-track
    junior-level faculty (or equivalent) position
    NIH administrative review
  • Application Receipt Dates June 12, Oct 12, Feb
  • http//
  • http//
  • http//

Guidance for Crafting a Successful K99/R00
  • Justify need for further mentoring (particularly
    if staying in same department lab as current
    postdoc experience)
  • K99 Research Plan distinct/dissociable from
    mentors research program
  • Show productivity (first-authored research pubs)
    to date high promise as an independent
  • Requisite plan for evaluating/monitoring
    candidates progress toward independence

Guidance for Crafting a Successful K99/R00
Application (cont.)
  • Career Development Plan well laid-out, fits
    candidates career goals facilitates transition
    to independence
  • K99/R00 Research Plan adequately detailed for
    reviewers to fully evaluate, well-integrated,
    laying out a programmatic line of research

NIH Loan Repayment Program (LRP)
  • Goal
  • Provide an incentive for health professionals
    (broadly defined) to proactively integrate
    clinical research, pediatric research and other
    targeted research areas into their career

Two NIH-wide Extramural Loan Repayment Programs
  • Clinical Research LRP
  • Defined by the NIH as Patient-Oriented Research
  • Pediatric Research LRP
  • Research directly related to diseases, disorders,
    /or other conditions in children

NIH Loan Repayment Program (LRP)
  • Must be a US citizen or permanent resident
  • Doctoral degree holders engaged in clinical
    research or pediatric research for two years from
    the LRP award date for at least 50 effort
  • Qualifying research funding source nonprofit
    institution/agency (including a university) or
    governmental agency
  • Educational debt must equal at least 20 of
    institutional base salary
  • Provides up to 35k (plus associated Federal
    taxes) per year for up to two years (aggregate of
    up to 70k) renewable

Clinical/Pediatric New/Renewal LRP Applications
Reviewed Awarded NIH-wide
NIDCD vs. NIH-wide Success Rates for FY07 LRP
  • NIDCD Success Rate 74 (35/47 applications
    assigned to reviewed by NIDCD)
  • NIH-wide Success Rate 52 (1,292/2,504
  • Of the 35 NIDCD LRP awards
  • 40 are renewal awards
  • 27 PhDs (15 SLPs Audiols) 8 MDs MD/PhDs (4

LRP Application Submission Information Resources
  • On-line application process (
    Sept 1 - Dec 1
  • Check NIH GUIDE or LRP homepage in summer
  • NIH Office of Loan Repayment
  • LRP Help Line (866) 849-4047
  • Daniel A. Sklare, Ph.D.
  • NIDCD LRP Coordinator
  • Tel 301-496-1804
  • Email

Funding Rates of NIDCD R01 New Investigator
R01 Applications During FYs 02-06 by PI Specialty
Funding Rate MD/ ORLS MD/ Non ORLs MD/ PhDs PhD/ SLPs PhD/ Auds Non- Clinical PhDs
R01 Applics 26 (32/121) 29 (28/97) 35 (44/125) 26 (41/155) 21 (21/101) 31 (573/1844)
New PI Applics 27 (8/30) 50 (5/10) 30 (7/23) 30 (9/30) 20 (2/10) 37 (95/260)
NIDCD Initiatives for Facilitating Emergence of
Independent Clinician-Investigators
  • Now provides up to 80k per year for
    research-related costs (research development
    support) for new K08/K23 awards (NOT-DC-08-002
  • Partnering with leadership of Audiology to
    develop research vision/culture encouraging AuD
    students to pursue training in clinical
    translational auditory research
  • Ruth L. Kirschstein National Research Service
    Award Short-Term Institutional Research Training
    Grants (T35) (06/03/05) http//
  • Seeking to partner with professional societies to
    develop national mentoring networks

Short-Term Institutional Research Training Grants
(T35) for AuD Students
  • Developing Research Careers in the Hearing
    Sciences Dept of Hearing Speech Sciences, Bill
    Wilkerson Center, Vanderbilt University Program
    Director Linda Hood, PhD
  • Short-Term Research Training for AuD Students
    Boys Town National Research Hospital Program
    Director Walt Jesteadt, PhD
  • Predoctoral Summer Training Program in Auditory
    Research National Center for Rehabilitative
    Auditory Research (NCRAR) Portland VA Research
    Foundation Program Director Marjorie Leek, PhD
  • The Academy and Audiologists in Academia (AAA)
    Vol 4 Issue 2

NIDCD Initiatives for Facilitating Emergence of
Independent Clinician-Investigators
  • NIDCD Administrative Research Supplements to
    Promote Emergence of Independent
    Otolaryngologist-Investigators two-year
    administrative supplement awards to active NIDCD
    R01s and P50s for junior (asst prof) clinical
    faculty in otolaryngology
  • Awardee works within research scope of parent
  • Awardee submits follow-up K08/K23 or R03
    application in Yr 2
  • Up to 100K per year for 50 commitment of effort
  • Application Dates May 1 Nov 1, 08 (one-time
    issuance with two receipt dates)

Benchmarks for success High but reachable
R01 funding
NIDCD Extramural Research Training Program
Contact (Across NIDCD Scientific Program Areas)
  • Daniel A. Sklare, Ph.D.
  • Research Training Officer
  • Tel 301-496-1804
  • Email
  • NIH Research Training website
  • http//
  • NIH New Investigator website
  • http//