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NIH 101: What You Need to Know! Daniel Sklare, PhD

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NIDCD Mission in Research on Human Communication; Brief Orientation to NIH ... (NCRAR); Portland VA Research Foundation; Program Director: Marjorie Leek, PhD ... – PowerPoint PPT presentation

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Title: NIH 101: What You Need to Know! Daniel Sklare, PhD


1
NIH 101 What You Need to Know! Daniel Sklare,
PhD Lana Shekim, PhD, NIDCD Peggy McCardle,
PhD, NICHD ASHA LfS 08 Conference
2
Outline
  • Introduction to NIH 101 (Sklare)
  • Recent Research Training/Career Development
    Initiatives K99/R00 LRP NIDCD Outreach to the
    Health Professions (Sklare)
  • NIDCD Mission in Research on Human Communication
    Brief Orientation to NIH Research Project Grant
    Programs (R03, R21, R01) the People Behind Them
    (Program, Review, Grants Management) (Shekim)
  • NICHD Mission in Research on Human Communication
    NIH Two-Tiered Review Operations Who are your
    reviewers and what transpires at study section?
    The Funding Decision How Does it Happen?
    (McCardle)
  • QAs

3
Introduction to NIH 101
4
Environment of the Research Scientist Competing
for NIH Funding
5
The Facts of Life for Academic Researchers
  • Increasingly keen competition for grant support
  • Resources constant or diminishing NIH FY08
    Budget (29.2 billion 1 over FY07 funding) will
    have net effect of decreasing our research
    purchasing power from FY07
  • Extramural research funding is an increasingly
    important litmus test for academic recruitment,
    promotion tenure
  • Grantwriting skills thorough understanding of
    the review funding process essential for an
    academic research career
  • Like Navy pilots, best prepared applicants will
    compete successfully, even in the toughest times

6
A Darwinian Approach to Casting an Academic
Research Career
  • Survival of the fittest for research
  • Situate the individual in a supportive
    environment with just enough pressures for
    success.

7
Your Keys to Success
  • Your research idea/proposal
  • Your ability to stay focused on short-term
    long-term research career goals
  • If at the training stage, your training
    mentorship plan
  • Your commitment to/passion with research
    tenacity
  • Your grant writing skills

8
Winning the Big Prize- Your First NIH Grant What
the instructions wont tell you, but the sages
will
  • Grants are won or lost on the first page-
    ENGENDER ENTHUSIASM!
  • Make your message significant memorable keep
    it focused, yet simple
  • Leave visual space throughout the application
  • On the first page, present a significant problem
    that you attack with a directional, main
    hypothesis, sub-hypotheses testing the main,
    supported by your novel observations
  • Introduce a conceptual model, followed with your
    more formal model, each grounded in evidence
    identify the component you now address

9
Winning the Big Prize- Your First NIH Grant What
the instructions wont tell you, but the sages
will (cont.)
  • Constitute a research team high on commitment,
    targeted expertise, (ideally) track record with
    NIH
  • Alternative explanations for expected/possible
    findings are intriguing opportunities
  • Your program officer is your friend, but respect
    the tight-rope s/he walks
  • While locking-in focus on your research program,
    regularly rethink your scientific journey

10
What is the National Institutes of Health (NIH)?
  • The steward of biomedical and behavioral research
    for the Nation
  • Composed of 27 Institutes and Centers (24
    awarding components)
  • NIH Mission Promote support fundamental and
    clinical/applied research on the nature and
    behavior of living systems the application of
    that knowledge to extend healthy life reduce
    the burdens of illness disability.

11
Where is this research conducted?
  • Extramural Research
  • Conducted by nonFederal scientists in 2000
    academic nonacademic research institutions in
    the USA abroad
  • 90 of NIH funds are extramural
  • Intramural Research
  • Conducted mainly in NIH laboratories

12
NIH Extramural Staff
Program
Review
Grants Management
13
Find the Funding Agency/Component (i.e., NIH
Institute) Whose Scientific Mission Funding
Priorities Fit Your Proposal
  • Consult relevant program officer before crafting
    an application (missions funding priorities
    evolve over time)
  • Frame research plan to help funding agency
    achieve its mission
  • Know the right grant program or mechanism how
    your funding source uses it (e.g.,
    Institute-specific provisions)
  • Stay informed on Federal Funding Opportunities
    Announcements (FOAs) (PA, RFA, RFP) Notices
    (NIH GUIDE, grants.gov)

14
Recent Research Training/Career Development
Initiatives
15
NIH Research Training Career Development
Awards Goals Expectations
  • Identify support those candidates from a
    diverse pool with highest potential to advance
    Nations health
  • Support research training, not clinical training
    (except for med students in integrated MD/PhD
    dual-track)
  • Facilitate the transition of such individuals
    from research training stage to independent
    investigator stage
  • Underlying expectation from this support, if
    fruitful, is a fundable full-scale research
    grant, typically, a New Investigator R01

16
NIH Research Training and Career Development
Awards
  • Ruth L. Kirschstein National Research Service
    Awards (NRSAs)
  • Individual Fellowships (F30, F31, F32, F33)
  • Traineeships on Institutional Training Grants
    (T32, T35)
  • Career Development (K-)Awards
  • Mentored Junior Clinician-Investigator Awards
    (K08, K23)
  • Early-Stage Career Transition Awards (K99/R00)
  • Junior-Midcareer Mentored Research Scientist
    Development Award (K01)

17
NIH Pathway to Independence Award (K99/R00)
  • Nurture highly promising investigators to secure
    tenured research position R01 grant earlier in
    their careers mentored postdoctoral phase (K99)
    independent investigator phase (R00) (aggregate
    of up to 5 yrs of support) both phases require
    75 effort
  • Typically for seasoned postdocs with up to 5
    years experience
  • K99 Phase (1-2 yrs) Provides a level of salary
    support comparable with other junior-level
    K-awards (NIDCD up to 105k/yr) plus an
    allowance for research costs (NIDCD 25k/yr)
  • R00 Phase (up to 3 yrs) Provides up to 249k
    TC/yr
  • US citizens non-citizens, including postdoc
    fellows in Federal agencies (e.g., Intramural NIH
    research fellows) eligible to apply

18
NIH Pathways to Independence Award
(K99/R00) -cont-
  • Transition to the R00 phase contingent on
    securing an appropriate extramural tenure-track
    junior-level faculty (or equivalent) position
    NIH administrative review
  • Application Receipt Dates June 12, Oct 12, Feb
    12
  • http//grants.nih.gov/grants/guide/pa-files/PA-07
    -297.html
  • http//grants.nih.gov/grants/guide/contacts/pa-07
    -297_contacts.htm
  • http//grants1.nih.gov/grants/new_investigators/Q
    sandAs.htm

19
Guidance for Crafting a Successful K99/R00
Application
  • Justify need for further mentoring (particularly
    if staying in same department lab as current
    postdoc experience)
  • K99 Research Plan distinct/dissociable from
    mentors research program
  • Show productivity (first-authored research pubs)
    to date high promise as an independent
    investigator
  • Requisite plan for evaluating/monitoring
    candidates progress toward independence

20
Guidance for Crafting a Successful K99/R00
Application (cont.)
  • Career Development Plan well laid-out, fits
    candidates career goals facilitates transition
    to independence
  • K99/R00 Research Plan adequately detailed for
    reviewers to fully evaluate, well-integrated,
    laying out a programmatic line of research

21
NIH Loan Repayment Program (LRP)
  • Goal
  • Provide an incentive for health professionals
    (broadly defined) to proactively integrate
    clinical research, pediatric research and other
    targeted research areas into their career
    trajectories

22
Two NIH-wide Extramural Loan Repayment Programs
(LRPs)
  • Clinical Research LRP
  • Defined by the NIH as Patient-Oriented Research
  • Pediatric Research LRP
  • Research directly related to diseases, disorders,
    /or other conditions in children

23
NIH Loan Repayment Program (LRP)
  • Must be a US citizen or permanent resident
  • Doctoral degree holders engaged in clinical
    research or pediatric research for two years from
    the LRP award date for at least 50 effort
  • Qualifying research funding source nonprofit
    institution/agency (including a university) or
    governmental agency
  • Educational debt must equal at least 20 of
    institutional base salary
  • Provides up to 35k (plus associated Federal
    taxes) per year for up to two years (aggregate of
    up to 70k) renewable

24
Clinical/Pediatric New/Renewal LRP Applications
Reviewed Awarded NIH-wide
25
NIDCD vs. NIH-wide Success Rates for FY07 LRP
Applications
  • NIDCD Success Rate 74 (35/47 applications
    assigned to reviewed by NIDCD)
  • NIH-wide Success Rate 52 (1,292/2,504
    applications)
  • Of the 35 NIDCD LRP awards
  • 40 are renewal awards
  • 27 PhDs (15 SLPs Audiols) 8 MDs MD/PhDs (4
    ORLs)

26
LRP Application Submission Information Resources
  • On-line application process (www.lrp.nih.gov)
    Sept 1 - Dec 1
  • Check NIH GUIDE or LRP homepage in summer
  • NIH Office of Loan Repayment www.lrp.nih.gov
  • LRP Help Line (866) 849-4047
  • Daniel A. Sklare, Ph.D.
  • NIDCD LRP Coordinator
  • Tel 301-496-1804
  • Email sklared_at_nidcd.nih.gov

27
Funding Rates of NIDCD R01 New Investigator
R01 Applications During FYs 02-06 by PI Specialty
Funding Rate MD/ ORLS MD/ Non ORLs MD/ PhDs PhD/ SLPs PhD/ Auds Non- Clinical PhDs
R01 Applics 26 (32/121) 29 (28/97) 35 (44/125) 26 (41/155) 21 (21/101) 31 (573/1844)
New PI Applics 27 (8/30) 50 (5/10) 30 (7/23) 30 (9/30) 20 (2/10) 37 (95/260)
28
NIDCD Initiatives for Facilitating Emergence of
Independent Clinician-Investigators
  • Now provides up to 80k per year for
    research-related costs (research development
    support) for new K08/K23 awards (NOT-DC-08-002
    http//grants.nih.gov/grants/guide/notice-files/NO
    T-DC-08-002.html)
  • Partnering with leadership of Audiology to
    develop research vision/culture encouraging AuD
    students to pursue training in clinical
    translational auditory research
  • Ruth L. Kirschstein National Research Service
    Award Short-Term Institutional Research Training
    Grants (T35) (06/03/05) http//grants1.nih.gov/gra
    nts/guide/pa-files/PA-05-117.html
    http//grants.nih.gov/grants/guide/contacts/pa-05-
    117_contacts.htm
  • Seeking to partner with professional societies to
    develop national mentoring networks

29
Short-Term Institutional Research Training Grants
(T35) for AuD Students
  • Developing Research Careers in the Hearing
    Sciences Dept of Hearing Speech Sciences, Bill
    Wilkerson Center, Vanderbilt University Program
    Director Linda Hood, PhD
  • Short-Term Research Training for AuD Students
    Boys Town National Research Hospital Program
    Director Walt Jesteadt, PhD
  • Predoctoral Summer Training Program in Auditory
    Research National Center for Rehabilitative
    Auditory Research (NCRAR) Portland VA Research
    Foundation Program Director Marjorie Leek, PhD
  • The Academy and Audiologists in Academia (AAA)
    Vol 4 Issue 2

30
NIDCD Initiatives for Facilitating Emergence of
Independent Clinician-Investigators
  • NIDCD Administrative Research Supplements to
    Promote Emergence of Independent
    Otolaryngologist-Investigators two-year
    administrative supplement awards to active NIDCD
    R01s and P50s for junior (asst prof) clinical
    faculty in otolaryngology
  • Awardee works within research scope of parent
    grant
  • Awardee submits follow-up K08/K23 or R03
    application in Yr 2
  • Up to 100K per year for 50 commitment of effort
  • Application Dates May 1 Nov 1, 08 (one-time
    issuance with two receipt dates)

31
Benchmarks for success High but reachable
R01 funding
Applicant
32
NIDCD Extramural Research Training Program
Contact (Across NIDCD Scientific Program Areas)
  • Daniel A. Sklare, Ph.D.
  • Research Training Officer
  • Tel 301-496-1804
  • Email sklared_at_nidcd.nih.gov
  • NIH Research Training website
  • http//grants1.nih.gov/training/extramural.htm
  • NIH New Investigator website
  • http//grants2.nih.gov/grants/new_investigators/in
    dex.htm
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