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The secretory product of an acinus is drained sequentially by the following :

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A striated duct (a segment lined by cuboidal-to-columnar epithelial cells with ... Multispecific organ anionic transporter (MOAT), which exports bilirubin ... – PowerPoint PPT presentation

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Title: The secretory product of an acinus is drained sequentially by the following :


1
  • The secretory product of an acinus is drained
    sequentially by the following
  • An intercalated duct (lined by low
    squamous-to-cuboidal epithelium). The
    intercalated duct is longest in the parotid
    gland.
  • A striated duct (a segment lined by
    cuboidal-to-columnar epithelial cells with basal
    infoldings containing numerous mitochondria). The
    striated duct is well developed in the
    submandibular gland. The epithelium of the
    striated duct participates in ion and water
    transport and secretes kallikrein. Both
    intercalated and striated ducts are modestly
    developed in the sublingual gland.
  • The intercalated, striated, and excretory
    intralobular segments are observed within the
    lobule, embedded in the connective tissue septa.
    An excretory intra-lobular duct is initially
    lined by cuboidal-to-columnar epithelium it
    becomes pseudostratified columnar when it joins
    the interlobular duct.

2
Intralobular ducts join to form the interlobular
duct, which is located outside the lobule,
between adjacent lobules. An interlobular duct is
lined by pseudostratified columnar epithelium.
Interlobular ducts converge to form a lobar
duct. Lobar ducts (lined by stratified columnar
epithelium, one of the few sites in the body
lined by this type of epithelium) join the main
duct (lined by stratified squamous epithelium)
near the opening into the oral cavity.
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  • Bile has five major functions
  • The excretion of cholesterol, phospholipids, bile
    salts, conjugated bilirubin, and electrolytes.
  • Contributes to fat absorption in the intestinal
    lumen.
  • Transports IgA to the intestinal mucosa by the
    enterohepatic circulation.
  • The excretion of metabolic products of drugs and
    heavy metals processed in the hepatocyte.
  • Conjugated bile acids inhibit the growth of
    bacteria in the small intestine.

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  • The transport of bile and other organic
    substances from the hepatocyte to the lumen of
    the bile canaliculus is an adenosine triphosphate
    (ATP)-mediated process. Four ATP-dependent
    transporters, present in the canalicular plasma
    membrane, participate in transport mechanisms of
    the bile.
  • Multidrug resistance 1 transporter (MDR1), which
    mobilizes cholesterol across the plasma membrane.
  • Multidrug resistance 2 transporter (MDR2), which
    transports phospho-lipids.
  • Multispecific organ anionic transporter (MOAT),
    which exports bilirubin glucuronide and
    glutathione conjugates.
  • Biliary acid transporter (BAT), which transports
    bile salts.

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