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DNA repair Chapter 5 4th edition MBoC

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Xeroderma pigmentosum XP A-G...skin cancer, neurological abnormalities. NER. Ataxia telangiectasia AT. Leukemia, lymphoma cellular X&g ray sensitivity genome ... – PowerPoint PPT presentation

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Title: DNA repair Chapter 5 4th edition MBoC


1
DNA repair Chapter 5 4th edition MBoC
  • Cell Biology
  • R. D. Gietz

2
Inherited syndromes with defects in DNA repair.
  • MSH2, 3,6, MLH1, PMS2…colon cancer… mismatch
    repair defect
  • Xeroderma pigmentosum XP A-G…skin cancer,
    neurological abnormalities. NER
  • Ataxia telangiectasia AT. Leukemia, lymphoma
    cellular Xg ray sensitivity genome instability…
    ATM protein activated by DS breaks.
  • BRCA-2… ovarian and breast cancer…repair by
    homologous recombination
  • Werner syndrome… premature aging… accessory 3
    exonuclease DNA helicase
  • Bloom Syndrome… cancer, stunted growth, genomic
    instability… Accessory DNA helicase for
    replication.
  • Fanconi Anemia A-G.. Congential abnormalities,
    Leukemia, genomic instability… DNA interstrand
    crosslink repair
  • 46 BR patient Hypersensitivity to DNA damaging
    agents genome instability… DNA ligase I

3
Fig 5-46
Red arrows- spontaneous oxidative damage Blue
arrows- hydrolytic attack… Green arrows-
methylation site.
4
5-47
5
5-47b
6
5-48
7
5-49
8
5-49b
9
Types of DNA repair
  • Most of the problem is during replication
  • Mispairing
  • Cell has an effective system for the handling of
    this type of damage.
  • Mismatch repair.

10
5-23
11
Types of DNA repair
  • Base excision Repair
  • Repair endonuclease
  • Uracil glycosylase
  • Urea glycosylase
  • Etc…
  • This is very specific for types of damage.
  • Evolutionary derived

12
5-50
13
5-51
14
Types of DNA Repair
  • Nucleotide Excision Repair
  • For removal of bulky DNA adducts
  • That distort the DNA backbone
  • Non specific types of Damage

15
5-50b
16
5-52
17
5-52
18
5-53
19
Cell cycle checkpoints monitor DNA repair
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