Figure 1. Mechanism of migration of leucocytes from peripheral blood into inflamed tissues. - PowerPoint PPT Presentation

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Figure 1. Mechanism of migration of leucocytes from peripheral blood into inflamed tissues.

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Northern blot showing glomerular expression of MCP-1 mRNA correlated with monocyte infiltration ... Northern blot showing synthesis of IL-1 decoy receptor in ... – PowerPoint PPT presentation

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Title: Figure 1. Mechanism of migration of leucocytes from peripheral blood into inflamed tissues.


1
Figure 1. Mechanism of migration of leucocytes
from peripheral blood into inflamed tissues.
Rolling
Activation
Adhesion
CD11a/CD18
Transmigration
CD11b/CD18
Selectins
Chemokines
ICAM-1
Chemotaxins
MCP-1
C5a
chemokines
2
Figure 2. Northern blot showing glomerular
expression of MCP-1 mRNA correlated with monocyte
infiltration
3
Figure 3. Schematic diagram showing regulation of
the effects of IL-1b.
Biological effects of IL-1 are tightly regulated,
in part by its endogenous receptor antagonist
(IL-1ra), as well as by expression of IL-1 type
II receptor (IL-1RtII). IL-1RtII (68 kD) binds to
IL-1b with high affinity (lower affinity for
IL-1a and IL-1ra) without signal transduction.
The extracellular domain of IL-1RtII can also be
released as a soluble receptor selective for
IL-1b. Hence, IL-1RtII is also know as a decoy
receptor that may reduce the effect of IL-1b.
4
Figure 4. Northern blot showing synthesis of IL-1
decoy receptor in the glomeruli of IL-4 treated
rats
5
Figure 5. Effect of IL-4 on glomerular
macrophages (Mf)
6
Figure 6. Blocking TNF-a prevented crescentic
glomerulonephritis
50
40
30
Crescents ()
20
10
0
sTNFR
Control
7
Figure 7. Delayed treatment with rolipramreduces
urinary TNF-a
500
(pg/17h)
p 0.05
400
a
300
200
Urinary TNF-
100
0
vehicle
rolipram
8
Figure 8. Delayed treatment with rolipram
reduces glomerular crescents
9
Figure 9. Short term treatment (day 0-7) with
IL-4reduction of renal injury at day 28
plt0.01
plt0.01
100
4
75
3
Crescents ()
Tubular damage
50
score
2
25
1
0
0
Control
IL-4
IL-4
Control
10
Figure 10. IL-11 inactivated glomerular
macrophages
All Mf
Activated Mf
Plt0.05
NS
2.0
50
40
1.5
ED-3 Mf/gcs
30
ED-1 Mf/gs
1.0
20
0.5
10
0.0
0
Control
IL-11
Control
IL-11
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