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Software Tools for Visualization and Analysis of Human Brain Data for Language Mapping.

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Software Tools for Visualization and Analysis of Human ... Sciences, UCLA and Workhost.com, 4Washington Regional Primate Research Center. Medical Procedure ... – PowerPoint PPT presentation

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Title: Software Tools for Visualization and Analysis of Human Brain Data for Language Mapping.


1
Software Tools for Visualization and Analysis of
Human Brain Data for Language Mapping.
Andrew V. Poliakov, PhD1, Rex M. Jakobovits,
PhD3, Richard F. Martin, PhD1,4, David P. Corina,
PhD2, James F. Brinkley, MD, PhD1 1Structural
Informatics Group, Department of Biological
Structure, University of Washington, 2Department
of Psychology, University of Washington,
3Department of Radiological Sciences, UCLA and
Workhost.com, 4Washington Regional Primate
Research Center
2
Medical Procedure Neurosurgery for intractable
epilepsy Objective Remove epileptic foci
while sparing the patients language function as
much as possible Method Language mapping
using electrical stimulation
3
The Data
  • MR scans acquired prior to surgery
  • cortical anatomy, veins, arteries
  • functional MRI
  • Data acquired during surgery
  • electrical stimulation map
  • phonograms

4
  • Information System for Language Mapping
  • Goal
  • Integrate diverse kinds of language data
  • Approach
  • Neuroanatomy is the common framework
  • Reconstruct patient-specific 3D models of the
    brain
  • Map other data modalities onto neuroanatomical
    models

Cortex
Stimulation sites
5
Information System for Language Mapping
1. Alignment 2. Masking 3. Reconstructing 3D
models 4. Integrating Stimulation Sites
6
  • Functional MRI
  • Novel technique
  • 1990
  • Non-invasive
  • Detects active areas
  • Useful for studying language function of the
    brain
  • May complement or even substitute electrical
    stimulation
  • Problem
  • How to relate to electrical stimulation data

7
Highlights
Highlighted areas represent the activation sites
close to the surface
8
Cut-away View
Removing a segment helps visualizing and
exploring functional activation in deep
structures
9
Interactive Viewing
Using a low-resolution (cartoon) model to
interactively manipulate the object (zoom, rotate
etc.) and scroll though the image volume
10
Software Implementation Skandha4 Is a General
Purpose Graphics Server Features Lisp
scripting and prototyping C primitives
computations, etc. Implemented on SGI Irix
Linux
11
Current Work
  • Web interface for visualization and analysis
    tools
  • Integrating database and visualization tools

12
Java-based
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Forms-based
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21
  • Web-accessible Multimedia Database
  • Stores Patient data, Images, 3D models
  • Organizes in a relational DB
  • Accessible on the Web

22
  • Conclusions
  • Information System for Language Mapping
  • Integrates
  • Structural MRI
  • 3D models
  • Stimulation Sites
  • Functional MRI
  • Visualizes Integrated Data
  • Will be used to
  • Validate functional MRI
  • Study language function in the brain
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