Department%20of%20Biopharmaceutics%20and%20Pharmacodynamics%20Faculty%20of%20Pharmacy,%20Medical%20University%20of%20Gdansk%20Head:%20Prof.%20Roman%20Kaliszan,%20Ph.D.,%20D.Sc.%20Corresponding%20Member%20of%20the%20Polish%20Academy%20of%20Sciences%20Prof.%20Antoni%20Nasal,%20Ph.D.,%20Barbara%20Damasiewicz,%20Ph.D., - PowerPoint PPT Presentation

View by Category
About This Presentation
Title:

Department%20of%20Biopharmaceutics%20and%20Pharmacodynamics%20Faculty%20of%20Pharmacy,%20Medical%20University%20of%20Gdansk%20Head:%20Prof.%20Roman%20Kaliszan,%20Ph.D.,%20D.Sc.%20Corresponding%20Member%20of%20the%20Polish%20Academy%20of%20Sciences%20Prof.%20Antoni%20Nasal,%20Ph.D.,%20Barbara%20Damasiewicz,%20Ph.D.,

Description:

Department of Biopharmaceutics and Pharmacodynamics. Faculty of ... Walnut Creek, CA, USA. School of Materials Science, Toyohashi University of Technology, ... – PowerPoint PPT presentation

Number of Views:151
Avg rating:3.0/5.0

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: Department%20of%20Biopharmaceutics%20and%20Pharmacodynamics%20Faculty%20of%20Pharmacy,%20Medical%20University%20of%20Gdansk%20Head:%20Prof.%20Roman%20Kaliszan,%20Ph.D.,%20D.Sc.%20Corresponding%20Member%20of%20the%20Polish%20Academy%20of%20Sciences%20Prof.%20Antoni%20Nasal,%20Ph.D.,%20Barbara%20Damasiewicz,%20Ph.D.,


1
Department of Biopharmaceutics and
PharmacodynamicsFaculty of Pharmacy, Medical
University of GdanskHead Prof. Roman Kaliszan,
Ph.D., D.Sc.Corresponding Member of the Polish
Academy of SciencesProf. Antoni Nasal, Ph.D.,
Barbara Damasiewicz, Ph.D., Michal Markuszewski,
Ph.D., Aleksandra Radwanska, Ph.D., Danuta Siluk,
Ph.D., Tomasz Baczek, Ph.D., Teresa Frackowiak,
Ph.D., Anna Wojdelko, M.Sc., Michal Marszall,
M.Sc., Pawel Wiczling, M.Sc., Aleksandra
Dabrowska, Ing., Janina Kozlów
  • Address Gen. J. Hallera 107, 80-416 Gdansk
  • Tel. 48 58 3493260
  • Fax 48 58 3493262
  • e-mail roman.kaliszan_at_amg.gda.pl

2
COLLABORATORS
3
PUBLICATION RECORDS
Books 10 Review Articles 14 Original
Reports 160 Full Papers in Symposium
Proceedings 30 Patents 6 Symposium
Abstracts 210 Published book reviews,
popularization of science, etc. 50
S 480
S IFgt250 Total number of citations ? 3.000
4
(No Transcript)
5
MEMBERSHIP OF EDITORIAL (ADVISORY) BOARDS
  • - Solubility Data Series (1985 - 1992)
  • - Quantitative Structure-Activity Relationships
    (1988 - 1997)
  • Biomedical Chromatography (since 1998)
  • Journal of Chromatographic Science (since 2000)
  • - Journal of Separation Science (since 2001)
  • - Journal of Pharmaceutical and Biomedical
    Analysis (since 2001)
  •  - Acta Chromatographica (since 1995)
  • Acta Poloniae Pharmaceutica - Drug Research
    (since 1997)
  • - Annales Universitatis Mariae Curie-Sklodowska
  • Annales Academiae Medicae Gedanensis
  • Farmacja Polska
  • - Gazeta AMG
  • - Sluzba Zdrowia
  • - Wiadomosci Farmaceutyczne

About 400 reviews of manuscripts presented to
some 30 international journals
6
CHOICE OF STRUCTURE
Example S 20 N 8 X SN X 208 25
600 000 000 N - number of substitution
sites S - number of substituents CA describes
? 12 000 000 compounds
7
Numerical descriptors of solute structures
Chromatographic retention parameters
Computerized statistical data processing
QSRR
Identification of informative descriptors
Determination of molecular separation mechanism
Quantitative comparison of columns
Retention prediction
Determination of complex physicochemical
properties
Evaluation of relative biological activity
8
 
Drug Water/lipid partition (log P, log kw)
Degree of ionization (pKa)
Lipid
  WATER I   pH1   Drug molecules I   neutral I
ionized I
  WATER II   pH1I   Drug molecules II   neutral
II ionized II
Example Kanamycin pKa 7.2 Milk pHI
6.4 Blood pHII 7.4
             
9
IMMOBILIZED ARTIFICIAL MEMBRANES
10
CHROMATOGRAPHIC MODELING OF DRUG-PROTEIN
INTERACTIONS (HSA, AGP, Melanin, Keratin,
Collagen)
STERIC RESTRICTION
HYDROPHOBIC REGION
HYDROPHOBIC REGION

?
?
?
ANIONIC REGION




11
FUTURE PROJECTS AND GOALS
  • pH-Gradient HPLC a new method of
    chromatographic analysis of bioanalytes
  • Metabolomics metabolite profile differentiation
    using LC/CE/MS and bioinformatics
  • Analytical separation-identification platform
    LC-MC for the analysis of proteomes
  • - Relationship between the GPIIIa gene A1/A2
    polymorphism and blood platelet response to
    aggregation agonists among the North Poland
    population

12
SELECTED RECENT PUBLICATIONS
  • R. Kaliszan "Quantitative Structure-Retention
    Relationships (QSRR) in Chromatography", In
    Encyclopedia of Separation Science, Vol III, I.D.
    Wilson (Ed.), Academic Press, San Diego, 2000,
    pp. 4063-4075
  •  
  • D. Siluk, R. Kaliszan, P. Haber, J. Petrusewicz,
    Z. Brzozowski, G. Sut, Antiaggregatory activity
    of hypoglycaemic sulphonylureas, Diabetologia 45,
    1034-1037 (2002)
  •  
  • R. Kaliszan, P. Haber, T. Baczek, D. Siluk, K.
    Valko, Lipophilicity and pKa estimates from
    gradient high-performance liquid chromatography,
    J. Chromatogr. A 965, 117-127 (2002)
  •  
  • M. Markuszewski, R. Kaliszan, Quantitative
    structure-retention relationships in affinity
    high-performance liquid chromatography, J.
    Chromatogr. B 768, 55-66 (2002)
  •  
  • A. Nasal, D. Siluk, R. Kaliszan, Chromatographic
    retention parameters in medicinal chemistry and
    molecular pharmacology, Curr. Med. Chem. 10,
    381-426 (2003)
  • M.J. Markuszewski, P. Britz-McKibbin, S. Terabe,
    K. Matsuda, T. Nishioka, Determination of
    pyridine and adenine nucleotide metabolites in
    Bacillus subtilis cell extract by sweeping borate
    complexation capillary electrophoresis, J.
    Chromatogr. A 989, 293-301 (2003)
  • T. Baczek, R. Kaliszan, Predictive approaches to
    gradient retention based on analyte structural
    descriptors from calculation chemistry, J.
    Chromatogr. A 987, 29-37 (2003)
About PowerShow.com