New Investigators: Statement of Commitment

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New InvestigatorsStatement of Commitment

• Innovators of the future
• Fresh ideas and technologies to
• existing biomedical research
• problems
• Pioneer new areas of investigation

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Objectives

• Brief description of NIDP
• NIH Funding Mechanisms for New
• Investigators
• The Grants Process

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New Investigator Development Program - NIDP

• Develop and refine grant-writing skills
• Succeed in securing external funds

• Grants 101 Overview of policies/procedures
• Grants 102 In-depth 8-month workshop of
  grant-writing with mentored review process. Goal
  to submit grant application must be met!

http//research.uth.tmc.edu/nidp/
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Grants 102

• How to formulate a competitive
• grant application
• Monthly seminar/discussion sessions
• Series of steps to bring maximal
• focus to the process
• Mentored experience
• Final Draft of Grant Application for submission
• Workbook Grant Writers Seminars and
• Workshops, LLC (GWSW)

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New Investigator Development ProgramSteering
Team

• Lorraine Frazier, DSN.
• Associate Professor, SON
• Robert A. Kirken, PhD
• Assistant Professor, MS
• Kevin Morano, PhD
• Assistant Professor, MS
• Luis Ostrosky-Zeichner, MD
• Assistant Professor, MS
• Maureen Sanderson, PhD
• Associate Professor, SPH
• Martin Young, PhD
• Assistant Professor, IMM

• Melissa Proll, Ph.D.
• Director, Research Training and Compliance
• Sara Farese
• Coordinator, Research Training and Compliance
  Programs
• Rena D'Souza, DDS, PhD
• Professor of Orthodontics, DB
• Director, UT-TORCH
• Peter Davies, MD, PhD
• EVP for Research

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National Institutes of Health

• The National Institutes of Health (NIH) is the
  principal health research agency for the U.S.
  Federal Government. NIH is a component of the
  Department of Health and Human Services (DHHS.)
  The next two slides show the different
  components of DHHS and the different Institutes
  and Centers at NIH.

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National Institutes of Health

• Mission
• NIH conducts and supports basic, applied,
• clinical and health services research to
• understand the processes underlying
• human health and to acquire new
• knowledge to help prevent, diagnose, and
• treat human diseases and disabilities.

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National Institutes of Health

• How does NIH help accomplish this mission?
• NIH spends 80-85 percent of its total budget in
  support of biomedical and behavioral research and
  research training by more than 50,000 scientists
  located at more than 1,700 universities, research
  institutions, and medical centers across the
  United States and outside the United States.

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NIH Family
NHLBI
NINR
NCCAM
NIEHS
OD
NCI
NIAMS
CIT
NIDA
NEI
NIMH
CC
NIDDK
NLM
NINDS
NHGRI
NIDCR
NIBIB
NCMHD
NIA
NIDCD
NIAAA
NICHD
NIAID
NIGMS
NCRR
CSR
FIC
Extramural only
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NIH Funding Mechanisms

• Creating a Funding Track Record

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The A, B, Cs of Fs, Ks, and Ts
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The Alphabet
F

• Fellowship
• Individual NRSA
• Career
• Individual career development
• Training
• Institutional NRSA

K
T
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Basic Blocks
F

• F30, F32
• Individual NRSA Fellowship
• K08, K23, K25
• Individual Career Development
• T32
• Institutional NRSATraining

K
T
http//www.nidcr.nih.gov/funding/trainingandcareer
dev.asp
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What Next?
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R !
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Research Funding Tracks
K-award
Institutional Grant
Independent funding
Small research award
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Building Blocks

• Bridging to faculty positions
• Transition support
• Mid-career

Scholar Development and Faculty Transition Award
(K22) Mentored Clinician-Scientist Award (K23)
Independent Scientist Award (K02)
NRSA Senior Fellowship (F33) Mid-Career
Investigator Award (K24)
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K22
NIH

• Up to 5 years of support
• Postdoctoral fellowship
• Junior faculty
• Stipend
• Research budget
• Awarded prior to naming home institution

Academic Institution
Academic Institution
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Beyond Blocks
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Summary

• Many programs for funding new investigators
• NIH Research training and career development
  awards
• Other agencies and organizations
• Industry
• CHECK ELIGIBILITY

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Information about the NIH Grants Process
National Institutes of Health

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Grants and Cooperative Agreement Instruments

• How are they used?
• Grants
• NIH provides funds to support what was proposed
  in the application
• NIH provides assistance
• Cooperative Agreements
• NIH is a full partner in the project
• NIH provides assistance and substantial program
  involvement

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Applications for NIH Grants and Cooperative
Agreement Instruments
Grants and Cooperative Agreements are normally
submitted to NIH in three ways

• Program Announcement (PA) - Institute or Center
  is inviting grant applications in a general
  scientific area of research. There are generally
  no funds set aside for these projects.
• A Request for Applications (RFA) - one or more
  NIH Institutes and Centers invite applications in
  a well-defined scientific research area.
  Specific funds are set aside for the projects.
• CSR, NIH - as an Unsolicited Grant
  Application

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The NIH Extramural Team
Review
Grants Management
Program
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Scientific Review Administrator

• Performs administrative and technical
• review of applications
• Initial point of contact for applicants
• Selects reviewers
• Manages study sections and project
• site visits
• Prepares summary statements
• Provides any requested information
• about study section recommendations

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Program Administrator

• Responsible for the programmatic, scientific,
  and/or technical aspects of grants
• Initiates and encourages interest in scientific
  area of importance to match that of Institutes
  mission
• Is familiar with the peer review process
• Prepares funding recommendations
• Reviews annual progress of grants

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Grants Management Specialist

• Assures compliance with Federal law and NIH
  policies and procedures - are costs requested
  allocable, allowable and reasonable
• Analyzes applications prior to award
• Provides technical assistance, interprets NIH
  policies and Institute procedures
• Awards grant funds
• Reviews and responds to grantee prior
• approval and rebudgeting requests
• Assures documentation of official grant
  files

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Who to Call?

• Call Program Official for programmatic issues
  (i.e. which grant mechanism) or scientific issues
  (scientific progress)
• Call SRA prior to review only
• Call Grants Management Specialist for
  administrative matters (carryover of funds,
  additional slots, transfer of institution, etc.)
• Issues often overlap and will be shared
• internally

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Sample Application Number
Activity Code
Serial Number
Suffixes

• 1 R01 DE 012345 01 A1/S1

Application Type
Institute/Center
Year of Support
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Applications to NIH

• Unsolicited applications are sent to the Center
  for Scientific Review (CSR).
• Applications submitted to a PA or RFA should be
  sent to the appropriate office referenced in the
  PA or RFA announcement.
• The CSR mailing address isCENTER FOR SCIENTIFIC
  REVIEWNATIONAL INSTITUTES OF HEALTHROCKLEDGE II
  ROOM 1040 MSC-7710BETHESDA MD 20892-7710 USA
• Find PHS 398 at http//grants.nih.gov/grants/form
  s.htm

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NIH Guide for Grants and Contracts
How do I find out about NIH PAs and RFAs? The NIH
Guide Announces NIH Scientific Initiatives
provides NIH Policy and Administrative
Information. See http//www.nih.gov/grants/guide
/index.html
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NIH Guide for Grants and Contracts
Can I sign up for on a list serve to get
information about NIH PAs and RFAs? Each week
the NIH transmits via LISTSERV email the Table of
Contents (TOC) information for that week's issue
of the NIH Guide for Grants and Contracts.
Associated with each TOC entry is the WWW address
(URL) for each Guide article. To subscribe to
the Guide TOC Notification LISTSERV service,
please send a E-mail to listserv_at_list.nih.gov
and in the first line of the email message itself
- not the "Subject" line - provide the following
information subscribe NIHTOC-L your name where
your name is the name you wish to use. Your email
address will be automatically obtained from the
email message you send to the LISTSERV.
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NIH Guide for Grants and Contracts, continued

• When preparing an application an investigator
  should
• Read and carefully follow instructions(See NIH
  GUIDE, PHS 398 at http//grants.nih.gov/grants/fo
  rms.htm)
• Write a concise, reviewer-friendly application.
  Never assume that reviewers will know what you
  mean
• Refer to literature thoroughly
• State rationale of proposed investigation and
  clearly explain the methodology
• Include well-designed tables and figures
• Present an organized, lucid write-up
• If possible, have someone who has experience
  working with NIH review the completed application

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Useful Web Site to Help Prepare a Grant
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Applications Submitted to NIHare Peer Reviewed
The review of grant and cooperative agreement
applications involves two sequential levels of
review for each application. In this system, the
scientific assessment of proposed projects is
kept separate from policy decisions about the
scientific areas to be supported and the level of
resources to be allocated. The first review, the
evaluation of scientific and technical merit, is
conducted by one of many chartered scientific
review groups, referred to as SRGs, managed by
the NIH Center for Scientific Review (CSR) or by
the institutes.
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Applications Submitted to NIH are Peer Reviewed,
continued
The group or panel, established according to
scientific disciplines or medical specialties,
may consist of as many as 16 to 20 members who
are primarily non-Federal scientists with
expertise in various disciplines and areas of
research. The primary requirement for serving on
an SRG is competence as an independent
investigator in a scientific discipline. Other
factors such as respect among peers and quality
of research accomplished are also important.
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Applications Submitted to NIH are Peer Reviewed,
continued
The reviewers study each application individually
before the meeting and for each application,
some reviewers are assigned to prepare written
critiques. Those projects deemed most
competitive, approximately the upper half, are
fully discussed and given a priority score based
on the scientific merits of the project. The
second review is performed by National Advisory
Boards or Councils, hereafter "councils," of the
NIH funding components. This panel of 12-18
members consists of scientists and laypersons
chosen for their interest in matters related to
health and disease.
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Applications Submitted to NIH are Peer Reviewed,
continued
Council members review the applications against a
broad background of considerations including
relevance, program goals, and available funds of
the institute they also consider the
appropriateness of the scientific review
conducted previously by the SRG. The Dual Peer
Review System and an example of a complete grant
cycle is shown on the next two slides.
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Dual Review System for NIH Grant Applications
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Review Process for A Grant Application
GRANTS 102
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For More Information
NIH Office of Extramural Researchhttp//grants1
.nih.gov/grants/oer.htm
FIC website http//www.fic.nih.gov
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NEW WEBSITE!

• http//grants1.nih.gov/grants/new_
• investigators/index.htmdefinition

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We shall not cease from exploration and the end
of all exploring will be to arrive where we
started and know the place for the first
timeT.S.Elliot
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Questions????