Mesenchymal Stem Cells | Dr. David Greene Arizona

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Mesenchymal Stem Cells
Dr. David Greene Arizona
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Mesenchymal Stem Cells the Blood-Brain Barrier
(BBB)
Modern studies suggest that Mesenchymal stem
cells (MSCs) when administered intravenously, can
cross the blood-brain barrier (BBB) leading to
various regenerative effects
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Do mesenchymal stem cells administered via IV
cross the blood-brain barrier (BBB)?
Mesenchymal stem cells (MSCs) intrinsically
possess unique features that help them migrate
towards areas of inflammation. MSCs secrete
various types of secretomes to induce nerve
regeneration and pain-relieving effects at
inflammatory sites
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What is the blood-brain barrier?
The blood-brain barrier (BBB) is a dispersion
barrier, which prevents the entry of most
compounds from the blood to the brain. According
to Ballabh, the barrier is highly particular,
meaning it only allows certain substances to
cross from the bloodstream into the brain. This
protects the brain from toxins that can
potentially damage neurons
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Stem cells cross the blood-brain barrier in an
animal stroke model
Mesenchymal stem cells represent a great
potential to reverse neuronal damage associated
with CNS diseases such as Multiple Sclerosis,
Parkinson's disease (PD), and Alzheimer's disease
(AD)
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What makes mesenchymal stem cells (MSCs) so
special?
Mesenchymal stem cells (MSCs) are an especially
attractive therapeutic agent due to their ease of
isolation, established safety, and potential to
target multiple pathways involved in neuronal
regeneration. MSCs are widely used in the
treatment of various diseases due to their
self-renewable, differentiation,
anti-inflammatory, and immunomodulatory
properties. In-vitro (performed in a laboratory
setting) and in-vivo (taking place in a living
organism) studies have supported the
understanding mechanisms, safety, and efficacy of
MSC therapy in clinical applications
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Homing mechanisms of mesenchymal stem cells
(MSCs)
One of the key benefits of mesenchymal stem cells
is their ability to target specific areas of
concern due to their intrinsic homing
capabilities. Mesenchymal stem cell homing, when
administered systemically can be defined as
exiting circulation and migrating to the injury
site
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