Natural Cycle IVF (In-Vitro Fertilisation)

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Natural / Mild IVF

• When is Natural IVF right for you?

www.drsuparnabanerjee.com
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Natural cycle IVF (in vitro fertilisation) simply
means the of collection and fertilization of the
one egg (a single oocyte) that a woman releases
during her normal monthly menstruation
cycle.This method can appeal to couples because
it provides a lower risk, patient friendly
alternative to conventional IVF treatment as
there are no medications required to stimulate
the womans ovaries to induct egg production.
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Every Egg Counts

• Even an increase from 1 egg collected (the likely
  maximum in a natural cycle) to 2 or 3 eggs
  significantly improves chances of IVF success.

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When is Natural IVF right for you?

• In general, the doctors at The Ankur Fertility
  Clinic advise patients to undergo a stimulated
  cycle because the success rates for IVF treatment
  improve with increasing numbers of eggs
  collected.
• However, in those who are naturally ovulating and
  medication is unlikely to help recruit more than
  this one egg, "natural IVF" may be most
  appropriate. This is particularly the case in
  those with a very low ovarian reserve or in those
  who have previously used high doses of medication
  but still only achieved a single follicle.
• As with mild IVF it may also be offered to those
  who have concerns over the side effects of
  medication, a medical problem where stimulation
  may not be possible or to absolutely eliminate
  OHSS risk.

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When might Natural IVF NOT be right for you?

• In general, the doctors at The Ankur Fertility
  Clinic advise patients to undergo a stimulated
  cycle because the success rates for IVF treatment
  improve with increasing numbers of eggs
  collected.
• However, in those who are naturally ovulating and
  medication is unlikely to help recruit more than
  this one egg, "natural IVF" may be most
  appropriate. This is particularly the case in
  those with a very low ovarian reserve or in those
  who have previously used high doses of medication
  but still only achieved a single follicle.
• As with mild IVF it may also be offered to those
  who have concerns over the side effects of
  medication, a medical problem where stimulation
  may not be possible or to absolutely eliminate
  OHSS risk.

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When might Natural IVF NOT be right for you?

1. 44 of Natural Cycles DO NOT result in eggs being
   collected.
2. 57 of Natural cycles DO NOT result in embryos
   being transferred.
3. The overall livebirth rate for Natural IVF is lt5
4. It takes almost 5 natural cycles for every 1
   stimulated cycle to achieve a livebirth.
5. There is no difference in later pregnancy risks
   such as preterm delivery or low birthweight.

Source (HFEA data 1991-2011 Sunkara et al,
Human Reproduction, 2016) This clearly
demonstrates that if you include all cycles (both
stimulated and natural) at these clinics the
overall success rates are in fact 15.8 and 23.0
for LB/embryo and LB/cycle rather than the
figures of 18.4 and 32.5 that are reported for
headline success.
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Mild IVF

• Mild stimulation IVF is one of the many tools at
  our disposal to minimize risk and is, in essence,
  just the sensible choice of a lower starting dose
  in a protocol that minimises hyperstimulation
  risk.
• So, in patients with a good ovarian reserve and a
  higher likelihood of producing a good number of
  eggs, there is no benefit of using high doses of
  stimulation drugs. It is particularly suitable
  for women with polycystic ovarian syndrome who
  have a high risk of OHSS and in those with other
  medical conditions where risk of OHSS needs to be
  minimized.

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Mild IVF
Along with the use of mild IVF regimes, we also
minimize OHSS risk by

1. Optimising starting dose using a variety of
   ovarian reserve tests
2. Antral follicle count on scan
3. Measurement of antimullerian hormone (AMH)
4. Measurement of FSH levels

Endocrine monitoring throughout treatment with
regular measurement of hormone levels to allow
appropriate dose adjustments if needed. The use
of alternative "agonist trigger" injection where
needed to mature eggs before collection that can
virtually eliminate OHSS risk.
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Segmenting treatment cycles by freezing all
embryos if necessary and transferring in a future
natural cycle thereby allowing the body to
recover and avoiding OHSS risk.Mild regimes are
therefore a vital tool in our armory, that are
used in a significant proportion of cycles.
Choice of protocol is always made after
discussion of all relevant factors with our
patients to help them decide whether to go for
low, medium or high stimulation based on their
condition and the risks of potential side effects.
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Contact Us!!
Ankur Fertility Women's Clinic Dr. Suparna
Banerjee 23A/661A , New Alipore, Block O,
Kolkata 700053 Opening Hours We are open on
all weekdays. Monday to Friday  1000 AM
1000 PM Saturday  1000 AM 500 PM To
consult Dr. Suparna Banerjee, please book an
appointment by  91 90513 71257 / 91 6290 627
536.
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ThankYou