New HPV Treatment Could Eliminate CIN

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New HPV Treatment Could Eliminate CIN
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Theres an exciting development in the treatment
of HPV. Until now, there has only been
a preventative vaccine that works best when
administered before someone becomes sexually
active. However, researchers are studying a new
immune-based therapy that may be capable of
eliminating the virus from tissues in the body
after its already been contracted.
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Cervical Precancerous Lesions

• CIN 2 and CIN 3 lesions are always caused by HPV.
  Previously, the only way to treat CIN 2 and CIN 3
  lesions involved removing a cone-shaped piece of
  the cervix, sometimes called a LEEP.
• This procedure shortens the cervix and leads to
  scarring, which, in turn, can lead to problems
  getting pregnant, problems during childbirth, and
  possible miscarriages during the second
  trimester.
• Additionally, women who have this procedure have
  a very high risk of developing cervical cancer
  over the next 20 years if they do not continue to
  be screened.

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Cervical Precancerous Lesions

• So far, this new type of vaccine has been tested
  in one study involving women with cervical
  precancerous lesions resulting from an HPV
  infection. Cervical precancerous lesions (known
  as cervical intraepithelial neoplasia or CIN) are
  separated into three grades of severity
• CIN 1 lesions typically clear up on their own.
• CIN 2 can clear up on their own, but often
  progress to CIN 3.
• CIN 3 lesions are the most severe, and less than
  half of CIN 3 lesions will become cancer within
  30 years.

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The Study
The study consisted of 192 women, all of whom had
either CIN 2 or CIN 3 precancerous cervical
lesions. Study participants were randomly
separated into two groups. The first group was
comprised of 129 women who received the therapy
and the second group had 63 women who received
the placebo. Regardless of group, all of the
women received an injection into their thigh once
a week for three weeks. Six months after they
received their injections, all of the study
participants underwent surgery to remove the
precancerous cells.
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The Results
Participants who received the vaccine were twice
as likely as those who received the placebo to
see their CIN eradicated, regardless of the type
of CIN. Additionally, when it came to the more
severe stage, somewhere between 15 to 36 of
women with CIN 3 saw their CIN completely
eliminated, while none of the women with CIN 3 in
the placebo group did. Researchers followed
these women for three years after receiving the
vaccine, and they found that the long-term
success was better for those who received the
vaccine than those who had the placebo, with more
women who had the vaccine remaining completely
clear of HPV. Visit for more info
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te-cin/
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