Afinitor 10mgAfinitor 10mg - Anticancer drugs | view uses, side effects and price | MHP

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AFFINITOR 10 MG EVEROLIMUS 10MG
MILLIONHEALTHPHARMA
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DESCRIPTION
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• Afinitor 10mg is a derivative of Rapamycin
  (sirolimus) and works similarly to Rapamycin as
  an mTOR (mammalian target of rapamycin)
  inhibitor.
• It is normally used as an immunosuppressant to
  prevent rejection of organ transplants.
• In a similar fashion to other mTOR inhibitors
  Everolimus' effect is solely on the mTORC1
  protein and not on the mTORC2 protein.

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PRESCRIBE INFORMATION

• Afinitor 10mg tablets are mainly indicated for
  the treatment of Renal carcinoma.
• Afinitor 10mg tablets are mainly indicated for
  the treatment of Breast carcinoma.
• Afinitor 10mg tablets are mainly indicated for
  the treatment of Brain carcinoma.
• Afinitor 10mg tablet is also used in various
  advanced stage cancer in stomach, intestines or
  pancreas.

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MECHANISM OF ACTION

• Everolimus is an mTOR prohibitor, joints at high
  compatibility to FK506 binding protein 12, via
  producing drug complex whichinhibits the specific
  of mTOR.
• This inhibitiondecreases the activity of
  effectors downstream, that may cause blockage of
  cell progression from G1 into S phase,
  subsequently causes cell growth arrest and
  apoptosis

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ABSORPTION

• The high plasma concentration time of Everolimus
  is 1 to 2 hours.
• The effect of food with Afinitor 10mg that with
  heavy meal Reduction of systemic exposure
  to Afinitor 5mg 10mg, and the high blood plasma
  concentration by 54.

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Affinitor 10mg

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DISTRIBUTION

• Afinitor 10mg human plasma protein bound with the
  range of 74.

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METABOLISM

• The metabolism of Everolimus is occurred in
  liver, which is a substrate of CYP3A4.
• The metabolites of Everolimus
• Three monohydroxylated metabolite,
• Two hydrolytic rings opened products,
• Phosphatidylcholine conjugate of Everolimus.

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EXCRETION

• The major route of elimination
• 5 in urine the parent compound has been
  detected in urine or feces.
• The half-life period of Everolimus is relatively
  30 hours

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DOSAGE MANAGEMENT

• In breast cancer, renal cell cancer, pancreatic
  cancer, Neuro endocrine cancer
• The prescribed dosage is 10mg should be taken as
  a single dose.
• In Brain or intracranial cancer
• The prescribed dosage of Afinitor is 4.5mg/m2
  orally as a single dose.

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• In pediatric
• The usual pediatric dosage of Afinitor in brain
  or intracranial tumor is 4.5mg/m2 should be taken
  orally as a single dose.
• Afinitor  10mg tablet should be administered with
  or without food.

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PRECAUTIONS

• Lymphomas
• Increased exposure of skin cancers, patient may
  protect from UV light
• Serious infections
• Patients receiving Afinitor 10mg have high risk
  of acquiring various infections related to
  bacteria, virus, and fungi. Anti-microbial agents
  are preferred for the suspected patients.

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• Hepatic artery thrombosisIn liver transplant
  patients, Afinitor 10mg therapy should not be
  recommended.
• Nephrotoxicity
• Renal function should be monitored frequently
  caution should be taken while using Afinitor 10mg
  in renal impaired patients.
• Angioedema
• This may have occurred in the patients receiving
  concomitantly Afinitor 10mg with Angiotensin
  converting enzyme agents

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Hyperlipidemia
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• Hyperlipidemia
• Patient getting Afinitor 10mg tablet with lipid
  lowering drugs causes increasing in plasma
  concentration of these drugs causes
  hyperlipidemia
• Interstitial lung disease
• Occurred in Afinitor 10mg therapy
• Interact with grape juice
• Causes increasing blood levels of Everolimus
  avoid these concomitants.

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SIDE EFFECTS

• Hypersensitivity reactions
• Lymphomas other malignancy
• Serious infections
• Kidney graft thrombosis
• Hepatic artery thrombosis
• Nephrotoxicity
• Hyperlipemia

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• Angioedema
• Interstitial lung disease
• Thrombocytopenia
• Male infertility
• Proteinuria
• New commencement of diabetes .

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• PREGNANCY
• Pregnancy category C Afinitor 10mg is needed only
  by the patients after knowing the benefits to the
  mother outweighs the risk to fetus.
• LACTATION
• Breast feeding should not be suggested
• STORAGE
• Afinitor 10mg tablet should be kept at 25C
• Keep the tablet away from moisture, heat and
  light
• Dispense only in original container

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• MISSED DOSE
• If patient failed to take a single dose, patients
  must consult with medical practitioner and follow
  the instructions given by them.
• Or the missed dose should be avoiding and follow
  the regular dosing schedule.
• OVERDOSAGE
• The over dosage of Everolimus is rarely occur, in
  case of over dosage patient must be provide with
  supportive measures. The acute toxicity of
  Everolimus over dosage should be monitored.

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CONTACT US

• PHONE NO    91-9940472902
• EMAIL              millionhealthpharmaceuticals_at_g
  mail.com 
• WEBSITE        https//millionpharma.com/everolim
  us-10mg.php

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