Improved Progression-Free-Survival in Renal Cell Cancer with Everolimus Treatment

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Improved Progression- Free Survival in Renal
Cell Cancer with Everolimus Treatment
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Renal Cell Cancer or Renal Cell Carcinoma or RCC
is the most common form of kidney cancer that is
diagnosed in adults. RCC is fast growing and
can often spread from the kidney to nearby
organs. The kidneys help in getting rid of waste
and regulating fluid balance through tiny tubes
known as tubules. RCC forms when the abnormal
cancer cells start growing rapidly in the lining
of tubules.
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Its pathogenesis is related to the altered
cellular responses to hypoxia. In this
response, the mTOR protein (mammalian target of
rapamycin) signalling pathways are
implicated. Everlolimus / Afinitor cost
information
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Everlolimus Mechanism of Action Everlolimus
(Brand Afinitor) presents a therapeutic option
for treating advanced stage RCC. It is an orally
taken targeted therapy medication. It works by
blocking the protein mTOR which plays a vital
role in the regulation of blood vessel growth and
regulation the division of the cancer cells.
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• Everlolimus / Afinitor uses
• Everolimus is approved by the US Food and Drug
  Administration (FDA) for treating advanced renal
  cell cancer. Other uses of Everolimus as approved
  the FDA include
• Progressive advanced tumours (pancreatic origins)
  in adult patients
• Renal angiomyolipoma
• Tuberous sclerosis complex (TSC) in patients that
  do not require immediate surgery
• subependymal giant cell astrocytoma which is
  associated with TSC patients who have not
  received curative surgery

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Everolimus is also the first mTOR inhibitor
approved by the FDA to treat post-menopausal
women with HER2-negative or advanced hormone
receptor (HR) positive breast cancer. Clinical
Research A clinical trial was conducted by
Memorial Sloan Kettering Cancer Center (MSKCC)
and other institutions in Europe to test the
effectiveness of everolimus / afinitor in
patients with advanced renal cell cancer.
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400 patients were selected for this clinical
trial. In this group of patients, the cancer
had progressed even after treatment with
Sunitinib (Brand Sutent) or Sorafenib (Brand
Nexavar) or both of these medications. The
patients were randomly assigned to be treated
with either everolimus / afinitor or a placebo or
inactive substitute.
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Conclusion It was found that the median
progression-free survival was 4 months in
patients treated with everolimus which was an
improvement when compared to the median 1.9 months
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• Everolimus / Afinitor side effects
• Some everolimus side effects include
• Unusual bleedings and bruising
• Low blood cell count or anemia, signs unusual
  tiredness, light headedness, shortness of breath,
  cold hands and feet and/or pale skin
• High levels of blood sugar, signs increased
  urination, dry mouth and thirst, fruity breath
  odour, blurred vision and/or headaches
• Wheezing, sudden coughing and/or breathing
  problems
• Slow healing of wounds, surgical incision,
  redness, warmth, swelling and/or oozing

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• Some of the more common symptoms may include
• Urination problems
• High blood pressure and cholesterol increase or
  triglycerides
• Nausea, diarrhoea, constipation, stomach problems
  and/or headaches
• Swelling in legs, ankles and/or feet

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• Everolimus / Afinitor Dosage
• Everolimus / Afinitor tablets comes in the
  following doses
• Everolimus (Brand Afinitor) 0.25mg tablets
• Everolimus (Brand Afinitor) 0.5mg tablets
• Everolimus (Brand Afinitor) 0.75mg tablets
• Everolimus (Brand Afinitor) 5mg tablets
• Everolimus (Brand Afinitor) 10mg tablets

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Everlolimus cost information The information
provided on the page is meant for the purpose of
being helpful and educational. It should not be
considered as medical advice.   Afinitor,
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