IgA Nephropathy: Causes, Symptoms, Daignosis, Prevention and Treatment - PowerPoint PPT Presentation

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IgA Nephropathy: Causes, Symptoms, Daignosis, Prevention and Treatment

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Title: IgA Nephropathy: Causes, Symptoms, Daignosis, Prevention and Treatment


1
IgA Nephropathy
2
What is IgA nephropathy?
  • IgA nephropathy is a chronic kidney disease.
    This disease progresses over 10 to 20 years, and
    can lead to end-stage renal disease. It is caused
    by deposits of the protein immunoglobulin A (IgA)
    inside the filters (glomeruli) in the
    kidney.Generally these glomeruli filter waste
    and extra water from the blood and send them to
    the bladder as urine. Though, the IgA protein
    prevents this filtering process. This may lead to
    the following
  • Blood and protein in the urine (hematuria and
    proteinuria)
  • Swelling in the hands and feet (edema)

3
What causes IgA nephropathy?
  • The IgA protein is a normal part of the human
    body's immune system. It is not known what causes
    IgA deposits in the glomeruli. In more than 15
    of affected families, it is inherited.Some
    people who inherit the gene may not have any
    symptoms, but could pass the gene on. Men are
    affected more often than women.

4
How is IgA nephropathy diagnosed?
  • Your doctor will review your medical history and
    do a physical exam. Other tests may include
  • Blood pressure checks
  • Cholesterol test
  • Checking for protein in the urine
  • Checking for protein in the blood
  • Kidney biopsy (to identify IgA deposits). To
    perform this test, a sample of kidney tissue is
    extracted and examined under a microscope.

5
What are the symptoms of IgA nephropathy?
  • IgA nephropathy is a silent disease that can go
    inherited for years. It can occur at any age, but
    symptoms most often start before the age of
    40.The most common symptom is blood in the
    urine (hematuria). This condition takes many
    years to progress to the stage where it causes
    problems. These further includes swelling,
    recurrent upper respiratory infections, or
    intestinal disease.People with IgA nephropathy
    may also have flank pain and a low fever. Very
    rarely, blood pressure can become dangerously
    high. 

6
What is the treatment for IgA nephropathy?
  • Your doctor will figure out the best treatment
    based on
  • How old you are
  • Your overall health and past health
  • How sick you are
  • How well you can handle specific medicines,
    procedures, or therapies
  • How long will the condition last
  • Your opinion or preference

7
What is the treatment for IgA nephropathy?
Continue
  • Treatment may include
  • Medicines
  • Blood pressure medicines, like ACE inhibitors -
    These medicines help in lowering down the blood
    pressure and protect the kidneys. They also help
    to prevent protein loss in the urine. Pregnant
    women should not take these medicines.
  • Corticosteroids - These reduce inflammation and
    scar tissue inside of the kidney.
  • Prescription strength fish oil - This helps to
    reduce inflammation and damage within the kidney

8
What is the treatment for IgA nephropathy?
Continue
  • Cholesterol-lowering medicines such as statins -
    People with kidney damage are at a higher risk
    for stroke and heart attack. Controlling
    cholesterol can help reduce the risk for both.
  • Other treatments
  • Diet changes to reduce fat and cholesterol. These
    can cause build-up of plaque in the kidney
    arteries and further damage to the kidneys.
  • Stop smoking
  • Exercise and maintaining a normal body weight
  • High fluid intake

9
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