Paget’s Disease Of The Bone: Symptoms, Causes, Diagnosis and Treatment - PowerPoint PPT Presentation

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Paget’s Disease Of The Bone: Symptoms, Causes, Diagnosis and Treatment

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Paget’s disease of the bone is a long-term bone disorder resulting in the enlargement and deformation of bones. Paget’s disease is the second most common type of bone disorder in the world. – PowerPoint PPT presentation

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Title: Paget’s Disease Of The Bone: Symptoms, Causes, Diagnosis and Treatment


1
Pagets Disease
2
Pagets Disease
  • Pagets disease of the bone is a long-term bone
    disorder resulting in the enlargement and
    deformation of bones. Pagets disease is the
    second most common type of bone disorder in the
    world. The excessive breakdown of tissue due to
    Pagets disease causes weak bones, fracture, and
    deformities. There are two types of Pagets
    disease of the bone Polyostotic (when multiple
    bone areas are affected) and Monostotic (when
    single area of bone is affected). Irregularities
    in the bone modelling process cause Pagets
    disease of bone. Pagets disease of the bone
    affects the normal skeletal structure of the
    body. 

3
Causes of Pagets disease of the bone 
  • The exact cause of Pagets disease is still
    unknown. Some of the believed causes of Pagets
    disease are 
  • Genetic mutations
  • Measles virus attacks
  • Osteoclast cells malfunction
  • Environmental factors
  • Resorption of bone cells

4
Symptoms
  • The symptoms of Pagets disease depend on the
    area of the body part affected. However, symptoms
    of Pagets disease occur slowly over time and
    some patients may not feel any signs and symptoms
    of the disease.  The most common symptom of
    Pagets disease is persistent pain in the joints.
    If Pagets disease is left untreated, it may
    contribute in the development of arthritis. The
    development of Pagets disease in the skull bone
    often results in severe headaches, nausea, vision
    problems, hearing loss, tingling and numbness
    around the face. The disease causes bones to
    transfer more than required calcium in the blood.
    The excessive amount of calcium in the blood
    results in extreme weakness, constipation, and
    loss of appetite. Another serious symptom of
    Pagets disease is change in the structure of
    bone. It can make your thighs, legs, and forehead
    look bigger than actual. 

5
Pagets Disease
6
Diagnosis of Pagets disease of the bone 
  • Diagnostic tests for Pagets disease may
    include 
  • CT (Computerized Tomography) - It is a technique
    in which several X-rays are taken from a
    different angle and combined later to make
    detailed images of the affected bones.
  • MRI (Magnetic Resource Imaging) - It is an
    imaging test in which high frequency magnetic and
    radio waves are used to get detailed images of
    the affected bones.
  • Bone scan - It involves the use of a small amount
    of radioactive solution, known as a tracer. This
    tracer is injected into the patients vein. A
    special camera is used to take pictures of areas
    that absorbed tracer.

7
Treatments
  • There is no permanent cure for Pagets disease
    its treatment can only help in the reduction of
    symptoms. Possible treatment of Pagets disease
    is 
  • Medicines such as, acetaminophen and
    bisphosphonates provide relief from the pain,
    prevent bone loss, and control level of calcium
    in the body.
  • Physical therapy, routinely exercise and
    certain vitamin D supplements prevent the Pagets
    disease from developing further.
  • In particular cases an osteotomy procedure is
    performed. Osteotomy is a surgical procedure in
    which a segment of bone is removed to correct a
    misalignment.

8
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