Inflammation, Gut Health and Food Sensitivities - The Obesity Connection - Voice Over Presentation

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• Gut Health,
• Food Sensitivities
• and Weight Management
• Susan Drake, MS, RDN
• sdrake_at_cellsciencesystems.com
• Lea Russell, MBA, RDN
• lrussell_at_cellsciencesystems.com

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CHRONIC DISEASE Its Never One Thing!
Lifestyle Dietary Factors
Environmental Factors
Gut Dysbiosis
Inflammation
Food Sensitivities Pathogens
Obesity
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Inflammation Chronic Disease Gut Integrity
Matters

• 95 of all chronic disease has an inflammatory
  component.
• Gut integrity prevents or sets the stage for food
  sensitivity, immune dysfunction, inflammation,
  chronic disease.
• Determining removing foods that cause
  inflammation can be an important part of breaking
  the cycle of chronic inflammation
• Improving gut health reduces inflammation and may
  decrease obesity.

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Gut Microbiome Functions

• Contains over 1000 species of bacteria, yeast and
  parasites
• Synthesis of vitamins (K, B12)
• Metabolism
• Renewal of gut cells - lining
• Development of the immune system
• Motility

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Normal Gut
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Leaky gut is a gateway to chronic disease
NSAIDs
Food allergies Intolerances
Immune system dysregulation
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Some Causes of Leaky Gut
or .... Losing Barrier Integrity

• Chronic Stress
• Intestinal Infections
• Small intestine bacterial overgrowth
• Environmental contaminants
• Excess alcohol
• Poor diet
• Diet soda
• NSAIDS, steroids, antibiotics, and other
  medications

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How do we Improve Gut Microbiota?

• Eat a clean diet
• Gut health supplements
• Decrease stress
• Fecal transplant?
• Determine and eliminate food sensitivities

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The Connection Between Food Sensitivities Weight

• Food sensitivities alter your biochemical
  balance, influencing appetite controlling
  hormones like serotonin and ghrelin.
• Result abnormal cravings for simple sugars and
  carbohydrates.
• Your metabolism is disrupted resulting in less
  efficient energy production and increased fat
  storage.
• Food sensitivities provoke immune mediated
  vasculitis, which causes fluid to leak from your
  capillaries into surrounding connective tissues.
• Result water retention and inflammation.

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Food Allergy or a Sensitivity

• Food Allergy
• Food Sensitivity

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Allergy or Food Sensitivity

• Anaphylactic Allergy
• Immediate/severe symptom onset Specific immunity
• Genetic/Exposure related IgE mediated
• Induce Mast cells/Basophils to release Histamine
• Skin test/RAST
• Peanut, milk, egg, fish, shell fish, wheat, nuts,
  soy

• Sensitivity
• Genetic/Exposure Related
• Delayed symptom onset
• Symptoms 4 72 hours post consumption
• Generally less severe but chronic symptoms
• Altered Gut Integrity

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• Who
• Should
• Test?

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Food Sensitivity Testing

• Identifies substances that provoke a negative
  cellular response.
• Dose dependent with Delayed onset.
• Any food can cause symptoms. With repeated
  consumption, can develop into a chronic
  systematic inflammatory response and the constant
  activation of the immune system.
• Single elimination trials take a very long time.
• NO universal bad or good foods very patient
  specific.

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Cellular Degranulation Reaction (inducing
mediator release)
The reactive white blood cells release chemical
mediators that affect target organs and may
result in symptom manifestations typical in many
chronic conditions.
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ALCAT BLOOD TEST

• Most accurate way to identify foods/chemicals
  that provoke an immune response.
• Direct link to systematic inflammation and
  constant activation of the immune system
  difficulty losing weight.
• Test over 450 antigens, including Foods,
  Environmental Chemicals, Food Additives
  Colorings, Molds, Functional Foods Medicinal
  Herbs, Pharmocoactive agents.
• Proven results with patient compliance to
  recommended food avoidance rotation diet.

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Effect of Alcat-Based Food Elimination on
Inflammatory Markers, Body Composition and
Medical SymptomsLukaszuk J, Shokrani M,
Hoppensteadt J, Umoren J.

• Pre/post test double blind study Tx (n87) and PL
  (n46).
• Follow 4 week elimination diet based on Alcat
  results.
• Blood samples, body composition and medical
  symptoms completed days 1 and 30.

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Alcat Study Conclusions

• Elimination of inflammatory foods have a positive
  impact on Body Mass Index.
• Alcat results may positively influence
  inflammatory responses, body composition and
  well-being.

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The Short Term Efficacy of the ALCAT Test of Food
Sensitivities to Facilitate Changes in Body
Composition and Self-Reported Disease Symptoms A
Randomized Controlled Study

• The ALCAT Test (exp. group) resulted in highly
  significant improvements in body composition and
  self-reported disease symptoms.
• 98 of those following the ALCAT plan either lost
  weight and/or improved body composition.

There was a marked reduction in cravings in
general, especially for sweets.
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Take Home Messages

• There is a connection between gut health and
  weight.
• Reducing inflammation is the key to overall
  health.
• Food and other exposures interact with our gut in
  either a positive or negative way.
  
• ALCAT individualizes your dietary regimen.
• Diet and lifestyle modifications improve gut
  health and reduce inflammation to maintain
  permanent weight loss.