Can Green Tea Improve the Down Syndrome Symptoms? - PowerPoint PPT Presentation

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Can Green Tea Improve the Down Syndrome Symptoms?

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Interesting revelation from Phase II clinical trial suggests that Green tea can improve the intellectual capacities of the Down syndrome patients. – PowerPoint PPT presentation

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Title: Can Green Tea Improve the Down Syndrome Symptoms?


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Can Green Tea Improve the Down Syndrome Symptoms?
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  • Interesting revelation from Phase II clinical
    trial suggests that Green tea can improve
    the intellectual capacities of the Down syndrome
    patients.

3
  • Scientists from Centre for Genomic Regulation
    (CRG) made an interesting revelation about the
    link between one of the compounds present in the
    healthy morning refreshment- Green tea and
    improvement in the intellectual capacities of a
    person with Down syndrome.

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  • Epigallocatechin gallate (EGCG) is a catechin
    compound which is present in excess in tea.
    DYRK1A (Dual-Specificity Tyrosine-(Y)-Phosphorylat
    ion Regulated Kinase 1A) is an enzyme encoded by
    DYRK1A gene in humans which are considered as a
    gene responsible for the learning defects
    associated with

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  • Down syndrome and also affects the brains
    ability to change in a normal way
    (neuroplasticity).  In the clinical trials, EGCG
    has been shown to improve the cognitive functions
    of the patients with Down syndrome.

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  • The Phase II study was led by Rafael de la Torre
    and team on 84 patients of age group 16-34 years
    at the IMIM-Hospital del Mar Medical Research
    Institute. The patients were given EGCG (9 mg/kg
    per day) or placebo along with the cognitive
    training for 12 months and later followed up for
    6 months after treatment was discontinued.

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  • Patients treated with EGCG significantly scored
    higher in visual recognition memory, inhibitory
    control and adaptive behaviour. EGCG is known for
    the inhibition of excess DYRK1A gene in mice in
    earlier studies and now it was also shown
    effective in humans with Down syndrome. The study
    was published in The Lancet Neurology.

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  • WHO has reported that 1 out of 1000 persons is
    affected with Down syndrome globally. Down
    syndrome is a genetic disorder caused due to the
    presence of three copies of chromosome 21 which
    leads to the overexpression of the genes present
    on this chromosome. DYRK1A is one of the genes
    present in chromosome 21.

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  • The researchers of IMIM and CRG demonstrated that
    the compound EGCG functions in inhibiting the
    excess function of DYRK1A which leads to the
    improvement of the cognitive functions of the
    brain when given along with the cognitive
    training.

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  • To reinforce the effect of EGCG and cognitive
    training on the cognitive functions of the
    patients with Down syndrome, Phase III trial will
    be performed on a larger group of Down syndrome
    patients.

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  • For More Update, Visit Us

http//medgenera.com/
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