Generic Morphine Sulphate 50mg Vial - PowerPoint PPT Presentation

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Generic Morphine Sulphate 50mg Vial

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Generic Morphine Sulphate MAGNUS MR 30mg/2ml / Amps Therapeutic Class:Narcotic analgesic Composition:Magnus MR 2ml vial containing morphine sulphate 30 mg/2mlDescription:Morphine applies an agonist effect at saturable opioid receptors in the CNS and other tissues & acts as opioid analgesic. – PowerPoint PPT presentation

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Title: Generic Morphine Sulphate 50mg Vial


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Generic Morphine Sulphate 50mg / Vial
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  • Generic Morphine Sulphate MAGNUS MR 30mg/2ml /
    Amps Therapeutic ClassNarcotic analgesic
    CompositionMagnus MR 2ml vial containing
    morphine sulphate 30 mg/2mlDescriptionMorphine
    applies an agonist effect at saturable opioid
    receptors in the CNS and other tissues acts as
    opioid analgesic.

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  • Morphine is an analgesic drug used to treat acute
    and chronic pain. Obesity is frequently
    associated with pain of various origins (e.g.
    arthritis, fibromyalgia, cancer), which increases
    the need for analgesic drugs. Obesity changes
    drug pharmacokinetics, and for certain drugs,
    specific modalities of prescription have been
    proposed for obese patients.

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  • However, scant data are available regarding the
    pharmacokinetics and pharmacodynamics of morphine
    in obesity. Prescription of morphine depends on
    pain relief but the occurrence of respiratory
    adverse effects correlates with obesity, and is
    not currently taken into account.

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  • Variations in the volume of distribution,
    elimination half-life and oral clearance of
    morphine, as well as recent advances in the
    respective roles of drug-metabolizing enzymes,
    catechol-O-methyltransferase and the µ opioid
    receptor in morphine pharmacokinetics and
    pharmacodynamics, may contribute to differences
    between obese and non-obese patients.

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  • In addition, drug-drug interactions may alter the
    disposition of morphine and its glucuronide
    metabolites, which may either increase the risk
    of adverse effects or reduce drug
    efficacy.Indications

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  • Severe chronic pain or pain resistant to other
    analgesics, in particular pain associated with
    cancer.DosageAdultsRecommended dosage is one
    injection daily. ElderlyAs with all narcotics a
    reduction in dosage may be advisable in the
    elderly, as appropriat

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