Introduction to Stem Cells and Regenerative Medicine Multipotent Autologous and Allogeneic Therapy - PowerPoint PPT Presentation

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Introduction to Stem Cells and Regenerative Medicine Multipotent Autologous and Allogeneic Therapy

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A stem cell are the building block of humans and are capable of dividing for long periods of time. – PowerPoint PPT presentation

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Title: Introduction to Stem Cells and Regenerative Medicine Multipotent Autologous and Allogeneic Therapy


1
  • An Introduction To Stem Cells
  • Presented By the Stem Cell Center of Thailand

2
An Introducing Stem Cells
3
Overview
This presentation about stem cells is intended as
a tool for educators, scientists, science
communicators. Not all the slides will be useful
for any one occasion. Choose the ones most
suitable for your audience, mix them with your
own slides, or just use the diagrams.
  • Contents
  • Stem cell biology basics For school students
    aged 16, or adult public with little or no
    scientific knowledge
  • Cloning For adult public with little or no
    scientific knowledge initial slides also
    suitable for students aged 16
  • Stem cell biology in more detail For informed
    non-specialist audiences, e.g. clinicians,
    scientists working in fields other than stem cell
    biology and regenerative medicine

Presentation notes Each slide in the Basics and
Cloning sections includes notes that give a
simple, jargon-free explanation of the key
points. The slides in the last section have less
notes and assume some knowledge of stem cell
science. Please visit the site for more details
including stem cell conference schedules,
clinical trials and medical journals. Further
information and resources Have a question or a
comment? Please check out the Interactive Stem
Cell Glossary or Contact us at http//stemcellthai
land.org/contact/
4
Basics of Stem Cell Biology
5
A life story
6
What Is A Stem Cell?
7
What Is A Stem Cell?
8
Why Self-renew AND Differentiate?
1 stem cell
4 specialized cells
1 stem cell
Differentiation - replaces dead or damaged cells
throughout your life
Self renewal - maintains the stem cell pool
9
Where Are Stem Cells Found?
Adult stem cells fetus, baby and throughout life
embryonic stem cells blastocyst - a very early
embryo
10
Types of Stem Cell 1) Embryonic stem cells Esc
11
Embryonic stem (ES) cells Where we find them
12
Embryonic stem (ES) cells What they can do
embryonic stem cells
PLURIPOTENT
13
Embryonic stem (ES) cells Challenges
embryonic stem cells
14
Types of stem cell 2) Tissue or Adult Stem
Cells
15
Adult stem cells Where we find them
skin
muscles
16
Adult stem cells What they can do
blood stem cell
differentiation
found in bone marrow
only specialized types of blood cell red blood
cells, white blood cells, platelets
MULTIPOTENT
17
Other Types of stem cell 3)Induced pluripotent
(iPS) stem cells
18
Induced pluripotent stem cells (iPS cells)
Advantage no need for embryos!
19
Induced pluripotent stem cells (iPS cells)
genetic reprogramming
pluripotent stem cell (iPS)
cell from the body (skin)
20
Stem Cell Glossary/Terms
Potency A measure of how many types of
specialized cell a stem cell can
make Pluripotent Can make all types of
specialized cells in the body
Embryonic stem cells are pluripotent Multipotent
Can make multiple types of specialized cells,
but not all types Tissue stem cells are
multipotent OTHERS Totipotent Stem Cells and
Oligopotent Cell Lines and Unitpotent
21
Cell Cloning
22
Cloning
There are two VERY different types of cloning
23
Reproductive cloning
24
Molecular cloning Principles
25
Molecular cloning Applications
26
Stem Cell Biology in Detail
27
Tissue Stem cell Types And Hierarchies
28
Tissue stem cells Principles of renewing tissues
Stem cell
  • stem cell
  • self renew
  • divide rarely
  • high potency
  • rare

29
Tissue stem cells Haematopoietic stem cells
(HSCs)
HSC
bone marrow
30
Tissue stem cells Neural stem cells (NSCs)
NSC
Brain Injuries
specialized cells
31
Tissue stem cells Adipose stem cells (ASCs)
GSC
Small intestine or Fat
32
Tissue stem cells Mesenchymal stem cells (MSCs)
MSC
bone marrow
33
The Stem Cell Niche
34
Stem cell niches
Niche Microenvironment around stem cells that
provides support and signals regulating
self-renewal and differentiation
stem cell
niche
35
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