About Aromatase Inhibitors Anastrozole, Letrozole & Exemestane at Research Liquids - PowerPoint PPT Presentation

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About Aromatase Inhibitors Anastrozole, Letrozole & Exemestane at Research Liquids

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Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer and ovarian cancer in postmenopausal women. They may also be used off-label to treat or prevent gynaecomastia in men. Aromatase is the enzyme that synthesizes estrogen. As breast and ovarian cancers require estrogen to grow, AIs are taken to either block the production of estrogen or block the action of estrogen on receptors. There are 2 types of aromatase inhibitors (AIs) approved to treat breast cancer: Irreversible steroidal inhibitors Such as exemestane (Aromasin), forms a permanent and deactivating bond with the aromatase enzyme. Non-steroidal inhibitors Such as anastrozole (Arimidex) and letrozole (Femara), inhibit the synthesis of estrogen via reversible competition for the aromatase enzyme. Visit: – PowerPoint PPT presentation

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Title: About Aromatase Inhibitors Anastrozole, Letrozole & Exemestane at Research Liquids


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  • Aromatase Inhibitors

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AboutAromataseInhibitors
  • Aromatase inhibitors (AIs) are a class
    of drugs used in the treatment of breast
    cancer and ovarian cancer in postmenopausal women.
    They may also be used off-label to treat or
    prevent gynaecomastia in men.
  • Aromatase is the enzyme that synthesizes estrogen.
    As breast and ovarian cancers require estrogen
    to grow, AIs are taken to either block the
    production of estrogen or block the action of
    estrogen on receptors.

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Types OfAromataseInhibitors
  • There are 2 types of aromatase inhibitors (AIs)
    approved to treat breast cancer
  • Irreversible steroidal inhibitors
  • Such as exemestane (Aromasin), forms a permanent
    and deactivating bond with the aromatase enzyme.
  • Non-steroidal inhibitors
  • Such as anastrozole (Arimidex) and letrozole (Fema
    ra), inhibit the synthesis of estrogen via
    reversible competition for the aromatase enzyme.

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Product
  • Exemestane

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Exemestane
  • Details
  • Exemestane is a steroidal irreversible CYP19
    (aromatase) inhibitor. Exemestane is structurally
    related to natural androstenedione and acts as a
    false CYP19 enzyme substrate. This effect is also
    known as "suicide inhibition". Exemestane has
    been found to inhibit human placental CYP19. Buy
    Exemestane of high quality only at Research
    Liquids.

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Exemestane
  • Description
  • Liquid Exemestane is an irreversible steroidal
    aromatase inhibitor (IC50 20 nM). Destabilizes
    aromatase and lowers estrogen levels.
  • Targets Aromatase

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Product
  • Anastrozole

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Details Anastrozole belongs to a class of
compounds known as aromatase inhibitors. An
enzyme known as aromatase is responsible for
producing estrogen by converting androgens into
estrogen. Aromatase inhibitors like Anastrozole
prevent aromatase from fulfilling that role by
binding to it and rendering it inactive.
Aromatase inhibitors fall into two categories
reversible (such as letrozole and Anastrozole )
and irreversible irreversible aromatase
inhibitors permanently bind to the circulating
aromatase complex. Buy Anastrozole of high
quality only at Research Liquids.
Exemestane
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  • Description
  • Liquid Anastrozole is a third-generation
    nonsteroidal selective aromatase inhibitor.
  • Targets Aromatase

Exemestane
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Product
  • Letrozole

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Details Letrozole is a potent, reversible
non-steroidal aromatase inhibitor (IC50 11.5
nM). Displays antitumor effects in several animal
models. Suppresses the endogenous
aromatase-induced proliferation of MCF-7
cells. Buy Letrozole of high quality only at
Research Liquids.
Letrozole
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  • Description
  • Liquid Letrozole is a third generation nonsteroida
    l CYP19 aromatase inhibitor.
  • Targets CYP19

Letrozole
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