Infections and cancer the importance of Burkitt lymphoma

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Infections and cancer the importance of Burkitt
lymphoma

• Rob Newton
• Epidemiology Genetics Unit, Department of
  Health Sciences and the Hull York Medical School

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Peyton Rous (1879-1970)
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African Burkitt lymphoma

• First tumour associated with an oncogenic virus
• First tumour successfully treated with
  combination chemotherapy
• Introduced oncology to tumour lysis syndrome
• Classical chromosomal translocations
• Different to Burkitt-type tumours in the west

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UGANDA
Kampala
Entebbe
75 miles
Lake Victoria
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Sir Albert Ruskin Cook 1870-1951
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The first Mengo Hospital 1897
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Mengo Hospital today
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Brief history

• Born Enniskillen, Ireland
• Education engineering then medicine
• 1938 FRCS, Edinburgh
• 1941 Royal Army Medical Corps
• 1943 Served with African troops in Kenya
• 1946-64 Colonial medical service in Uganda,
  mainly Mulago hospital
• 1957 2 children seen with swellings of the jaw

Denis Parsons Burkitt Surgeon geographical
epidemiologist 1911 - 1993
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The British Journal of Surgery, 1958
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More recent history
Professor Michael Anthony Epstein
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Source de-Thé et al, Nature 1978
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The research team
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John L Zeigler Albert Lasker Award for Clinical
Medical Research, 1972 For his outstanding
contribution in increasing the cure rate of
Burkitt's tumor by chemotherapy
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Associations with serological test results for
Epstein-Barr virus and malaria antibodies Uganda

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Prevention of Burkitt lymphoma

• Use of insecticides in the home
• Use of bed nets
• - 80 reduction in risk

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Infections and Human Cancer 1964 EBV
(Burkitts lymphoma) National Cancer Act (1971)
1980 HTLV-1 (Human T-cell leukaemia) 1981
Hepatitis B linked to liver cancer 1983 - HPV-16
(cervical cancer) H. pylori (stomach cancer)
HIV (KS, NHL) 1989 Hepatitis C (liver
cancer) 1994 KSHV/HHV-8 (Kaposis
sarcoma) 2007 Merkel Cell Polyomavirus (Merkel
Cell Carcinoma) (BUT 19th century/cervix
cancer 1905 Goebel bladder cancer due to
bilharzia)
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Helicobacter pylori

• Robin Warren and Barry Marshall

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HPV and cancer of the cervixThe role of
epidemiology
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Professor Harald Zur Hausen
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Conjunctival and cutaneous squamous cell carcinoma
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