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Biocompatibility of Zrbased bulk metallic glasses: effects of composition and roughness

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Title: Biocompatibility of Zrbased bulk metallic glasses: effects of composition and roughness


1
Biocompatibility of Zr-based bulk metallic
glasses effects of composition and roughness
  • Lu Huang a, b, Zheng Cao a, Wei He a, Harry Meyer
    c,
  • Peter K. Liaw a, Tao Zhang b

Department of Materials Science and Engineering,
The University of Tennessee, Knoxville, TN
37996-2200, USA School of Materials Science and
Engineering, Beijing University of Aeronautics
and Astronautics, Beijing 100083,
China Microscopy Group, Metals and Ceramics
Division, Oak Ridge National Laboratory, 1 Bethel
Valley Road, Oak Ridge, TN 37831, USA
2
Outline
  • Motivation
  • Critical issues
  • Experimental methods
  • Results and discussions
  • Conclusions

3
Motivation
Biomedical Applications of BMGs
4
Research Background (Contd)
5
Research Background (Contd)
6
Critical Issues
  • To investigate the corrosion behaviors of
    Zr55Al10Cu30Ni5 and (Zr55Al10Cu30Ni5)99Y1 BMGs in
    a physiologically-relevant environment
  • To preliminarily study the cytotoxicity of
    Zr55Al10Cu30Ni5 and (Zr55Al10Cu30Ni5)99Y1 BMGs
  • To determine the effects of 1 at. Y addition and
    different roughness on the biocompatibility of
    Zr-based BMGs
  • To compare the results of Zr-based BMGs with
    those of standard, crystalline biomaterials

7
Experimental Methods
  • Samples preparation
  • Materials Zr55Al10Cu30Ni5,
  • (Zr55Al10Cu30Ni5)99Y1 (at.)
  • Control Ti-6Al-4V

Arc-melting copper mold casting
8
Experimental Methods (Contd)
  • Electrochemical tests Cyclic-anodic-polarization

Three-electrode cell
Working electrode (WE) the corrosion
sample Reference electrode (RE) saturated
calomel electrode (SCE) Counter electrode (CE)
platinum foil
9
Experimental Methods (Contd)
  • Cytotoxicity tests

Position the sample in the middle of the well
10
Experimental Methods (Contd)
  • Statistical analysis
  • Corrosion data were reported as
  • means standard deviation (STDEV) (n 5)
  • Cytotoxicity data were reported as
  • means standard error of mean (SEM) (n 3)
  • Statistical comparisons were performed using
    Students t-test
  • A P-value less than 0.05 was considered
    statistically significant

11
Results and Discussions
Cyclic-anodic polarization results
12
Results and Discussions (Contd)
Corrosion parameters
Faradays Law CPR 0.327 (Micorr)/mr
Pitting overpotential Epit - Ecorr
CPR (mm/y) - corrosion penetration rate, M
(g/mol) - atomic mass, r (g/cm3) density, m -
metal-ion valence, icorr (mA/m2) corrosion
current density.
describes the resistance to the onset of pitting
Ref. Lu Huang, Dongchun Qiao, Brandice Green et
al. Bio-corrosion study on zirconium- based
bulk metallic glasses, Intermetallics, 2009
13
Results and Discussions (Contd)
XPS Survey
14
Results and Discussions (Contd)
Cell adhesion
Ti-6Al-4V Alloy
(Zr55Al10Cu30Ni5)99Y1 BMG
Zr55Al10Cu30Ni5 BMG
15
Results and Discussions (Contd )
Viability / Proliferation
A
A
AB
AB
B
16
Conclusions
  • Y addition effects
  • beneficial to the in-vitro corrosion resistance
  • neutral to the cytotoxicity properties
  • Surface roughness effects
  • Cell adhesion
  • No significant difference
  • Proliferation
  • No significant difference for Ti alloy and
    (Zr55Al10Ni5Cu30 )99Y1 BMG
  • Rougher surface is better for Zr55Al10Ni5Cu30
    BMG
  • Comparison with standard crystalline biomedical
    alloys
  • a comparable corrosion resistance and
    biocompatibility

17
Acknowledgement
  • This work is financially supported by
  • The National Science Foundation (NSF)
    International Materials Institutes (IMI) Program
    (DMR-0231320)
  • The National Science Foundation Integrative
    Graduate Education and Research Training (IGERT)
    Program
  • The National Science Foundation of China (NSFC)
    (Nos. 50771005 and 50631010)
  • The authors are grateful to Dr. Dunlap for his
    kind help

18
Thanks!Questions or Comments?
19
Results and Discussions
Fundamentals of corrosion
Schematic cyclic-anodic-polarization behaviors of
passive materials
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