Schizophrenia: Examination of rehospitalization rates between antipsychotic therapy and mega vitamin

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Schizophrenia Examination of re-hospitalization
rates between anti-psychotic therapy and mega
vitamin therapy
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Introduction

• 2 mathematical models
• 1st mathematical model describes relationship
  between recurrent hospitalizations of diagnosed
  schizophrenics and antipsychotic drug treatment.
• 2nd mathematical model describes recurrent
  hospitalizations of diagnosed schizophrenics in
  combination with mega-vitamin therapy
  (unconventional, orthomolecular approach).

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Treatment(conventional)

• Antidepressants
• MAOI, SSRI, used to treat the negative symptoms.
• Antipsychotic
• Sedative and neuroleptics, used to treat positive
  symptoms.
• Drugs such as clozapine inhibit dopamine, but can
  decrease white blood cell count a life
  threatening side-effect. These do not help simple
  or catatonic patients.

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Treatment(unconventional)

• Megavitamin Therapy
• Supplements vitamin B 3, 6, 12
• vitamin C, zinc and manganese
• Balanced Diet
• Psychological Therapy
• Weekly meetings to discuss feelings, emotional
  state, and traumatic events
• Family history analysis
• Reduced Stress
• Increases proper enzyme metabolism
• More light and exercise

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How data will be obtained

• Based on a study that came out January 1st 2008
  where 21590 schizophrenics (from157 hospitals
  across the nation representing 30873 total
  hospitalizations) were studied in conjunction
  with anti-psychotic therapy and data collected
  from orthomolecular journals.

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Purpose

• The purpose of this mathematical modeling project
  is to compare re-hospitalization rates for
  schizophrenics using anti-psychotic therapy with
  schizophrenics using mega-vitamin therapy.
• Determine which therapy for schizophrenia has
  lower re-hospitalization rates.

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Anti-Psychotic Therapy

• Collect all data pertaining to diagnosed
  schizophrenics and their hospital visits.
• In a recent study over 21000 schizophrenics were
  analyzed over an 11 month period, representing
  over 30,000 hospitalizations.
• Average length of hospital stay 10 days
• 30 readmitted for related reason with 90 days
  of previous visit.

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Factors affecting hospital stay with
anti-psychotic therapy

• Type of anti-psychotic treatment (short or long
  acting)
• Medication changes
• Dosage changes
• Initial use of short-acting psychotic treatment
  was found to correlate with longer hospital stay.
• The anti-psychotic study

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Two antipsychotic medications examined

• Risperdal
• Clozapine
• Look at which treatment has higher ALOS in
  hospitals, and rehospitalization rates.
• A lot of data comparing these two treatments.
• http//www.ncbi.nlm.nih.gov/pubmed/17891257?doptA
  bstractPlusholdingf1000,f1000m,isrctn

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Orthomolecular Therapy

• Orthomolecular Journals
• Find data for readmission rates from these
  journals.
• Nutritional deficiencies related to higher
  average length of stay in Canadian hospitals.

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Predictions

• Schizophrenics using risperdal and their
  subsequent hospital readmission data.
• Schizophrenics using clozapine and their
  subsequent hospital readmission data
• Schizophrenics using mega-vitamin therapy and
  hospital data.
• Compare and predict best treatment.

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USA Schizophrenia TimelineBase line for insanity
in the USA is 4 cases for every 1000 people
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Genetic risk for development of schizophrenia

• Grandchildren 5 percent
• Uncles aunts 2 percent
• Half siblings 6 percent
• Siblings 8 percent
• Siblings with one schizophrenic parent 17
  percent
• Children 13 percent
• Fraternal twins 18 percent
• Identical twins 48 percent
• Offspring from two schizo. parents 47 percent

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Ideal Treatment

• 1) Treatment facility with high sunshine, high
  calcium and zinc in water
• 2) Genetic Screening
• 3) Allergy Testing (fasting)
• 4) Sugar (per capita comparison)
• 5) Adrenechrome reduction
• 6) Mitigation of biochemical imbalances caused by
  genetic abberations
• 7) Repairing the damage (brain atrophy associated
  with less blood glutathione peroxidase, therefore
  supplement production with nutrients)
• 8) Repair the soul

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Review of Orthomolecular Lit.

• What Really Causes Schizophrenia - Harold D.
  FosterNatural Healing for Schizophrenia - Eva
  EdelmanOrthomolecular Treatment for
  Schizophrenia - Abram HofferOrthomolecular
  Treatment for Schizophrenia A Guide for
  Practitioners - Abram HofferThe Adrenechrome
  Hypothesis and Psychiatry - A. Hoffer and H.
  OsmondA Further Study on the Validity of the
  Hoffer-Osmond Diagnostic Test - Harold Kelm and
  Alan KelmThe Detoxifaction Supplementation
  Therapy - Purificacion L. VerzosaEcologic-Metabol
  ic Profile of Schizophrenia - W. Philpott, K.
  Philpott, E. Bridges, and M. StreamOrthomolecular
  Treatment in Disturbances Involving Brain
  Function - Louis SilvermanJournals of
  Orthomolecular Medicine (JOM)International
  Society of Orthomolecular Medicine (ISOM)Zinc
  and Manganese in the Schizophrenias - Carl
  Pfeiffer and Scott LaMola

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Review of Conventional Lit.

• Comprehensive Textbook of Psychiatry/ IV - Harold
  Kaplan and Benjamin SaddockInfluence of
  medication treatment patterns of resource use for
  patients hospitalized for schizophrenia - D.
  Strutton, BGutierrez, and C. BlanchetteSchizophre
  nia, an Integrated Approach to Research and
  Treatment - M.J. Birchwood, S.E. Hallet, and M.C.
  PrestonSchizophrenia and Psychosis Treatment -
  John GroholSchizophrenia Genesis, The Origins of
  Madness - Irving GottesmanClozapine and the
  Treatment of Schizophrenia - Patricia B.
  HigginsRehospitalization rates of patients with
  schizophrenia discharged on haloperidol,
  risperidone or clozapine - Ana Paula Werneck de
  Castro and Helio Elkis