Title: Current and Emerging Bioengineering Activities and Trends at the NIBIB, NIH ASEE Engineering Researc
1Current and Emerging Bioengineering Activities
and Trends at the NIBIB, NIHASEE Engineering
Research CouncilMarch 1, 2004
- William Heetderks, M.D., Ph.D.
- Associate Director for Science Programs
- National Institute for Biomedical Engineering and
Bioengineering
2Thing that are not changing
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4NIH looks for Excellence as judged by the peer
review processNIH develops long-term
relationships with investigators
5Review Criteria
- Significance Does the study address an important
problem? How will scientific knowledge be
advanced? - Approach Are design and methods well-developed
and appropriate? Are problem areas addressed? - Innovation Are there novel concepts or
approaches? Are the aims original and
innovative? - Investigator Is the investigator appropriately
trained? - Environment Does the scientific environment
contribute to the probability of success? Are
there unique features of the scientific
environment?
6www.nibib.nih.gov
7Who are you going to call?
- Senior program staff at research institutes and
centers - Have good overview of their IC and others with
related programs - For BECON, a list is available at
http//www.becon.nih.gov - For NIBIB the list is available at
www.nibib.nih.gov
8Current NIBIB Portfolio Areas
- Medical devices implant sciences
- Mathematical modeling, simulation analysis
- Magnetic resonance imaging spectroscopy
- Nanotechnology
- Nuclear medicine
- Optical imaging spectroscopy
- Platform technologies
9Current NIBIB Portfolio Areas
- Image processing, displays perception
- Surgical technologies
- Telemedicine
- Tissue engineering
- Ultrasound, photoacoustics thermoacoustics
- X-ray, electron ion beam techniques
- Rehabilitation engineering
10Things that are changing
11NIH Roadmap
- Goal- identify trans-NIH priorities and
opportunities to improve the the nations health - Research areas were identified in a series of
roadmap meetings in 2003 - Roadmap groups, led by institute directors,
developed specific high-priority initiatives on 9
topics in three broad areas leading to NIH
Roadmap Initiatives http//nihroadmap.nih.gov
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13PHS 398 Grant Application
- Specific Aims Section Now States
- List the broad, long-term objectives and what the
specific research proposed in this application is
intended to accomplish, e.g., to . . .
14PHS 398 Grant Application
- test a stated hypothesis,
- create a novel design,
- solve a specific problem, or
- develop new technology
15Peer Review
- Study Sections
- Managed by Scientific Review Administrator (SRA)
- Professional, usually at the Ph.D. level
- Each CSR standing study section has 12 - 24
members - IC review panels are more generally Special
Emphasis Panels (SEPs) - From 3 to over 100 applications are reviewed at
each study section meeting
16Bioengineering Sciences and Technologies IRG BST
- The Bioengineering Sciences and Technologies
BST IRG will review grant applications that
focus on fundamental aspects of bioengineering
and technology development in the following
areas gene and drug delivery systems, imaging
principles for molecules and cells, modeling of
biological systems, bioinformatics and computer
science, statistics and data management,
instrumentation, chips and microarrays,
biosensors, and biomaterials. While biological
context is important in bioengineering, a central
premise in organizing this IRG is the need for
effective review of bioengineering and technology
development in early stages before specific
practical uses are proven.
17Bioengineering Sciences and Technologies IRG BST
- Gene and Drug Delivery Systems GDD
- Microscopic Imaging MI
- Modeling and Analysis of Biological Systems
MABS - Biodata Management and Analysis BDMA
- Instrumentation and Systems Development ISD
- Biomaterials and Biointerfaces BMBI
18Surgical Sciences, Biomedical Imaging, and
Bioengineering IRG SBIB
- The Surgical Sciences, Biomedical Imaging, and
Bioengineering SBIB IRG reviews applications
for research grants that address topics in a
variety of areas at the interface between a
physical science or engineering and biomedical or
clinical research. - Development of molecular probes and contrast
agents development of molecular imaging
techniques and basic, applied, and pre-clinical
aspects of the design and development of medical
imaging systems (including hardware, software and
mathematical methods of image analysis) for
studying organs or whole animals (including
humans). - Application of computational sciences to
knowledge and information in bio and clinical
medicine, healthcare and their integration. - Development of biomedical sensing and
measurement instrumentation diagnostic
instrumentation creating knowledge to enhance
organ system function and recovery innovative
biologics, materials, processes, implants,
devices and informatics approaches to prevent,
diagnose, and treat disease. - Surgery and anesthesiology host response to
sepsis and injury surgical and microsurgical
therapies surgical critical care and emergency
medicine treatment of trauma multi-organ
responses to surgery.
19Surgical Sciences, Biomedical Imaging, and
Bioengineering IRG SBIB
- Biomedical Imaging Technology BMIT
- Medical Imaging MEDI
- Biomedical Computing and Health Informatics
BCHI - Bioengineering, Technology, and Surgical Sciences
BTSS - Surgery, Anesthesiology, and Trauma SAT
- Small Business Biomedical Imaging SBMI
- Small Business Bioengineering, Surgical Sciences
and Technology SBTS - Small Business Biomedical Sensing, Measurement
and Instrumentation SSMI - Small Business Bioelectromagnetics Special
Emphasis Panel
20NIBIB ORGANIZATION
May 2003
21NIBIB Funding
Dollars in Millions
Fiscal Year
NIBIB Established
22NIBIB Grant Awards for FY2003 256M Total
23FY03 Grants
24Exploratory/Developmental Bioengineering Research
Grants (EBRG)
- R21 awards exploratory or developmental
bioengineering research that is not appropriate
for the R01 grant mechanism - Receipt Dates February 1, June 1, October 1
- Award limit - 275k over two years
- PA-03-058
25Bioengineering Research Grants
- R01 awards Apply basic bioengineering
design-directed or hypothesis-driven research to
an important biomedical area. - Aimed at single or small groups of researchers
- Receipt Dates February 1, June 1, October 1
- 152 BRG awards Average award - 300k
- PA-02-011
26Bioengineering Research Partnerships
- R01 awards special review
- Requires a multi-disciplinary research team
applying an integrative, systems approach to
address a biomedical problem - Receipt Dates January 23, 2003 and August 22,
2003 - 104 BRP awards - Average award - 880k
- PAR-03-032
27Biomedical Engineering Summer Internship Program
June 7-August 13, 2004 (BESIP)
- In a partnership of the National Institutes of
Health (NIH), the Foundation for the National
Institutes of Health, and the Whitaker
Foundation, a Biomedical Engineering Summer
Internship Program(BESIP) is being offered at the
NIH. This ten week summer program allows
undergraduate biomedical engineering students to
participate, under the mentorship of world class
scientists in cutting edge biomedical research
projects at NIH. - Selected by a nationwide competition, the twelve
to sixteen interns will have the opportunity to
indicate preferences from a list of available NIH
projects that involve areas of engineering or
physical science expertise. The students will
participate in group meetings, attend planned
lectures and laboratory visits, and be encouraged
to submit posters to the NIH Poster Day where
summer interns from all disciplines present their
projects.
28- BESIP CLASS OF 2002Front Row Brian Howie,
Trang Nguyen, James (Kimo) Pascual, Huyen Luong,
Maria Kahle, Helen Fuller Second Row Dr.
Robert Lutz, BESIP Director, Christine Palmer,
Katie Peters Third Row Theresa Sukal, Biju
Parrekkadan, Allen Joseph, David Brogan, Matt
Keller Back Row Tom Lozito, Darci Phillips,
Brandon Togioka
29Career Development
- Midcareer Investigator Award in Patient-oriented
Research (K24) - Mentored Research Scientist Development Award
(K01) - Independent Scientist Award (K02)
- Mentored Clinical Scientist Development Award
(K08) - Mentored Patient-Oriented Research Career
Development Award (K23) - Mentored Quantitative Research Career Development
Award (K25) - Encourage research-oriented quantitative
scientists and engineers with little - or no experience in biomedicine, bioengineering,
bioimaging, or behavioral - research to gain fundamental knowledge in these
areas and develop relevant - research skills, and to gain experience in
current concepts, advanced methods, - and experimental approaches that will allow them
to conduct basic or clinical - biomedical, behavioral, bioimaging, or
bioengineering research, and to become - independent investigators or play leading roles
in multi-disciplinary research - teams.
30NIBIB Milestones
- Establishment package approved by DHHS in April
2001 Dr. Donna Dean named AD - First budget approved on January 10, 2002
- First RFAs issued February 2002
- First grant made April 2002
- Dr. Roderic Pettigrew arrives as first Director
September 2002 - Futures Workshop December 2002
- First Advisory Council Meeting (NACBIB)
January 2003 - 170 Awards made on 10 RFAs for FY2003 - September
2003 - FY2003 closed with over 700 grant awards made
31NIBIB Summary
- New first award less than two years ago
- Active over 700 awards, over 250M in funding in
FY03 - Accessible Web site contains a wealth of
information for the initiated - People Staff, especially Program Directors are
available to provide advice consultation to
potential investigators or trainees
32Grant Application Review
33Study Section
34NIH Summary
- NIBIB the newest of 26 institutes
- Standard forms, expectations, and review
- NIH wide roadmap activities
- BECON supporting initiatives
- Small Business Innovative Research Grants
- 27B dollar budget