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Current and Emerging Bioengineering Activities and Trends at the NIBIB, NIH ASEE Engineering Researc

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Second Row: Dr. Robert Lutz, BESIP Director, Christine Palmer, Katie Peters ... Back Row: Tom Lozito, Darci Phillips, Brandon Togioka. Career Development ... – PowerPoint PPT presentation

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Title: Current and Emerging Bioengineering Activities and Trends at the NIBIB, NIH ASEE Engineering Researc


1
Current and Emerging Bioengineering Activities
and Trends at the NIBIB, NIHASEE Engineering
Research CouncilMarch 1, 2004
  • William Heetderks, M.D., Ph.D.
  • Associate Director for Science Programs
  • National Institute for Biomedical Engineering and
    Bioengineering

2
Thing that are not changing
3
(No Transcript)
4
NIH looks for Excellence as judged by the peer
review processNIH develops long-term
relationships with investigators
5
Review Criteria
  • Significance Does the study address an important
    problem? How will scientific knowledge be
    advanced?
  • Approach Are design and methods well-developed
    and appropriate? Are problem areas addressed?
  • Innovation Are there novel concepts or
    approaches? Are the aims original and
    innovative?
  • Investigator Is the investigator appropriately
    trained?
  • Environment Does the scientific environment
    contribute to the probability of success? Are
    there unique features of the scientific
    environment?

6
www.nibib.nih.gov
7
Who are you going to call?
  • Senior program staff at research institutes and
    centers
  • Have good overview of their IC and others with
    related programs
  • For BECON, a list is available at
    http//www.becon.nih.gov
  • For NIBIB the list is available at
    www.nibib.nih.gov

8
Current NIBIB Portfolio Areas
  • Medical devices implant sciences
  • Mathematical modeling, simulation analysis
  • Magnetic resonance imaging spectroscopy
  • Nanotechnology
  • Nuclear medicine
  • Optical imaging spectroscopy
  • Platform technologies

9
Current NIBIB Portfolio Areas
  • Image processing, displays perception
  • Surgical technologies
  • Telemedicine
  • Tissue engineering
  • Ultrasound, photoacoustics thermoacoustics
  • X-ray, electron ion beam techniques
  • Rehabilitation engineering

10
Things that are changing
11
NIH Roadmap
  • Goal- identify trans-NIH priorities and
    opportunities to improve the the nations health
  • Research areas were identified in a series of
    roadmap meetings in 2003
  • Roadmap groups, led by institute directors,
    developed specific high-priority initiatives on 9
    topics in three broad areas leading to NIH
    Roadmap Initiatives http//nihroadmap.nih.gov

12
(No Transcript)
13
PHS 398 Grant Application
  • Specific Aims Section Now States
  • List the broad, long-term objectives and what the
    specific research proposed in this application is
    intended to accomplish, e.g., to . . .

14
PHS 398 Grant Application
  • test a stated hypothesis,
  • create a novel design,
  • solve a specific problem, or
  • develop new technology

15
Peer Review
  • Study Sections
  • Managed by Scientific Review Administrator (SRA)
  • Professional, usually at the Ph.D. level
  • Each CSR standing study section has 12 - 24
    members
  • IC review panels are more generally Special
    Emphasis Panels (SEPs)
  • From 3 to over 100 applications are reviewed at
    each study section meeting

16
Bioengineering Sciences and Technologies IRG BST
  • The Bioengineering Sciences and Technologies
    BST IRG will review grant applications that
    focus on fundamental aspects of bioengineering
    and technology development in the following
    areas gene and drug delivery systems, imaging
    principles for molecules and cells, modeling of
    biological systems, bioinformatics and computer
    science, statistics and data management,
    instrumentation, chips and microarrays,
    biosensors, and biomaterials. While biological
    context is important in bioengineering, a central
    premise in organizing this IRG is the need for
    effective review of bioengineering and technology
    development in early stages before specific
    practical uses are proven.

17
Bioengineering Sciences and Technologies IRG BST
  • Gene and Drug Delivery Systems GDD
  • Microscopic Imaging MI
  • Modeling and Analysis of Biological Systems
    MABS
  • Biodata Management and Analysis BDMA
  • Instrumentation and Systems Development ISD
  • Biomaterials and Biointerfaces BMBI

18
Surgical Sciences, Biomedical Imaging, and
Bioengineering IRG SBIB
  • The Surgical Sciences, Biomedical Imaging, and
    Bioengineering SBIB IRG reviews applications
    for research grants that address topics in a
    variety of areas at the interface between a
    physical science or engineering and biomedical or
    clinical research.
  • Development of molecular probes and contrast
    agents development of molecular imaging
    techniques and basic, applied, and pre-clinical
    aspects of the design and development of medical
    imaging systems (including hardware, software and
    mathematical methods of image analysis) for
    studying organs or whole animals (including
    humans).
  • Application of computational sciences to
    knowledge and information in bio and clinical
    medicine, healthcare and their integration.
  • Development of biomedical sensing and
    measurement instrumentation diagnostic
    instrumentation creating knowledge to enhance
    organ system function and recovery innovative
    biologics, materials, processes, implants,
    devices and informatics approaches to prevent,
    diagnose, and treat disease.
  • Surgery and anesthesiology host response to
    sepsis and injury surgical and microsurgical
    therapies surgical critical care and emergency
    medicine treatment of trauma multi-organ
    responses to surgery.

19
Surgical Sciences, Biomedical Imaging, and
Bioengineering IRG SBIB
  • Biomedical Imaging Technology BMIT
  • Medical Imaging MEDI
  • Biomedical Computing and Health Informatics
    BCHI
  • Bioengineering, Technology, and Surgical Sciences
    BTSS
  • Surgery, Anesthesiology, and Trauma SAT
  • Small Business Biomedical Imaging SBMI
  • Small Business Bioengineering, Surgical Sciences
    and Technology SBTS
  • Small Business Biomedical Sensing, Measurement
    and Instrumentation SSMI
  • Small Business Bioelectromagnetics Special
    Emphasis Panel

20
NIBIB ORGANIZATION
May 2003
21
NIBIB Funding
Dollars in Millions
Fiscal Year
NIBIB Established
22
NIBIB Grant Awards for FY2003 256M Total
23
FY03 Grants
24
Exploratory/Developmental Bioengineering Research
Grants (EBRG)
  • R21 awards exploratory or developmental
    bioengineering research that is not appropriate
    for the R01 grant mechanism
  • Receipt Dates February 1, June 1, October 1
  • Award limit - 275k over two years
  • PA-03-058

25
Bioengineering Research Grants
  • R01 awards Apply basic bioengineering
    design-directed or hypothesis-driven research to
    an important biomedical area.
  • Aimed at single or small groups of researchers
  • Receipt Dates February 1, June 1, October 1
  • 152 BRG awards Average award - 300k
  • PA-02-011

26
Bioengineering Research Partnerships
  • R01 awards special review
  • Requires a multi-disciplinary research team
    applying an integrative, systems approach to
    address a biomedical problem
  • Receipt Dates January 23, 2003 and August 22,
    2003
  • 104 BRP awards - Average award - 880k
  • PAR-03-032

27
Biomedical Engineering Summer Internship Program
June 7-August 13, 2004 (BESIP)
  • In a partnership of the National Institutes of
    Health (NIH), the Foundation for the National
    Institutes of Health, and the Whitaker
    Foundation, a Biomedical Engineering Summer
    Internship Program(BESIP) is being offered at the
    NIH. This ten week summer program allows
    undergraduate biomedical engineering students to
    participate, under the mentorship of world class
    scientists in cutting edge biomedical research
    projects at NIH.
  • Selected by a nationwide competition, the twelve
    to sixteen interns will have the opportunity to
    indicate preferences from a list of available NIH
    projects that involve areas of engineering or
    physical science expertise. The students will
    participate in group meetings, attend planned
    lectures and laboratory visits, and be encouraged
    to submit posters to the NIH Poster Day where
    summer interns from all disciplines present their
    projects.

28
  • BESIP CLASS OF 2002Front Row Brian Howie,
    Trang Nguyen, James (Kimo) Pascual, Huyen Luong,
    Maria Kahle, Helen Fuller Second Row Dr.
    Robert Lutz, BESIP Director, Christine Palmer,
    Katie Peters Third Row Theresa Sukal, Biju
    Parrekkadan, Allen Joseph, David Brogan, Matt
    Keller Back Row Tom Lozito, Darci Phillips,
    Brandon Togioka

29
Career Development
  • Midcareer Investigator Award in Patient-oriented
    Research (K24)
  • Mentored Research Scientist Development Award
    (K01)
  • Independent Scientist Award (K02)
  • Mentored Clinical Scientist Development Award
    (K08)
  • Mentored Patient-Oriented Research Career
    Development Award (K23)
  • Mentored Quantitative Research Career Development
    Award (K25)
  • Encourage research-oriented quantitative
    scientists and engineers with little
  • or no experience in biomedicine, bioengineering,
    bioimaging, or behavioral
  • research to gain fundamental knowledge in these
    areas and develop relevant
  • research skills, and to gain experience in
    current concepts, advanced methods,
  • and experimental approaches that will allow them
    to conduct basic or clinical
  • biomedical, behavioral, bioimaging, or
    bioengineering research, and to become
  • independent investigators or play leading roles
    in multi-disciplinary research
  • teams.

30
NIBIB Milestones
  • Establishment package approved by DHHS in April
    2001 Dr. Donna Dean named AD
  • First budget approved on January 10, 2002
  • First RFAs issued February 2002
  • First grant made April 2002
  • Dr. Roderic Pettigrew arrives as first Director
    September 2002
  • Futures Workshop December 2002
  • First Advisory Council Meeting (NACBIB)
    January 2003
  • 170 Awards made on 10 RFAs for FY2003 - September
    2003
  • FY2003 closed with over 700 grant awards made

31
NIBIB Summary
  • New first award less than two years ago
  • Active over 700 awards, over 250M in funding in
    FY03
  • Accessible Web site contains a wealth of
    information for the initiated
  • People Staff, especially Program Directors are
    available to provide advice consultation to
    potential investigators or trainees

32
Grant Application Review
33
Study Section
34
NIH Summary
  • NIBIB the newest of 26 institutes
  • Standard forms, expectations, and review
  • NIH wide roadmap activities
  • BECON supporting initiatives
  • Small Business Innovative Research Grants
  • 27B dollar budget
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