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Black Mamba Dendroaspis polylepis

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Receives its name from the black coloration on the inside of its mouth ... 2.' 30 Apr. 2007 http://www.imdb.com/title/tt0378194/quotes . Webshots. ... – PowerPoint PPT presentation

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Title: Black Mamba Dendroaspis polylepis


1
Black MambaDendroaspis polylepis
  • By
  • Tina Joyner
  • Lauren Lefferts
  • Neda Talebreza

2
Black Mamba
  • Largest venomous snake in Africa
  • Average length of 8.2 ft and a maximum length of
    14 ft
  • Receives its name from the black coloration on
    the inside of its mouth
  • The black mamba is the fastest moving snake in
    the world, capable of moving up 12.5 mph

3
Geographic Distributionof Black Mamba
  • Namibia
  • Botswana
  • Mozambique
  • Zimbabwe

4
Behavior
  • Extremely aggressive nature
  • Will actively attack without provocation
  • Bites multiple times in succession
  • A single bite may inject enough venom to kill
    20-40 grown men
  • Can raise up one-third of its body from the
    ground (to kill you)

5
Venom
  • Black Mamba venom is a cocktail of toxins like
    many other snake venoms
  • On average its bite injects 100-120 mg of venom,
    however it can deliver up to 400 mg
  • LD50 is 0.25-0.32 mg/kg
  • 10 to 15 mg is deadly to a human adult
  • Venom is neurotoxic

6
Venom
  • Calciseptine
  • One of many toxins found in Black Mamba venom
  • Consists of a 60 amino acid polypeptide with
    eight cysteines forming four disulfide bridges.
  • Smooth muscle relaxant
  • Inhibitor of cardiac contractions
  • L-type calcium channel blocker
  • Only natural polypeptide toxin to block this type
    of channel.

7
Venom
  • Calciseptine
  • Blocks spontaneous portal vein contractions
  • Blocks contractions in several smooth muscles
  • Abolishes electrically stimulated left atrial
    contractions in the heart
  • Drastically decreases both action potential
    frequency and amplitude

8
L-type Calcium Channel
  • Found in both excitable and nonexcitable tissue
  • Responsible for normal myocardial and vascular
    smooth muscle contractility
  • Five subunits alpha-1, alpha-2, beta, gamma, and
    delta.
  • Dihydropyridine-based calcium antagonists are
    used as markers for these binding sites.

9
Effects on body
  • Local pain in the bite area
  • Tingling sensation in the extremities
  • Drooping eyelids
  • Tunnel vision
  • Sweating
  • Excessive salivation
  • Lack of muscle control (specifically the mouth
    and tongue).
  • Without treatment death from respiratory failure
    will ensue

10
Pop Culture
  • Hmm, I'm sorry, Budd. That was rude of me, wasn't
    it? Budd, I'd like to introduce my friend, the
    black mamba. Black mamba, this is Budd.
  • "In Africa, the saying goes 'In the bush, an
    elephant can kill you, a leopard can kill you,
    and a black mamba can kill you. But only with the
    mamba is death sure.' Hence its handle, 'Death
    Incarnate.' Pretty cool, huh?" (Kill Bill Vol.
    2)

11
References
  • "Black Mamba." Wikipedia. 30 Apr. 2007
    .
  • De Weille, Jan R., H Schweitz, P. Maes, A Tartar,
    and M. Lazdunski. 1991Calciseptine a Peptde
    Isolated Form of Black Mamba Venom, is a Specific
    Bloker of the L-Type Calcium Channel. Proc. Natl.
    Acad. Sci USA 88 2473-2477.
  • "L-Type Calcium Channel." Medical Dictionary
    Online. 30 Apr. 2007 ctionary.org/LTypeCalciumChannel.asp?qLTypeC
    alciumChannel.
  • "Memorable Quotes for Kill Bill VOl. 2." 30 Apr.
    2007 .
  • Webshots. 30 Apr. 2007 mgres?imgurlhttp//image03.webshots.com/3/3/9/76/
    630976_ph.jpgimgrefurlhttp//pets.webshots.com/p
    hoto
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