Title: Biomedical Science in the Net of the 21st Century: Discovering Emergent Properties of Everyday Life
1Biomedical Science in the Net of the 21st
CenturyDiscovering Emergent Properties of
Everyday Life
Bruce R. Schatz Institute for Genomic Biology
and Department of Medical Information
Science University of Illinois at
Urbana-Champaign schatz_at_uiuc.edu,
www.canis.uiuc.edu
Plenary in Opening Session, 7th Symposium on
Understanding Complex Systems University of
Illinois, May 14, 2007
2The Grand Vision
3Computer Science and Infrastructure
- Transparent Federation across Sources
- Generic Protocols for Global Infrastructure
- Ultimate Goal is cyberspace visions of
- being one with all the worlds knowledge
4THE THIRD WAVE OF NET EVOLUTION
CONCEPTS
OBJECTS
PACKETS
5Conceptual Navigation in BeeSpace
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12CONCEPT SWITCHING
- Concept versus Term
- set of semantically equivalent terms
- Concept switching
- region to region (set to set) match
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16Small Worlds Networks
- Community Structure enables Dynamic Clustering
with Large Vectors
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23THE FOURTH WAVE OF NET EVOLUTION
INTERMIND
FEATURES
CONCEPTS
OBJECTS
PACKETS
24Feature Vectors
- from Concepts to Features
- from Semantics to Pragmatics
Interspace is concept navigation across
repositories Intermind is feature comparison
across individuals
25Category Formation
- Definitional 1 feature, yes or no
- Probabilistic 10 features, best subset
- Prototypical 100 features, inherited
- Situational 1000 features, similarity
26Measuring Population Health
- Quality of Life Questionnaires
- Self-Assessment directly by Patients
- QoL correctly does coarse prediction
- VA Heart Study patient better than surgeon
- Electronic Records for fine prediction
- Paper can support 10s of questions
- Electronic can support 100s of questions
- Adaptive Question Asking
- Each session asks 10s of questions customized to
particular situation
27Sample General Health Questions
28Sample Specific Health Questions
29Health Monitor Session
30Beyond Screening
- Why are Some People Healthy? (R. Evans)
- Major categories are disease, health care,
health function, genetic endowment, physical
environment, social environment, individual
response, behavior, well-being, prosperity. - Healthy People 2010
- 467 objectives in 28 focus areas
- www.health.gov/healthypeople
- Measure Full-Spectrum Health Status
- Detailed QoL in each detailed category
31Categories of Everyday Health
- Physical Mental Social
- crossed with
- Ability Function
- Diet Exercise Input/Output
- Personal Environmental Stress
32Population Management
- Possible to Monitor Whole Populations
- Daily Monitors, Full Spectrum of Features
- Cohort Clusters supplement Diagnoses
- Daily Feature Record for each Individual
- Detailed Databases for whole Population
- Analyze Clusters of Similar Patients
- Cohort Switching drive Treatments
- Manage Expectations with Actual Cases
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34The Structures of Everyday Life
- Bodies (individuals)
- Food and Clothes
- Buildings (groups)
- Houses and Cities
- Transportation (physical interactions)
- Rails (trains) and Roads (cars)
- Communication (logical interactions)
- Phones (talking) and Computers (retrieving)
35Structures of Everyday Life
- Group (via Rituals Festivals)
- Food, Clothes
- Family, Home
- Village (via Art Beauty)
- Healthcare, Government
- Education, Memory
- Nation (via Religion Spirituality)
- Transportation, Communication
- Energy, Banking
36- Becoming One
- with All the
- World's Knowledge
37Realizing Wisdom
- Zen Buddhism
- Beyond Concepts to Reality
- A special transmission outside the
scripturesDepending not on words and
lettersPointing directly to the human mind - Seeing into one's nature, one becomes a Buddha.
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- Zen Koans
- Become one with the koan, achieve Satori
- Is the Rice Field moving or not?
38The Intermind
- First Universal Spiritual Wave
- Wave N, Protocols across Minds
- Universal across Mind Realities
- Religions to model Lifestyles
- Feature Vectors break Boundaries
- Infinite Vector is True Reality
- Call the Limit to Satori