Biomedical Science in the Net of the 21st Century: Discovering Emergent Properties of Everyday Life

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Biomedical Science in the Net of the 21st
CenturyDiscovering Emergent Properties of
Everyday Life
Bruce R. Schatz Institute for Genomic Biology
and Department of Medical Information
Science University of Illinois at
Urbana-Champaign schatz_at_uiuc.edu,
www.canis.uiuc.edu
Plenary in Opening Session, 7th Symposium on
Understanding Complex Systems University of
Illinois, May 14, 2007
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The Grand Vision
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Computer Science and Infrastructure

• Transparent Federation across Sources
• Generic Protocols for Global Infrastructure
• Ultimate Goal is cyberspace visions of
• being one with all the worlds knowledge

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THE THIRD WAVE OF NET EVOLUTION
CONCEPTS
OBJECTS
PACKETS
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Conceptual Navigation in BeeSpace
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CONCEPT SWITCHING

• Concept versus Term
• set of semantically equivalent terms
• Concept switching
• region to region (set to set) match

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Small Worlds Networks

• Community Structure enables Dynamic Clustering
  with Large Vectors

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THE FOURTH WAVE OF NET EVOLUTION
INTERMIND
FEATURES
CONCEPTS
OBJECTS
PACKETS
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Feature Vectors

• from Concepts to Features
• from Semantics to Pragmatics

Interspace is concept navigation across
repositories Intermind is feature comparison
across individuals
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Category Formation

• Definitional 1 feature, yes or no
• Probabilistic 10 features, best subset
• Prototypical 100 features, inherited
• Situational 1000 features, similarity

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Measuring Population Health

• Quality of Life Questionnaires
• Self-Assessment directly by Patients
• QoL correctly does coarse prediction
• VA Heart Study patient better than surgeon
• Electronic Records for fine prediction
• Paper can support 10s of questions
• Electronic can support 100s of questions
• Adaptive Question Asking
• Each session asks 10s of questions customized to
  particular situation

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Sample General Health Questions
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Sample Specific Health Questions

• Heart Condition

• Arthritis Condition

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Health Monitor Session
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Beyond Screening

• Why are Some People Healthy? (R. Evans)
• Major categories are disease, health care,
  health function, genetic endowment, physical
  environment, social environment, individual
  response, behavior, well-being, prosperity.
• Healthy People 2010
• 467 objectives in 28 focus areas
• www.health.gov/healthypeople
• Measure Full-Spectrum Health Status
• Detailed QoL in each detailed category

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Categories of Everyday Health

• Physical Mental Social
• crossed with
• Ability Function
• Diet Exercise Input/Output
• Personal Environmental Stress

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Population Management

• Possible to Monitor Whole Populations
• Daily Monitors, Full Spectrum of Features
• Cohort Clusters supplement Diagnoses
• Daily Feature Record for each Individual
• Detailed Databases for whole Population
• Analyze Clusters of Similar Patients
• Cohort Switching drive Treatments
• Manage Expectations with Actual Cases

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The Structures of Everyday Life

• Bodies (individuals)
• Food and Clothes
• Buildings (groups)
• Houses and Cities
• Transportation (physical interactions)
• Rails (trains) and Roads (cars)
• Communication (logical interactions)
• Phones (talking) and Computers (retrieving)

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Structures of Everyday Life

• Group (via Rituals Festivals)
• Food, Clothes
• Family, Home
• Village (via Art Beauty)
• Healthcare, Government
• Education, Memory
• Nation (via Religion Spirituality)
• Transportation, Communication
• Energy, Banking

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• Becoming One
• with All the
• World's Knowledge

• Bodhidharma by Hakuin

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Realizing Wisdom

• Zen Buddhism
• Beyond Concepts to Reality
• A special transmission outside the
  scripturesDepending not on words and
  lettersPointing directly to the human mind
• Seeing into one's nature, one becomes a Buddha.
• Zen Koans
• Become one with the koan, achieve Satori
• Is the Rice Field moving or not?

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The Intermind

• First Universal Spiritual Wave
• Wave N, Protocols across Minds
• Universal across Mind Realities
• Religions to model Lifestyles
• Feature Vectors break Boundaries
• Infinite Vector is True Reality
• Call the Limit to Satori