Institute for Science and Technology in Medicine

1
Institute for Science and Technology in Medicine
Overview of the Institute Mark Smith, RI
Manager, ISTM 2009
2
ISTM Facilitating Biomedical Research at
Keele

• Brings together bioscientists and clinicians at
  two hospital sites and Keele campus.
• Hospital Sites
• University Hospital of North Staffordshire,
  Hartshill
• RJ AH Orthopaedic Hospital, Oswestry
• NHS clinicians plus Keele and NHS research staff
• Keele Campus
• School of Life Sciences
• School of Medicine
• School of Pharmacy
• School of Computing Mathematics
• School of Chemistry Physics

3
ISTM - Philosophy

• To carry out internationally and nationally
  leading research in targeted areas
• To form a multidisciplinary base for basic and
  applied research and its translation into the
  clinical environment
• To provide a quality environment for
  postgraduate training (MSc,PhD)

4
ISTM - Directors

• Co-director
• Prof Alicia El-Haj
• Clinical Co-director
• Prof Clive Hawkins
• Deputy Director
• Prof Paul Eggleston
• Director of Postgraduate Studies
• Prof Trevor Greenhough

5
ISTM - Current Staff

• 71 full members
• Professors 24
• Readers, Senior Lecturers, Clinical Lecturers 23
• Lecturers 19
• Research Fellows 5
• 12 affiliated members from other Keele RIs
• Key chair appointments of senior clinical/non
  clinical academics to expand capacity
• A large percentage of younger researchers in a
  new Medical School

6
ISTM - Training

• One third of staff are new within last 3-4 years
• NHS clinicians continue to join ISTM
• 35 research assistants and technical staff
• 100 PhD/MD research students, of which 25
  overseas

7
ISTM - Activity Metrics

• Manages around 100 current research grants
• Receives 3.1m / year research grant income
• Applies for around 150 new research grants / year
• Outputs around 280 peer-reviewed papers / year
• RAE2008 90 of staff of international
  quality in UoA 25 General Engineering
• RAE2001 5 - UoA 26 General Engineering
• 5 - UoA 3 Hospital Based Clinical
  Subjects (Cancer Studies)
• 4 - UoA 14 Biological Sciences

8
(No Transcript)
9
ISTM - Enterprise Activities

• Industrial collaborations
• e.g. New BBSRC CASE studentships
• e.g. European projects involving SMEs
• Contract research with UK / European industry
• 3M Healthcare Abbott Laboratories
  AstraZeneca Biogen Bose Corporation -
  Enduratec Bristol Myers Squibb Cellon SA
  ConMed Cordis Endovascular Flexercell
  GlaxoSmithKline GW Pharma Merck Sharp
  Dohme Novartis Oxitec PepTcell
  Pfizer Smith Nephew Surgicraft
  Syngenta Teva Weleda AG Wella AG
  Wyeth Research Zimmer
• Licensing of IP
• Spin off companies from ISTM
• Magnecell Intelligent Orthopaedics Trans
  Spectra

10
ISTM Interdisciplinary Approach
Clinical research
bench to bedside
Bioengineering
Biology
11
ISTM New Research Facilities

• Medical School buildings and biological sciences
  laboratories at Keele campus.
• Guy Hilton Research Centre labs and patient
  research centre at Hartshill campus,
• University Hospital of North Staffs.
• Clinical and laboratory facilities at
• the RJ AH Hospital, Oswestry.

12
ISTM - Scientific Themes

• Cellular Neural Engineering
• Imaging and Diagnostics
• Human Disease and Genomics
• Centre for Applied Entomology and Parasitology

13
Cellular Neural Engineering

• Theme leader Dr David Furness
• Cellular phenomena and cellular
• therapies for clinical applications e.g.
• Autologous treatments, e.g. knee cartilage
• Surgical repair, e.g. biomagnetic cell targeting
• Auditory and visual neuroscience
• ISTM is a European Centre of Excellence
• in Tissue Engineering.

14
Cellular Neural Engineering

• Research Funding

Income Sources
15
Imaging and Diagnostics

• Theme leader Dr Doug Corfield
• Interaction between bioscientists,
• engineers, physicists, chemists and a
• range of clinicians e.g.
• Non-invasive analysis and diagnosis of disease
  using Select Ion Flow Tube Mass Spectroscopy.
• Magnetism and magnetic materials techniques for
  biomedical applications, e.g. in the brain.
• Lung research through cell pathology, molecular
  biology and bioengineering.

16
Imaging and Diagnostics

• Research Funding

17
Human Disease and Genomics

• Theme leader Prof Bill Farrell
• Understanding basic disease mechanismsand
  relating them to disease outcomese.g.
• Molecular epidemiology and tumorigenesis
• Apoptosis (programmed cell death)
• Structural biology of the innate immune response
• Rheumatic and inflammatory diseases
• ISTM has a dedicated Human Genomics facility

18
Human Disease and Genomics

• Research Funding

Funding Sources
19
Centre for Applied Entomology and Parasitology
(CAEP)

• Theme leader Prof Richard Ward
• Principal strengths in molecular approaches
  to control of insect vector-borne
  disease
• Malaria, mosquitoes and man
• Leishmania, sandflies and man
• Chemical ecology of insect communication
• Fish parasitology comparative immunology

CAEP is an internationally recognised centre with
links to N S America, Africa, Asia and Europe.
20
Centre for Applied Entomology and Parasitology
(CAEP)

• Research Funding

Funding Sources
21
Contact

• ISTM Website
• http//www.keele.ac.uk/research/istm/index.html
• Mark Smith
• Tel [phone]
• Fax [phone]
• E-mail pma25_at_keele.ac.uk