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SARC Career Development Program


Physician is 5-10 years post final subspecialty training. Full-time faculty ... Candidate within 5 years of completion of final training and must be physician ... – PowerPoint PPT presentation

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Title: SARC Career Development Program

SARC Career Development Program
Laurence Baker Jennifer Keene
  • CTOS meeting London England
  • November 14, 2008

SARCs Goals
  • Engage expert sarcoma researchers and clinicians
    to improve outcome of patients with sarcoma
  • Collaboration of pediatric,medical, surgical,
    orthopaedic and radiation oncologists,
    pathologists, radiologists, medical geneticists,
    and molecular biologists
  • Progress against sarcomas depends on sustained,
    collegiate effort among these experts

  • Grant from Roche to SARC
  • Awarded October 2007
  • 2.5 million unrestricted grant
  • To promote sarcoma career development

  • How does SARC go about designing their own Career
    Development Award??
  • Recipient / Eligibility characteristics
  • Terms of Award
  • Award Process

SARC Career Development Award Committee
  • Laurence Baker
  • Jean Yves Blay
  • John Crowley
  • Marie Debiec-Rychter
  • Jonathan Fletcher
  • Richard Gorlick
  • Lee Helman
  • Steve Ritland
  • Mark Thornton
  • Matt Van de Rijn
  • Jaap Verweij
  • Jay Wunder

Interviews Young Investigator Awardees
  • More freedom
  • Protected time challenging
  • Changes in mentor
  • Pay off loans

Awards for Comparison
  • American Society of Hematology (ASH)
  • Leukemia Lymphoma (L L)
  • American Cancer Society (ACS)
  • American Society of Clinical Oncology (ASCO)
  • National Institute of Health (NIH)
  • K08
  • K12
  • K22
  • K23

ASCO CDA Criteria
  • Physician
  • 1 years post final subspecialty training
  • Full-time faculty appointment
  • Completed postdoctoral/post-fellowship research
  • Demonstrated ability for independent
    investigator-initiated clinical research
  • Active member of ASCO
  • Expect to spend 50 of time dedicated to Research
  • Must have a mentor from their institution and
    institutional letter of support
  • Applicants with existing career development
    awards (K23, K08, etc.) will not be considered
    for funding

ASCO ACRA in Sarcoma
  • Physician is 5-10 years post final subspecialty
  • Full-time faculty appointment
  • Demonstrated ability for independent
    investigator-initiated clinical research
  • Active member of ASCO
  • Expect to spend 75 effort dedicated to research
  • 450,000 over 3 years
  • Raphael Rousseau MD, PhD
  • Nanoparticle-based targeting Tumor
    neoangiogenesis to improve surgical resection in
  • Scott Schuetze, MD PhD
  • Study of sirolimus combined with cyclophosphamide
    in sarcoma

  • Mentored Clinical Scientist Development Award
  • the gold standard
  • Annually for 5 years
  • 75K per year plus fringe benefits
  • 30K research development expenses
  • 75 full-time professional effort to research
    career development

NIH K08 Awards for Sarcoma Research
  • 2007, Tumor Suppressors in Ewings Sarcoma,
    Stephen L. Lessnick (University of Utah)
  • 2007, Tumor Antigen Presentation in Mice
    Developing Cancer, Kevin F. Staveley-OCarroll
    (Penn State Univ, Hershey Med Ctr)
  • 2007, An Animal Model for Kaposis Sarcoma,
    Christopher H. Parsons (Med Univ of SC)
  • 2007, RAS-Mediated ERBB Signaling in
    Osteosarcoma, Dennis P. Hughes (MDACC)
  • 2007, Secreted WNT Inhibitors in the Biology of
    Osteosarcoma, Bang H. Hoang (U of C Irvine)

  • Paul Calabresi Award is a multi- and
    transdisciplinary institutional training award
    supporting the research career development of
    clinicians in clinical Oncology
  • Awards (renewable) for up to 750,000 annually in
    direct costs or 1,050,000 annually (programs
    combining clinicians and PhDs) to institutions
    for up to five years

Funded K12 Grants
  • Mark R. Albertini, University of Wisconsin
  • Robert C. Bast, Univ of TX, MDACC
  • Irwin D. Bernstein, Fred Hutchinson CRC
  • Bruce A. Chabner, Massachusetts General
  • Ross C. Donehower, Johns Hopkins
  • James S. Economou, U of CA Los Angeles
  • Stephen G. Emerson, Penn
  • Stanton L. Gerson, Case Western Reserve University
  • Kenneth R. Hande, Vanderbilt University
  • Lynn C. Hartmann, Mayo Clinic Rochester
  • Herbert Kim Lyerly, Duke University
  • Robert L. Martuza, Massachusetts General
  • David G. Poplack, Baylor College of Medicine
  • Gary K. Schwartz, MSKCC
  • Kenneth S. Zuckerman, University of S. Florida

  • Mentored Patient-Oriented Research Career
    Development Award
  • Support for up to 5 years of combined didactic
    and mentored research
  • Not renewable
  • 75 effort to research and research career
  • 75K per year for salary and fringe benefits
  • 30K for research development support
  • 8 facilities and administrative costs (formerly
    called indirect costs)

NIH K23 Awards for Sarcoma Research
  • 2007,Mechanism/Activity/Resistance/ Gleevec and
  • Jonathan Trent (MD Anderson)
  • 2007, HSP as a Target for the Treatment of
    Childhood Cancer
  • Rochelle Bagatell (University of Arizona)

SARC Career Development Award
  • Candidate may not be supported by another career
    development award
  • Maximum flexibility in funding
  • Time commitment is important criteria
  • If candidate awarded a research grant during term
    of CDA
  • SARC CDA will continue with new research plan
  • Initial awards begin July 2009
  • Award 100,000/yr for 3 years
  • Candidate within 5 years of completion of final
    training and must be physician
  • Candidates must be from Europe, Canada or United

Institutional Commitment
  • Parent institutional commitment important
  • Required letter from mentor with detail of
    mentoring plan
  • Required letter from chairperson or equivalent
  • role of individual on faculty
  • details regarding protected time
  • department/institutional resources provided
  • space, core support, other

SARC Grant Process
  • Submit 2 page letter and CV
  • Applications review/invite full application
  • Complete application using electronic format
  • Timelines
  • Jan 1, 2009
  • Letter of interest
  • Feb 1, 2009
  • Invited full proposal
  • March 15, 2009
  • Proposal due
  • May 1, 2009
  • Notice of funding
  • July 1, 2009
  • Funding begins

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Jennifer Keene and Julia Baker Keene