Master Track BIOMedical Imaging and Modeling

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Master TrackBIOMedical Imagingand Modeling

• Masters voorlichting
• 27 januari 2004

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Kiezen van afstudeeropdracht

• Leuk en ..
• Vaardigheidsblokken
• Koppeling onderwijs-onderzoek
• EHV LABORATORIUMBEZOEK 4 februari
• Programma op (individuele maat) 5 van de 8
  vakken in divisie, diepgang
• Begin bij de contactpersoon
• Hoe kom je aan de contactpersoon?

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• Methods and techniques from mathematics,
  computer science, physics, electrical engineering
  and medicine are used in the imaging, modelling
  and interpretation of biomedical systems.
• Numerous collaborations with more
• applicationally oriented groups.

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• 2 secties
• Sectie 1 Image analysis and interpretation
• Bart ter Haar Romeny
• Image Analysis
• Bart ter Haar Romeny
• Image Processing in Clinical Applications
• Frans Gerritsen

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• 2 secties
• Sectie 2 Biomodeling Peter Hilbers
• Biosignals and regulation
• Paul van de Bosch, Guid Oeij, Ton
  Wagenmakers
• Neurophysics
• Herman Kingma
• - Biomodeling and Bioinformatics
• Peter Hilbers

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• MAAR veel samenwerking over de grenzen van de
  divisie
• Voorbeelden
• Vital Imaging Dick Slaaf
• Spiermetabolisme Klaas Nicolay
• - Modelling of biochemical molecules Bert
  Meijer

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Biomedical Image Analysis (ter Haar Romeny)

• Answering questions on images,
• and showing the answers

www.bmi2.bmt.tue.nl/image-analysis

• Research areas
• Multi-Scale Image processing
• Functions Library
• Image Processing in Clinical
• Applications

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Multi-Scale Image Processing

• Mathematical models based on the working of our
  human visual system

• Image enhancement
• Image segmentation
• Motion detection
• Texture analysis

Functions Library in Mathematica
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Image Processing in Clinical Applications (Frans
Gerristen)

• Segmentation and Analysis

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Image Processing in Clinical Applications (Frans
Gerristen)

• Visualization

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Image Processing in Clinical Applications(Frans
Gerristen)

• Therapy Simulation

• Computer Aided Diagnosis

Courtesy of Stanford University
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Computer-Aided Diagnosis

• CT Thorax lung noduledetection
• Polyp detectionin the colon ( AZM)

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Auditory fMRI
Auditory cortex
Sound characteristics
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Neurophysics(Kingma)

• Physics of the senses, 4 Research topics
• Vestibular sense motion, balance control
• Auditive sense mechanisms of hearing
• Ophtalmology cornea
• Neurophysiology epileptics

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BioSignals and Regulation - BIOMIM
cardiac
bioregulation
bioregulation
physiology
Biosignals

Biosignals

Regulation
Regulation
biosignals
biosignals
skeletal muscle
physiology
signals and systems
signals and systems
physiology
physiology
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Biosignals

• Jan Bergmans
• Hans Blom
• Pierre Cluitmans
• Erik Korsten
• Guid Oei

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Fetal ECG monitoring
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Bioregulation

• Quantitative physiology
• System biology from an integral perspective
• Understanding regulatory mechanisms
• Influence bioregulation

opening the black box
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Bioregulation

• Paul van den Bosch
• Kenneth Meijer
• Natal van Riel
• Hans Savelberg
• Ger van der Vusse
• Ton Wagenmakers

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System identification and parameter estimation to
analyse changed calcium handling in diseased,
intact heart

• High frequency sampling (200 Hz) of
• Free calcium (using fluorescent dye)
• Left ventricular pressure

Model of calcium transients.
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Spatio-temporal models to understand
physiological mechanisms of uptake and transport
of Fatty Acids in myocardium

• Components
• Phospholipids
• Cholesterol
• Proteins
• Glycocalyx

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New experimental model to quantify insulin
sensitivity of muscle and liver in type 2 diabetes
Supported by Diabetes Fonds Nederland
Traditional methods either cannot generate the
sought answers or are invasive
Main determinants of high blood glucose
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Functional effects of muscle adaptation a
simulation in AnyBody

• Adaptive muscle models
• Multi-body modeling
• Simulation of therapeutic interventions and
  training protocols

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Biomodelling and Informatics(Hilbers) 6 research
topics
Neural networks, gene expression and
clusteringsalgoritmes
Heart simulations
Cell, metabolic pathways
Bone simulations
Biomembranes
Genetic algorithms
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Lipids

• Biomembrane consists mainly of (phospho)lipids

stearic acid
dipalmitoylphosphatidylcholine (DPPC)
1-stearoyl-2-oleoylphosphatidylcholine (SOPC)
apolar hydrophobic
polar hydrophilic
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Vesicle formation
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Vital Imaging (Slaaf, van Zandvoort)

• Location Vital Imaging Unit CARIM / BME,
• dept of Biophysics,Maastricht
• Vital imaging applied to vascular and cellular
  research atherosclerosis
• EquipmentTwo-photon excitation (Lifetime)
  Scanning Microscopy
• Intercellular communication of blood cells and
  vessel wall in vivo synchronization of images
  with heart rate.
• (De) differentiation and apoptosis in the
  cardiovascular system
• Tissue characterization (3D) of plaques in vivo
• Technical developments

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