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Nanomedicine and Nanobiology Research and CBET Nanomedicine Workshop August 27, 2007

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Over the next 10 years, the Federal agencies impacted ... Bob Jaeger. Biomedical. Engineering. Semahat Demir. Biophotonics, Imaging & Sensing for Healthcare ... – PowerPoint PPT presentation

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Title: Nanomedicine and Nanobiology Research and CBET Nanomedicine Workshop August 27, 2007


1
Nanomedicine and Nanobiology Research and CBET
Nanomedicine WorkshopAugust 27, 2007
Judy Raper Division Director, Chemical,
Bioengineering, Environmental Transport Systems
2
OUTLINE
  • NSF, ENG and External Forces
  • CBET Organization
  • Budget and Trends
  • Nanomedicine and Nanobiology Research
  • Funding Opportunities
  • Questions

3
NSF, ENG EXTERNAL FORCES
4
National Research Funding
5
NSF Twenty Year Budget by Accountin Millions of
Current Dollars
6
American Competitiveness Initiative
  • The centerpiece of American Competitiveness
    Initiative (ACI) is to double the federal
    investment in key agencies that support basic
    research in physical sciences and engineering.
  • Over the next 10 years, the Federal agencies
    impacted are NSF, DOE Science, and NIST.
  • ACI includes three broad components
  • Research in physical sciences and engineering
    (including 12 specific goals with 7 related to
    NSF)
  • Research and Development tax incentives
  • Education and workforce

7
American Competitiveness InitiativeFY 2007 FY
2016
Source OSTP, Feb. 2006
8
CBET Organization
9
CBET Vision and Mission
  • VISION
  • CBET will be a global leader in identifying and
    enabling the most innovative research and
    education at the frontiers of engineering
    inspiring the integration of physical,
    mathematical and/or life sciences with
    engineering and cultivating a vibrant, diverse
    community in key, emerging and core areas
    benefiting society.
  • MISSION
  • CBET will promote and support transformative
    research and education in engineering areas based
    on the physical, life and/or mathematical
    sciences advance scientific and engineering
    knowledge and develop a diverse, globally
    engaged workforce enhancing the economy of the
    United States.

10
Chemical, Bioengineering, Environmental, and
Transport Systems
Division Director Judy Raper
Deputy Division Director Bob Wellek
Senior Advisor Marshall Lih
Chemical, Biochemical, and Biotechnology
Systems
Biomedical Engineering and Engineering Healthcare
Transport and Thermal Fluids
Environmental Engineering and Sustainability
Process and Reaction Engineering Maria Burka
Thermal Transport Processes Pat Phelan
Research to Aid Persons With Disabilities Bob
Jaeger
Environmental Engineering Marshall Lih
Interfacial Processes And Thermodynamics Bob
Wellek
Environmental Technology Cindy Ekstein
Catalysis and Biocatalysis John Regalbuto
Biomedical Engineering Semahat Demir
Particulate and Multiphase Processes Marc Ingber
Energy for Sustainability Trung Van Nguyen
Biophotonics, Imaging Sensing for
Healthcare Leon Esterowitz
Biotechnology, Biochemical Biomass Eng Fred
Heineken
Fluid Dynamics Bill Schultz
Environmental Sustainability Bruce Hamilton
Chemical and Biological Separations Rose Wesson
Combustion, Fire, and Plasma Systems Phil
Westmoreland
11
Budget and Trends
12
Engineering FY 2008 Budget RequestDollars in
Millions
13
ENG and NSF Funding RatesResearch Grants
ENG Proposals and Awards
Funding Rate Percent
14
CBET Success Rates
All actions
Unsolicited proposals
15
CBET Research ThemesFY 2008
16
CBET Research Thematic Areas
  • Energy, Water and Sustainability
  • closely aligns with the ACI goals of hydrogen and
    solar energy, and research critical to
    alternative energy.
  • Nanoscience and Engineering
  • encourage utilization of research results in
    active nanosystems and devices
  • Systems and Multi-scale Approaches
  • overcoming barriers to quantum information
    processing
  • Integration of Life Sciences in Engineering
    Research
  • Gain advantages of Genomic revolution by
    application of engineering way of thinking

Freeman, Texas
Structure of Virus used for Cancer Therapy Young,
Montana State University
VLP (Virus-Like Particle) with attached vaccine
activators produced by the cell-free
process Swartz, Stanford
Des Jardin,
17
Exploitation of Self-Organization in Virus-like
Particles (VLPs)
Biotechnology, Biochemical and Biomass
Engineering (BBB)
B. Dragnea Indiana University
VLP Assembly Mechanism
Electrostatic interaction leads to the formation
of disordered protein-silver complexes
Symmetric protein shells (blue) assembled around
functionalized metallic cores (yellow) provide
for crystallization of 3D structures
  • Protein-protein interactions lead to the
    formation of a regular capsid (protein shell of a
    virus)

18
Biomedical Engineering (BME)
CAREER Colloidal micelles as multifunctional
vaccines
  • Chemoattracting microspheres
  • Chemoattractants released from hydrogel
    carrier microspheres draw immune cells
    (dendritic cells) to nanoparticles for delivery
    of multiple drug signals
  • Nanoparticles containing drug are sequestered
    inside carrier microsphere until phagocytosed by
    attracted dendritic cell

Darrell Irvine, MIT
Darrell J. Irvine, MIT
19

ARTIFICIAL RETINA SYSTEM
Mark Humayan - USC
  • Array of tiny electrodes attached to inner
    surface of retina
  • Currently uses an external camera
  • Miniature intraocular camera fits within lens sac
  • Allows natural movement of the eye to scan the
    environment

Image of B'Quest crew on dock May-Newman, San
Diego State University
20
Chemical, Biochemical and Biotechnology Systems
A Synthetic Delivery Vehicle for Gene Transfer
- hitchhike gene delivery nanoparticles
onto motor protein complexes - convert chemical
energy to mechanical work - carry nanoparticle
cargo toward cell nuclei

Suzie Pun, U. of Washington
  • Bloodless Biosensing
  • with Carbon Nanotubes- implantable capillary
    devices
  • - filled with carbon nanotubes
  • monitor glucose levels
  • without drawing blood
  • for diabetes and other biosensors

Michael Strano, UIUC
21
FUNDING OPPORTUNITIES
22
Opportunities for Engineering at NSF
  • Disciplinary Research Programs
  • Investigator initiated awards (unsolicited)
  • February 1 March 1
  • August 15 September 15
  • CAREER awards
  • July 18
  • SGER awards
  • Supplements
  • Workshops, Conferences
  • Engineering Education and Centers (EEC)
  • Engineering Research Centers (ERC)
  • Research Experiences for Undergraduates (REU)
    Sites
  • Research Experiences for Teachers (RET) Sites
  • Unsolicited Education awards
  • Industrial Innovation and Partnerships (IIP)
  • Partnership for Innovation
  • Industry/University Cooperative Research Centers
  • SBIR/STTR Programs
  • GOALI Awards

23
Opportunities for Engineering at NSF (contd)
  • Office of Integrative Affairs (IA)
  • Science and Technology Centers (STC)
  • Directorate of Computer Information Science and
    Engineering (CISE)
  • Division of Experimental Integrative Affairs
  • Combined Research Curriculum Development
    Educational Innovation Program (CRCD)
  • Directorate of Education and Human Resources
    (EHR)
  • Division of Undergraduate Education (DUE)
  • Course, Curriculum, and Laboratory Improvement
    (CCLI)
  • Division of Graduate Education (DGE)
  • Integrative Graduate Education and Research
    Training (IGERT)

24
Cyber-Enabled Discovery Innovation (CDI)
  • Broaden the Nations capability for
    innovation by developing a new generation of
    computationally based discovery concepts and
    tools to deal with complex, data-rich, and
    interacting systems.
  • ENG broadly supports research in advanced
    cyber-enabled engineering throughout all its
    divisions.
  • CDI investments areas include
  • Complex interactions
  • Computational experimentation
  • Knowledge extraction
  • Virtual environments
  • Education in computational discovery

25
CAREER
The Faculty Early Career Development (CAREER)
Program a Foundation-wide activity that offers
the NSFs most prestigious awards for new faculty
members. Recognizes and supports the early
career-development activities of those
teacher-scholars who are most likely to become
the academic leaders of the 21st
century. Awardees selected on the basis of
creative, career-development plans that integrate
research and education. Full Proposal Deadline
Date July 17/18/19, 2008
26
Grant Opportunities for Academic Liaison with
Industry (GOALI)
  • Improve the nations capacity for intellectual
    and economic growth by serving as a catalyst for
    university and industry partnerships
  • Effective mechanism for transfer of knowledge
    between academe and industry
  • Promotes fundamental research topics not
    undertaken by industry
  • Supports industry-university educational programs
  • Aims to synergize industry-university
    partnerships by enabling linkages
  • Interdisciplinary university-industry
    collaborative projects (up to 3 years)
  • Faculty, postdoctoral fellows and students in
    industry (up to 1 year)
  • Industry engineers and scientists in academe (up
    to 1 year)
  • Supported by all NSF Directorates

27
Small Grants for Exploratory Research (SGER)
  • High-risk research in the fields of science,
    engineering and education
  • Preliminary work on untested and novel ideas
  • Ventures into emerging research areas
  • Application of new expertise or new approaches to
    research topics
  • Quick-response research on unanticipated events
  • Efforts to catalyze rapid and innovative advances
  • submit to individual programs only after
    discussion with Program Manager
  • two-to-five pages the maximum award amount is
    200,000 for 2 year
  • 20-50k much more common PD is limited in total
    amount he/she can award as SGERs

28
Emerging Frontiers in Research and Innovation
(EFRI)
  • 25 million each year
  • Topics change each year
  • Pre-proposal required
  • PI plus two co-PIs from at least three
    disciplines
  • 500,000/year for 4 years
  • FY 2008 Topics
  • Resilient and Sustainable Infrastructure
  • Design, renew, expand, monitor, and control
    critical interdependent infrastructures to be
    both resilient and sustainable
  • Cognitive Optimization and Prediction through
    Reverse Engineering
  • Understanding subsymbolic intelligence can lead
    to development of new designs and algorithms for
    optimal decision making and prediction in
    engineered systems

29
COGNITIVE OPTIMIZATION AND PREDICTION FROM
NEURAL SYSTEMS TO NEUROTECHNOLOGY (COPN)
  • to understand how massively parallel circuits in
    brains and the associated system identification
    circuits address complex tasks in adaptive
    optimal decision-making and prediction.
  • to develop cognitive engineered designs or
    algorithms for optimal dynamic decision-making
    and/or prediction.

30
Important Information (NSF 07-579)
  • Proposal Information
  • Team Proposals Only
  • 3 or more PIs
  • 3 or more disciplines
  • Award size will depend on the type of research
    program proposed
  • Up to 4 years in duration
  • Up to 500K/year (direct and indirect cost)
  • FY08 Dates
  • Sep 5, 2007 Information Webcast
  • Sep 25, 2007 Letters of Intent Due (required)
  • Oct 26, 2007 Preliminary Proposals Deadline
  • Apr 30, 2008 Full Proposals Deadline
  • (by invitation)

www.nsf.gov/eng/efri
31
Thank YouQuestions
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