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Aquaculture DrugsUpdate

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RozSchnick_at_Centurytel.net. http://ag.ansc.purdue.edu/aquanic/jsa/aquadrugs/index.htm *Presented at the National Association of State Aquaculture Coordinators, ... – PowerPoint PPT presentation

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Title: Aquaculture DrugsUpdate


1
Aquaculture DrugsUpdate
  • Rosalie (Roz) Schnick
  • Michigan State University
  • RozSchnick_at_Centurytel.net
  • http//ag.ansc.purdue.edu/aquanic/jsa/aquadrugs/in
    dex.htm
  • Presented at the National Association of State
    Aquaculture Coordinators, Louisville, Kentucky,
    June 2-5, 2004

2
Major Initiative Nearing Final Completion
  • Federal-State Aquaculture Drug Approval
    Partnership Project (IAFWA Project)
  • Main partners
  • Aquatic Animal Drug Approval Partnership Program
    (AADAP)
  • Upper Midwest Environmental Sciences Center
    (UMESC)
  • Harry K. Dupree Stuttgart National Aquaculture
    Research Center (SNARC)
  • Eight years, formal portion ended September 2002
  • 12 million
  • 9 drugs (marked in turquoise)

3
IAFWA Project Submissions Acceptances (9/03
3/04)
4
IAFWA Project Submissions Acceptances (9/03
3/04)
5
STATUS OF EFFORTS TOWARD APPROVALSAQUACULTURE
THERAPEUTANTS
6
Completed or Nearing Completion Oral
Antibacterials
  • Erythromycin (BPA, NRSP-7, University of Idaho)
  • Bacterial kidney diseasesalmon
  • Florfenicol (was IAFWA Project, MCGP, sponsor)
  • Furunculosis columnaris diseasefreshwater-reared
    salmonids (AADAP, UMESC)
  • Coldwater diseasefreshwater-reared salmonids
    (AADAP, UMESC)
  • Enteric septicemiacatfish (UMESC)
  • Systemic columnaris diseasefreshwater-reared
    salmonids catfish (AADAP UMESC)

7
Completed or Nearing Completion Oral
Antibacterials (continued)
  • Oxytetracycline (oral)approvalsvarious
    diseasescatfish, salmonids, lobsters
  • Coldwater diseaseall freshwater-reared salmonids
    (AADAP, UMESC)
  • Systemic columnaris diseasesteelhead trout
    (AADAP, UMESC)
  • Romet-30approvalsvarious diseasescatfish
    salmonids
  • Romet-TCimproved palatability for top
    coatingaccepted November 2003
  • Sulfamerazineapproved for furunculosissalmonids
    (sponsor not currently distributing product)

8
Work Underway Oral Antibacterials (continued)
  • Amoxicillin (sponsor, Kent SeaTech, NRSP-7,
    SNARC)
  • Streptococcushybrid striped bass tilapia (work
    underway)
  • Oxytetracycline (oral)approvals for catfish,
    salmonids, and lobsters
  • Systemic bacterial diseasesflounder and tilapia
    (NRSP-7)
  • Streptococcustilapia (SNARC)

9
Nearing CompletionExternal antibacterials
  • Chloramine-T (IAFWA Project and sponsor)
  • Bacterial gill diseaseall freshwater-reared
    salmonids (AADAP, UMESC)
  • External columnaris diseasewalleye (UMESC)

10
Nearing CompletionExternal antibacterials
(continued)
  • Hydrogen peroxide (IAFWA Project)
  • Bacterial gill diseaseall freshwater-reared
    salmonids (UMESC)
  • External columnaris diseaseall coolwater fish
    channel catfish (UMESC)
  • Oxytetracycline immersion (IAFWA Project MCGP)
  • Bacterial gill diseasecoolwater warmwater fish
    (UMESC)
  • External columnaris diseasecoolwater warmwater
    fish (UMESC)
  • Systemic columnaris diseasecoolwater warmwater
    fish (UMESC)

11
Work Underway or PossibilityExternal
antibacterials (continued)
  • Copper sulfate (IAFWA Project)
  • Possibility for development (SNARC)
  • Potassium permanganate (IAFWA Project)
  • Possibility for development (SNARC)
  • Pyceze (sponsor)
  • Early development stage

12
Completed or Nearing CompletionFungicides
(control saprolegniasis)
  • Formalinsalmon, trout, esocid eggs
  • Approval extended (IAFWA Project, UMESC)all fish
    eggs 6/18/98
  • Almost completeall fish (UMESC)
  • Hydrogen peroxide (IAFWA Project)
  • Almost completeall fish eggs (UMESC)
  • Almost completeall fish (UMESC)

13
Work UnderwayFungicides (control saprolegniasis)
(continued)
  • Copper sulfate (IAFWA Project sponsor)
  • Work underway (SNARC)
  • Potassium permanganate (IAFWA Project)
  • Possibility for development (SNARC)
  • Pyceze (sponsor)
  • Work underway

14
Completed or Nearing CompletionExternal
parasiticides
  • Copper sulfate (IAFWA Project and sponsor)
  • Ichthyophthiriuschannel catfish in earthen
    ponds (SNARC)
  • FormalinApprovals for certain fish penaeid
    shrimpexternal protozoans
  • Approval extended (NRSP-7, IAFWA Project,
    UMESC)all fishexternal protozoans monogenetic
    trematodes 6/18/98
  • Hydrogen peroxide (IAFWA Project)
  • External protozoanssalmonids (UMESC)
  • Sea lice controls
  • SliceSponsor actively pursuing claim

15
Work UnderwayExternal parasiticides (continued)
  • Potassium permanganate (IAFWA Project)
  • Ichthyophthiriuschannel catfish in earthen
    ponds (SNARC)
  • Pyceze (sponsor)
  • Early development stage

16
Work UnderwayInternal Parasiticides
  • Myxozoan controls
  • Fumagillin
  • Whirling diseasetrout (way underway by FWS,
    others)
  • Proliferative gill diseasecatfish (some work by
    Mississippi State University)
  • Digenetic trematode or cestode controls
  • Praziquantel
  • Bolbophorus confusus in catfish (under
    consideration by sponsor)

17
STATUS OF EFFORTS TOWARD APPROVALSOTHER
AQUACULTURE DRUGS
18
Completed or Work UnderwayZero withdrawal
Anesthetics
  • AQUI-S (IAFWA Project and sponsor)major effort
    underway by both entities
  • All freshwater-reared fish (AADAP UMESC)
  • Saltwater salmonids (sponsor IAFWA Project)
  • MS-222
  • Approvedseveral fish species but with 21-day
    withdrawal time

19
Who Needs Zero Withdrawal Anesthetic?
  • All private fish shellfish aquaculture
    industries
  • All federal state agencies involved in
  • Fish shellfish culture
  • Commercial recreational fisheries
  • Fisheries stock restoration
  • Threatened endangered aquatic species

20
Completed or Work UnderwaySpawning aids
  • Human chorionic gonadotropin (many partners)
  • Approvedall fish 9/7/99
  • Crude carp pituitary (NRSP-7)
  • Almost complete but no possibility of product
    chemistry, so LRP?
  • Ovaplant Ovaprim (sponsor)
  • Work underway
  • ReproBoost (sponsor)
  • Work underway

21
Nearing CompletionGender Manipulation Aids
  • 17 alpha-methyltestosterone (sponsor Auburn
    University)tilapia other species
  • Contract let for product chemistry data
  • Contract let for environmental safety data
  • Contract to be let for target animal
    safetytilapia

22
Completed or Work UnderwayChemical Marking Aids
  • Calcein (have sponsor)work underway
  • Oxytetracycline immersion (NRSP-7, various
    partners including IAFWA Project)
  • Approvedall fish 12/24/03
  • Strontium chloride (have sponsor)work underway
    through NRSP-7

23
FUTURE PLANS
24
Future Plans
  • Develop data on all drugs in progress for initial
    or supplemental NADAs complete goals of the
    IAFWA Project
  • Seek additional sponsors for additional drugs to
    gain initial or supplemental NADAs
  • Seek additional funding sources for aquaculture
    drug approval research
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