BENECOL and CAMELINA Double benefit for heart Anu Hopia, PhD Raisio Benecol Ltd' Functional Foodnet

1
BENECOL and CAMELINA Double benefit for
heartAnu Hopia, PhDRaisio Benecol
Ltd.Functional Foodnet MeetingLiverpoolSeptembe
r 2006
2
BENECOL MAKES CHOLESTEROL REDUCTION EASY

• Reducing cholesterol helps prevent coronary heart
  disease. The active ingredient in Benecol
  products is proven to reduce serum cholesterol.
• This innovative ingredient, plant stanol ester
  was introduced in 1995 and is available only from
  Raisio Benecol. Today, Benecol branded products
  are sold to millions of consumers in more than 20
  countries worldwide.

3
BENECOL MAKES CHOLESTEROL REDUCTION EASY

• Benecol is offered in a range of foods, drinks
  and supplements that meet consumers needs for
  healthy nutrition, convenience and great-tasting
  products. These products are widely recommended
  by health professionals as part of a healthy diet
  to reduce harmful cholesterol and thus lower the
  risk of heart disease.

4
HOW BENECOL GOES TO MARKET

• RAISIO BENECOL
• Benecol ingredient is supplied and the brand is
  licensed by Raisio Benecol to food companies who
  use it to increase the health benefits of their
  products.
• BENECOL PARTNERS
• Food and beverage companies who partner with
  Raisio have made the strategic decision to
  participate in the functional food market. They
  bring these healthy innovations to consumers in
  their countries and cultures.
• CONSUMERS
• Millions of consumers are turning to a wide range
  of Benecol products as a healthy, easy way to
  reduce cholesterol and manage their wellbeing.

5
STRONG SCIENCE

• BENECOL IS CLINICALLY PROVEN TO BE EFFECTIVE
• Benecol works to lower cholesterol by inhibiting
  its absorption by the digestive system.
• More than 40 clinical trials have proven the
  cholesterol-lowering effect of Benecol.
• The daily dose of stanol in Benecol products is 2
  g ( 3,4g stanol ester)

6
STRONG SCIENCE

• BENECOL IS CLINICALLY PROVEN TO BE EFFECTIVE
• The beneficial effects of Benecol are sustained
  in long-term use.
• Use of Benecol adds to the positive effects of
  other dietary strategies or drug therapeutics
  that reduce harmful cholesterol.
• Benecol products are convenient to adopt in
  ones diet.

7
STRONG HEART HEALTH

• It is estimated that a drop of 10 in the total
  serum cholesterol level would lower the risk of
  coronary heart disease (CHD) by 50 in
  40-year-old men, 40 in 50-year-old men and 30
  in 60-year-old men.
• Law MR, Wald NJ., Thompson SG. BMJ
  1994308367-372.

8
STRONG HEART HEALTH

• Benecol maintains its efficacy in long-term use,
  when the product is consumed on a daily basis
  with meals.
• In a 12-month trial, LDL cholesterol was reduced
  by about 14 .
• Miettinen TA, Puska P, Gylling H, Vanhanen H,
  Vartiainen E. N Engl J Med 19953331308-12.

9
ACTIVE INGREDIENT

• All Benecol branded products contain plant
  stanol ester as their active ingredient. Small
  amounts of plant stanols occur naturally in corn,
  wheat, rye and other plants.
• Combining stanols with vegetable oil extracts
  creates plant stanol ester, which is an ideal
  ingredient in various food products. Plant stanol
  ester is produced by a patented process utilizing
  plant stanols and vegetable oil fatty acids.

Sitostanol
Fatty acid
Benecol, plant stanol ester
10
ACTIVE INGREDIENT

• MOLECULAR STRUCTURES
• Plant stanols are a special refined form of plant
  sterols with improved technical and physiological
  functionality. Small differences in the molecular
  structure creates the difference between
  cholesterol, plant sterols and plant stanols.

11
Origins and Fates of Intestinal Cholesterol
Excretion (50)
Benecol reduces effectively the absorption of
both dietary and biliary cholesterol
Re-absorption (50)
Intestinal Cholesterol
Biliary Cholesterol (600-1000 MG/Day)
Source Grundy SM, Cholesterol and
Altherosclerosis, 1989
Dietary Cholesterol (250-500 MG/Day)
12
PARTNERS AND MARKETS
13
PARTNERS AND MARKETS
14
PARTNERS AND MARKETS
BENECOL PRODUCTS WORLDWIDE
Argentina Spread Belgium Spread, Cream cheese,
Yogurt, Yogurt drink Chile Yogurt, Milk
drink Estonia Spread Finland Spread, Pasta,
Yogurt, Buttermilk, Yogurt drink, Milk
drink, Capsules France Spread Malta Spread,
pasta, yogurt drink Germany Yogurt
drink Greece Spread Iceland Yogurt
drink Ireland Spread, Cream cheese, Yogurt,
Yogurt drink
Italy Yogurt drink Luxembourg Spread, Cream
cheese, Yogurt, Yogurt drink Poland Spread,
Yogurt drink Portugal Yogurt drink Spain Yogurt
drink, Milk drink, Yogurt, Spread
Sweden Spread, Yogurt drink Switzerland Yogurt
drink Turkey Yogurt, Yogurt drink, Spread,
UAE Milk drink UK Spread, Cream cheese,
Yogurt, Yogurt drink, Orange
juice USA Spread
15
Benecol is a forerunner
1995, Finland
2001, Spain
2006, England
16
New Benecol - Camelina
17
Omega-3 ? Camelina
18
Camelina oil plant

• Camelina Sativa (eng. falseflax, linseed dodder,
  or gold-of-pleasure ) is an ancient oilseed crop,
  which has been cultivated in Europe during the
  Iron and Bronze Ages
• Originating from Mediterranean region and Middle-
  Asia
• Camelina Sativa raised interest again at the
  1980s, because of its high content of omega-3
  fatty acids
• Canada, Minnesota, Finland, Poland, Russia

19
Omega-3 fatty acids
20
Good fats and bad fats
21
N-3 series alphalinolenic acid ? omega-3 fatty
acid
Omega-carbon
Acid
Methyl
22
Essential fat

• Alpha-linolenic acid (omega-3) together with
  linolenic acid (omega-6) are essential fatty
  acids for the body that must be obtained in the
  diet
• Essential fatty acids are needed in normal growth
  and development (energy, precursor of
  hormone-like compounds, i.e. eicosanoids) and the
  regulation of the body function
• Brain and the nervous system
• Sight
• Skin
• Alpha-linolenic acid is the vegetable origin
  omega-3 fatty acid
• Omega-3 fatty acids have in addition especially
  heart health promoting effects

23
Omega-3 heart health
24
The Nurses Health StudyHigher intake of
alpha-linolenic acid is protective against fatal
ischemic heart disease (45 lower risk)

• Multivariate relative risk of fatal ischemic
  heart disease by quintiles of alpha-linolenic
  acid intake and vitamin E supplement use in
  women.
• ?The more the women ate omega-3 fatty acid the
  lower the fatal heart disease risk
• Ref. Hu FB, Meir JS, Manson JE, et al Dietary
  intake of a-linolenic acid and risk of fatal
  ischemic heart disease among women. Am J Clin
  Nutr. 1999 69 890-897

25
The Lyon Diet Heart StudyGroup who consumed a
Mediterranean-type diet had a significant lower
risk (-72) of cardiac death and non-fatal
myocardial infarction as compared with controls

• Cumulative survival without nonfatal infarction,
  without major secondary end points, and without
  minor secondary end points
• ? Addition of omega-3 fatty acids in the diet
  made the traditional Mediterranean diet even more
  heart healthy
• Ref. de Lorgeril M, Salen P, Martin JL, et al.
  Mediterranean diet, traditional risk factors, and
  the rate of cardiovascular complications after
  myocardial infarction final report of the Lyon
  Diet Heart Study. Circulation. 1999 16
  99(6)779-85

26
Alpha-linolenic acid (ALA)- Intake and
recommendations

• In Finland the intake of alpha-linolenic acid was
  2,0g/day in men and 1,4g/day in women
  respectively (Finravinto 2002), in the USA
  1,4g/day
• Recommendations
• Nordic Nutrition Recommendations (2004) 1 of
  energy from ALA
• WHO/FAO (2002) 1-2 of energy from n-3 fatty
  acids
• RDA (2002) 0,6-1,2 of energy from ALA
• EURODIET (2000) 2g alpha-linolenic acid 200mg
  very long chain fatty acids per day
• British Nutrition Foundation (1992) 1 of energy
  from ALA
• Scientific Review Committee (Canada 1990)
  1,2-1,6 g/day n-3 fatty acids)
• In practise 1 energy procent (1 E) corresponds
  to 2-3g alpha-linolenic acid per day, depending
  on energy need

27
Intake of alpha-linolenic acid is usually lower
than recommended
Ref. Hulshof KF, van Erp-Baar MA, Anttolainen M,
et al. Intake of fatty acids in Western Europe
with emphasis on trans fatty acids the TRANSFAIR
Study. Eur J Clin Nutr. 1999 53(2)
143-157 Sanders TAB. Polyunsaturated fatty acids
in the food chain in Europe. Am J Clin Nutr.
2000 71(suppl)176S-8S
28
Omega-3 ja omega-6 fatty acids in different oils
29
Fatty acid composition of Camelina oil

• Camelina oil has an beneficial fatty acid
  composition
• Camelina oil is a good source of omega-3 fatty
  acids with perfect ratio of omega-6 and omega-3
  fatty acids
• (2,6 1)
• ? An effective way to increase the omega-3 fatty
  acids to the diet
• Camelina oil has a mild taste

Monityydytty-mättömät
Polyunsaturated fatty acids
30
Vegetable based omega-3 compared to marine based
omega-3

• CAMELINA
• Contains a-linolenic acid (ALA) which is
  metabolized in the body to active components
• Dose 1 E (2-3g a-linolenic acid) per day
• No risk for overdosing
• Neutral taste
• ? Safe, natural and vegetable based sorce of
  omega-3 fatty acids
• Dose Adequate Intake (AI) Nordic nutrition
  recommendations 2004, WHO 2003, Eurodiet 2000,
  NIH (National Institutes of Health) 1999

• FISH OIL
• Contains active EPA (eicosapentaenoic acid) and
  DHA (docosahexaenoic acid)
• Dose No recommendation (not considered
  essential)
• Recommended not to use more than 3g / day
• Negative effect of higher doses
• oxidation also in the body
• prevents blood clotting (bleeding time ?)
• raises LDL-cholesterol
• Taste (not convienient for food industry
  applications ? oxidation)

31
Safety of omega-3 fatty acids

• Alpha-linolenic acid (ALA)
• No recommendation for the upper safe intake (Note
  energy)
• Fish oils (EPA, DHA)
• The FDA (Food and Drug Administration) has ruled
  that intakes of up to 3g/day of marine omega-3
  fatty acids are GRAS (Generally Recognized As
  Safe)
• If the intake is more than 3g/day
• LDL-cholesterol ?
• Clinical bleeding ?
• Gastrointestinal upset
• Worsening glycemia in patients with impaired
  glucose tolerance and diabetes
• Consumption of a wide variety of fish species is
  the best approach to minimizing mercury exposure
  (Note children, pregnant and lactating women)
• Methylmercury
• Polychlorinated biphenyls (PCB)
• Dioxins
• Ref. Kris-Etherton, PM, Harris WS, Appel LJ.
  Fish consumption, fish oil, omega-3 fatty acids,
  and cardiovascular disease. Arterioscler Thromb
  Vasc Biol. 2003 23e20-e31

32
Benecol spread with Camelina

• BENECOL (with added Camelina-oil)
• 100g margarin contains
• 32g fat
• 7,2g stanol
• 4g omega-3 fatty acids
• Daily portion (30g) provides
• 9,6g fat (energy orange)
• 2g stanol
• 1,2g omega-3 fatty acids

• Example product
• 100g margarin contains
• 35g fat
• 7,5g sterols
• 1,3g omega-3 fatty acids
• Daily portion (30g) provides
• 10,5g fat
• 2g sterols
• 0,3g omega-3 fatty acids

33
Omega-3 nutrition claims

• High in omega-3
• Min. 0,6g ALA/100g or
• Min. 60mg EPA/DHA/100g
• As long as min. 30 of the dietary recommendation
  is met per average daily intake of product
• Source in omega-3
• Min. 0,3g ALA/100g or
• Min. 30mg EPA/DHA/100g
• As long as min. 15 of the dietary recommendation
  is met per average daily intake of the product

34
Omega-3 fatty acids are good for you

• Omega-3 fatty acids are essential fatty acids
• Omega-3 fatty acids improve heart health
• Most of us do not reach the recommended intake of
  omega-3 fatty acids