Title: A Collaboratory for IMRT treatment planning research
1A Collaboratory for IMRT treatment planning
research
- J Deasy1, E Lee2, M Langer3, T Bortfeld4, Y
Zhang5, H Liu6, R Mohan6, R Ahuja7, J Dempsey7, A
Pollack8, J Rosenman9, A Eisbruch10, R Rardin11,
J Purdy1, K Zakarian1, J Alaly1 - (1) Washington Univ, Saint Louis, MO, (2) Georgia
Inst Tech and Emory Univ, Atlanta, GA, (3)
Indiana Univ, Indianapolis, IN, (4) Massachusetts
General Hospital, Boston, MA, (5) Rice
University, Houston, TX, (6) UT M.D. Anderson
Cancer Center, Houston, TX, (7) University of
Florida, Gainesville, FL, (8) Fox Chase Cancer
Center, Philadelphia, PA, (9) Univ of North
Carolina, Chapel Hill, NC, (10) Univ Michigan,
Ann Arbor, MI, (11) Purdue Univ, W. Lafayette,
IN,
2Acknowledgements
- NCI grants CA 85181, and CA 90445 (PI JOD)
- NSF Grant DMI 0331755 (PI Eva Lee)
- NCI support through the ATC grant (PI J Purdy)
- A grant from Computerized Medical Systems, Inc.
- Jim Deye of NCI
3Motivation I
- Many IMRT treatment planning algorithms, but
- Few comparisons
- Tools for comparison and common data access are
missing - Common datasets are missing
- Few (no?) comparisons of techniques.
4Motivation II
- Many optimization experts are not in the field of
radiotherapy, e.g., in operations research
groups. - No access to radiotherapy datasets
- Little interaction with the field of radiotherapy
5Approach
- Construct common collaboratory framework
graphical and analytical plan review tools. - Provide a common approach to generating test
beamlet dosimetry data. - Compile common benchmark suite of anonymized
patient plans - and IMRT prescription challenges.
- All publicly available and open-source.
6Components
- CERR for plan review and analysis (common data
format) - Extensions to CERR to produce common beamlet
dosimetry (ORART Toolbox) - Treatment planning data exported in RTOG or DICOM
format, converted to CERR format
7CERR A Computational Environment for
Radiotherapy Research
- Matlab-based
- Cross-platform
- RTOG format-based
- Self-describing format
- Open-source
- Freely available via webpage http//deasylab.info,
or http//radium.wustl.edu/cerr
8Successful imports from
- CMS Focus (RTOG)
- Pinnacle (RTOG)
- TMS Helax (RTOG)
- Helios (DICOM)
- And others used for DICOM Connectathon
- No failuresso far
9CERR current major components
- Version 2.5 beta
- Transverse, coronal, sagittal slice viewers
- DVH calculation and display
- DICOM-RT Toolbox (Spezi)
- Contouring/re-contouring tools
- Plan metric comparison tools
- IMRT beamlet calculations
10CERR version 2.5 beta (latest released version)
11Recomputed DVHs generally the same to within RMSE
of 1
(Zakarian et al., 2003 AAPM mtg)
12MDACC dataset 1 (Liu)
13FLA dataset 1 (Dempsey)
14Wash-U Varian Dicom ex
15Providing beamlet data
- Operations researchers typically start with a
matrix description of the problem. - In our case
- Much, much faster than iteratively recomputing
dose
influence matrix
16IMRT beamlet generation the ORART toolbox
- Software routines giving Matlab/CERR users access
to beamlet dosimetry. - Based on written CWG specification.
- Integrated with CERR.
- Generation of beamlet data
- Dosimetry data access within Matlab
- Multiple output formats (binary and ASCII-based).
Easy to modify output formats
17ORART Toolbox beamlet dosimetry GUI setup
Computation time, typically a few minutes on PCs
18Access to beamlet data in Matlab
19Plan by Eva Lee based on toolbox beamlet data
20What will I be able to do with it?
- Import DICOM or RTOG datasets into Matlab
- Use on any PC or Unix workstation with Matlab
- Choose beams, generate beamlet matrices
- Recompute optimized dose
- Put back into CERR
- Compare with other researchers results
21The ORART benchmark paradigm
(third-party)
22Current issues
- Lack of built-in leaf sequencing. (To be added.)
- Lack of ability to re-export CT and contour data
into commercial treatment planning system. (To be
added.) - Dosimetric accuracy (MC integration complete I.
Kawrakow).
23Ongoing
- Collection of patient datasets (the ORART
benchmark) - HN (U Mich)
- Lung (WUSTL and NC)
- Prostate (FCCC, R. Price)
- Group testing of tools
- Refinements of tools and I/O capabilities