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Complications in Pregnancy


Gallbladder Dilated. Common GI Changes in Pregnancy ... Increased tendency for gallbladder dysfunction with possible need for surgery, ... – PowerPoint PPT presentation

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Title: Complications in Pregnancy

Complications in Pregnancy
  • Objectives for learning
  • Review some of the physiological changes in
  • Review case presentations for some medical and
    surgical conditions that occur during pregnancy

Physiological Adaptations to Pregnancy
  • Numerous normal changes in response to pregnancy
  • It is important to have an awareness of what is
    considered normal in pregnancy
  • Such awareness allows an obstetrician to diagnose
    and manage common problems such as
  • Hypertension
  • Hyperthyroidism
  • Anemia
  • Asthma
  • Diabetes
  • Seizure disorders
  • Urinary Tract Infections/ Acute Pyelonephritis

Weight Gain in Pregnancy
  • Normal weight gain can be 30-35 lbs in average
    patient and 50-70 lbs. in twin pregnancy
  • Daily requirements of 2000-2500 calories
  • Associated with good outcome, ie delivery of
    normal sized baby
  • Excess weight gain associated with variety of
  • GDM, pre-eclampsia, macrosomia
  • Total pregnancy expenditure is 75,000kcalories
  • Recommendations for appropriate weight gain in
    pregnancy based on initial weight, BMI

Weight Gain in Pregnancy
Gastrointestinal Changes
  • Key Changes
  • Appetite Usually increased, with
  • Gastric Reflux Sphincter relaxation
  • GI Motility Decreased
  • GI Transit Time Slower
  • Liver Functionally unchanged
  • Gallbladder Dilated

Common GI Changes in Pregnancy
  • Nausea and vomiting of pregnancy or morning
  • Exact etiology is unknown
  • Supportive therapy usually helpful
  • On rare occasion, TPN and hyperalimentation
  • Dietary cravings commonplace
  • Pica
  • Ptyalism
  • Increased tendency for gallbladder dysfunction
    with possible need for surgery, or laporoscopic

Hepatic Function Laboratory Studies
Hematological Changes in Pregnancy
  • Plasma volume increases early in pregnancy with a
    50 increase (and higher in higher order multiple
    pregnancies) and a delayed increase in RBC mass
    and volume but less than the plasma volume
  • Normal pregnancy associated with a demand of
    1000 milligrams of additional iron
  • 500 mg. to increase maternal RBC volume
  • 300 mg. tranpsorted to fetus
  • 200 mg. for normal iron loss
  • 60 mg. of elemental iron required daily, provided
    in 300 mg. of ferrous sulfate
  • Serum iron decreased
  • Transferrin and TIBC are increased

Iron Metabolism in Pregnancy
More Hematological Changes Occurring During
  • Pregnancy considered a hypercoagulable state
  • Fibrinogen increases to 450-600 mg/dl
  • Factors VII, VIII, IX and X increase
  • Prothrombin, Factor V, and XII are unchanged
  • Bleeding time does not change
  • Platelet count may increase to 450,000 to 600,000
  • WBC count may increase to as high as 20,000 due
    to an increase in granulocytes

Pulmonary Adaptations
  • Anatomical
  • Increased chest diameter, subcostal angle
    changes, increased diaphragmatic excursion with
    diaphragm elevated as well
  • Physiological
  • Hyperventilation, Increased IC,VC and Minute
    Volume, Residual volume decreased, Expiratory
    Reserve Volume decreased, Tidal volume increased
    by 40, pO2 increased, pCO2 decreased, arterial
    pH unchanged, and serum bicarbonate reduced

Pulmonary Changes in Pregnancy
Respiratory Changes in Pregnancy
Cardiac Changes in Pregnancy
  • Cardiac output increases around 50 from an
    increase in HR and SV (3L/min to 6.2L/min)
  • There is an additional 40 increase above that
    level during active labor
  • Immediately following delivery, cardiac output
    may be increased by an additional 10-20
  • Cardiac exam is different during pregnancy
  • Many patients will have an S3 after midpregnancy
  • Diastolic murmurs are usually considered serious
  • Systolic murmurs (flow murmurs) common
  • Displacment of heart is to right and upwards
  • EKG shows left axis deviation and low voltage QRS

Key Cardiovascular Changes During Pregnancy
Circulatory Changes in Pregnancy
Hemodynamic Changes During Labor
More Hemodynamic Changes
Renal Changes in Pregnancy
  • Minimal renal enlargement, bilaterally
  • Both renal pelvises and ureters are dilated
    (hydronephrosis of pregnancy)
  • Greater urinary stasis, ureteral compression,
    leading to urinary stasis and possilbe urinary
    tract infections, pyelonephritis
  • Loss of urinary control
  • Bladder capacity diminished
  • RPF increases to 75 of non-pregnant value

More Renal Changes in Pregnancy
  • GFR increases 50 over non-pregnant state
  • Creatinine clearance increases to 150-200 ml/min
  • Plasma osmolality decreases
  • Urine output is unchanged
  • There is an increased sensitivity to renin and
  • Renal glycosuria common
  • Proteinuria up to 300 mg/24 hours normal

Endocrine Changes with Pregnancy
  • Carbohydrate Metabolism
  • Overall effect is that pregnancy is diabetogenic
  • First half tendency to hypoglycemia
  • Second half tendency to hyperglycemia
  • Progressive insulin resistance as pregnancy
  • Progesterone
  • Estrogen
  • HPL
  • Typical FBS less than in non-pregnant state
  • Blunting response to meals, eating as pregnancy
  • Hypertrophy of beta cells as well

Diurnal Glucose and Insulin Changes in Late
Endocrine Changes in Pregnancy
  • Thyroid Function in Pregnancy
  • The normal pregnant woman remains euthyroid while
    pregnant despite/ with hormonal changes which
  • Estrogen production increases
  • Increased TBG
  • Increased total thyroxine, and T3
  • Free T4 and T3 remain unchanged
  • BMR increases 15-20 above normal
  • There is lowered T3 uptake during pregnancy
  • TSH does not cross the placenta

Thyroid Changes in Pregnancy, Both Mother and
Gestational Diabetes
  • A patient has a abnormal 1 hour glucola value of
    165mg at 28 weeks. Her 3 hour test is also
    abnormal and she is labeled as having gestational
  • Can you outline how she should be managed?
  • What is she at risk for when in labor?
  • What problems may happen in this infant?
  • What implications does this diagnosis have?

Diabetes and Pregnancy
  • A 22 year old female with type I Diabetes poorly
    controlled presents at 10 weeks for pregnancy
  • Can you outline her pregnancy risks?
  • What are the potential fetal complications?
  • What labs or other evaluations would you order?

Hypertension and Pregnancy
  • A 28 year old female with known chronic
    hypertension presents as a NOB and has a BP of
  • What laboratory studies are indicated?
  • Which antihypertensive agents can be used during
    pregnancy? Are any contraindicated?
  • Potential pregnancy complications?
  • Can you outline a management plan?

Viral Illnesses in Pregnancy
  • A patient calls and tells you she has been
    exposed to chicken pox at 10 weeks gestation.
  • How would you treat this patient?
  • What is she were 34 weeks pregnant?
  • What if the patient was rubella non-immune and
    she had exposure to that virus instead?
  • How do you counsel patients about the flu

GI Problems in Pregnancy
  • A new OB patient at 8 weeks gestation has
    severe nausea and vomitting with weight loss of
    10 lbs.
  • What is the likely diagnosis?
  • Associations?
  • Workup/treatment?
  • A patient complains of severe RUQ pain after
    eating and is diagnosed with acute cholecystitis.
  • How is this treated medically?
  • Are there any issues related to surgery?

Anemias in Pregnancy
  • A 27 year old female is found to be anemic on
    initial NOB testing with a hemoglobin of 9 grams.
  • What is the most common anemia in pregnancy?
  • How is the diagnosis made?
  • Treatment?
  • What are the recommendations for doing hemoglobin
    electrophoresis in pregnancy?
  • Management plan?

Renal Problems in Pregnancy
  • A patient is diagnosed with pyelonephritis in the
    first trimester.
  • What are the signs and symptoms?
  • Treatment?
  • What if she has recurrent symptoms?
  • How might she present in the third trimester?
  • Differential diagnosis?
  • Potential complications?

Thyroid Disease in Pregnancy
  • A woman has a goiter, is hyperthyroid and is 12
    weeks pregnant.
  • What are the signs and symptoms, physical
    findings, and lab results you would have for her?
  • How would you treat her during pregnancy?
  • Monitor her?
  • Infant issues?
  • If she were not pregnant, would your treatment be

Infectious Diseases and Pregnancy
  • A NOB has a test positive for chlamydia.
  • Treatment?
  • Other studies?
  • What are the recommendations for managing a HIV
    patient during pregnancy (labs) and at the time
    of delivery (method of delivery)?
  • What do you do if she refuses HIV testing?
  • Do you know how the infant is treated?

DVT/Pulmonary Emboli in Pregnancy
  • A patient has a history of a DVT in a previous
    pregnancy, now she is 10 weeks pregnant.
  • What are potential risk factors for this? Lab
  • How would you treat?
  • If this patient had cardiorespiratory arrest in
    labor, what would also be your on differential
  • What are the factors that contribute to DVTs and
    PEs occurring in pregnancy?
  • When are the most likely to occur?

Seizure Disorders in Pregnancy
  • A patient has a tonic-clonic seizure at 10 weeks
  • What is the most likely diagnosis? Others?
  • How do you treat a patient with seizures?
  • Any medications contraindicated?
  • If the patient is 37 weeks gestation and has a
    tonic-clonic seizure, what is the most likely
    diagnosis and management? What are other

Surgical Problems in Pregnancy
  • A normal OB at 8 weeks complains of RLQ pain?
  • What is your differential diagnosis?
  • If it is not an ectopic pregnancy or ovarian
    cyst, how would you treat this?
  • If this is an ovarian mass, when/why would you
    recommend surgery?
  • If this problem occurred at gt28 weeks, what might
    be on the differential diagnosis?

Drug Problems in Pregnancy
  • A 26 year old pregnant patient presents to the
    ER, with cramping, bleeding and is combative.
  • What is a likely diagnosis and how would you
    manage this patient?
  • What other tests would you order/do?
  • A NOB tells you that she has a history of alcohol
    abuse and is now pregnant.
  • How can you screen for alcoholism in pregnancy?
  • If she had binged at the start what would you
  • What are the stigma of fetal alcohol syndrome?

Pulmonary Problems in Pregnancy
  • A 30 year old woman is pregnant and is a severe
  • What historical factors would you ask?
  • What is the best way to evaluate her status?
  • What are the recs for any of the agents for
    treatment in pregnancy?
  • A RN now pregnant wants to be tested for TB.
  • Your recommendations?
  • A undelivered severe pre-eclamptic has pulmonary
  • What is your treatment?

Depression and Pregnancy
  • A patient presents as a NOB and has a history of
    depression, currently on no therapy
  • How can she be screened during pregnancy?
  • What are your recommendations for treatment?
  • Risk factors for depression in pregnancy?
  • How do you counsel about the post partum blues
    vs. depression?
  • How common is Post Partum Depression?

Cardiac Problems in Pregnancy
  • A patient presents with several questions
    concerning such issues
  • What murmurs are normal in pregnancy?
  • Is it safe to become pregnant if there is a
    small VSD or ASD, repaired? A PDA closure?
  • How about if there is MR? Mitral Stenosis?
  • What if there is a corrected Tetrology of Fallot?
  • If a patient had a peripartum cardiomyopathy, at
    what time should her cardiac function be
    evaluated to provide prognosis?