Principles of Immunology Transplantation Immunology 42506 - PowerPoint PPT Presentation

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Principles of Immunology Transplantation Immunology 42506

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C mediated Ab response. ADCC. CTLs. DTH. Compatibility Tests. ABO. Microcytotoxicity. Pre existing Ab. C mediated. Mixed lymphocyte reaction ... – PowerPoint PPT presentation

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Title: Principles of Immunology Transplantation Immunology 42506


1
Principles of Immunology Transplantation
Immunology 4/25/06
2
Word/Terms List
  • Allograft
  • Autograft
  • GVH
  • HLA
  • Isograft
  • MHC
  • Xenograft

3
Transplantation Immunology
  • Types of transplants
  • Autograft
  • Isograft
  • Allograft
  • Xenograft

4
Graft Rejection
  • First set
  • Second set
  • Analogous to primary and secondary antibody
    response

5
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7
Causes of Rejection
  • MHC HLA antigens in humans
  • Haplotypes
  • DTH reaction
  • Cell-mediated immunity

8
Stages of Rejection
  • Sensitization-
  • APCs from donor
  • APCs from host
  • Passenger leukocytes
  • CD8 and CD4 both react

9
Stages of Rejection
  • Effector stage
  • C mediated Ab response
  • ADCC
  • CTLs
  • DTH

10
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11
Compatibility Tests
  • ABO
  • Microcytotoxicity
  • Pre existing Ab
  • C mediated
  • Mixed lymphocyte reaction
  • Measures T helper activation
  • Uses radioactive thymidine as determinant

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15
Clinical Types of Rejection
  • Hyperacute
  • lt24 hours
  • Preexisting Ab
  • ABO mismatch
  • Acute
  • Weeks
  • Macrophages
  • Cytokines
  • Chronic
  • Months or longer
  • Humoral and cell-mediated

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17
General Immunosupression
  • Mitotic Inhibitors
  • Affects all rapidly dividing cells
  • Steroids
  • Anti inflammatory
  • Cytokine inhibitors
  • Inhibits T cell proliferation

18
Specific Immunosupression
  • Monoclonal Ab
  • Anti CD3
  • Blocking co stimulation
  • CTLA injection

19
Immune Tolerance
  • Non immunogenic tissue
  • Privileged sites
  • Induced tolerance
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